Excerpts

Two-way RM ANOVA revealed a highly significant time factor ( p = 0.0043) and significant patient variance ( p = 0.0180).

Among the mutations analyzed, KRAS was the only one associated with a diagnostic predictive power for BCL2L15 , as the chi-squared test was highly significant ( p = 0.0043), with 79% of BCL2L15 -high expressing subjects in the MUT subgroup ( Figure 6 J).

8 a) showed a highly significant elongation of ANF dendrites re control at 1 week post exposure (p = 0.0043, 2-way ANOVA; p = 0.036 @16 kHz, Holm-Sidak multiple comparisons), with a return to normal at 1 month (p = 0.189 2-way ANOVA; p = 0.735 @ 16 kHz, Holm-Sidak multiple comparisons).

Thereby, the differences between the elevations of the age-groups 17–33 years and 49–70 years were highly significant (F = 10.48, DFn = 1, DFd = 19, P = 0.0043, Fig 6 ).

No such effect was observed across comparison arms, leading to a nominally significant single nucleotide polymorphism×treatment interaction ( P = 4.3 × 10 −3 ).

The difference was highly significant ( P = 0.0043, Wilcoxon rank-sum test) ( Fig. 7 B) and the half-time of all silenced genes fell in the silenced category (<0.9 d) ( Fig. 1 G), and three of five not silenced genes also fell in the respective category (>1.6 d) ( Fig. 1 G).

Statistical analysis confirmed these differences as highly significant (p < 0.0043 for quartz; p = 0.0074 for glass, both parametric and non-parametric tests).

Although our data, in general, did not reach statistical significance, it can be deduced that high BRK expression was significantly associated with poor RFS in tamoxifen-treatment patients ( n = 161; P = 0.0043; Additional file 2 : Figure S3G), thus strengthening the rationale for ER/BRK co-targeting in ER-positive breast cancers.

RESULTS: On comparison between the male and female participants using stress and anxiety-related variables, 43.81% of males as against 56.19% of the female participants reported that they felt horrified due to the pandemic with the results being statistically highly significant ( P = 0.0043).

Correlation coefficients among the different personality traits were, again except for the trait constitution, likewise highly significant (P<0.0043) and ranged between 0.44 (temperament – willingness-to-work) and 0.85 (overall personality – character).

Consistent with the mRNA trends, the protein expression level of EphA2 also showed an increasing trend in ectopic endometrium ( p =0.0043, Figure 2B ).

The difference between PHENO/MMS and CONTROL is highly significant (Wilcoxon p-value<0.0043).

This showed that the distribution into the three categories separately was highly significant ( P =0.0043) and there were also significantly more patients with G2+G3 vs G1 in the TNF−859T polymorphism group ( P =0.023).

Portal vein flow velocity decreased in the NLS group (27 cm/s before KPE to 23 cm/s 3 months after KPE, p < 0.001), but remained unchanged in the KPE failure group. Portal vein flow velocity before KPE compared with 6-month NLS The logistic regression analysis of each patient's portal vein flow velocity before KPE reveals a highly significant difference ( p < 0.0043) and a predictive value for NLS at 6 months post-KPE of AUC = 0.8371 (Fig. 2 panel D1).

Comparison between the groups treated with active or inactive DI virus showed a highly significant statistical difference in the severity of disease (p = 0.0043) with a one tailed Mann-Whitney U test.

This potential effect was highly significant in both validation cohorts (JAAMSR, P = 0.0043, adjusted hazard ratio 0.51, 95% CI 0.32–0.81; SPH, P = 0.018, adjusted hazard ratio 0.76, 95% CI 0.61–0.95) (Additional file 4 : Figure S3b-c).

It is noteworthy that the trend for the number of implants was of borderline significance (S-score = 8, Sens slope estimate 8.44, Mann-Kendall statistic = 1.959, P = 0.0500) and for the number of detox's was highly significant (S-score = 19, Sens slope estimate = 14.56, Mann-Kendall statistic 2.853, P = 0.0043) as illustrated for both variables in Figure 4 .

Regarding the other shared genes, the functional enrichment analysis (via TopGO) using CDC42BPB (CDC42 binding protein kinase beta, with a predominant role in regulating actin cytoskeleton and cellular polarity [ 27 ]), SLC1A5 (Solute Carrier Family 1 Member 5, in charge of carrying neutral amino acids through the cellular membrane [ 28 ]), and SLC22A18AS (Solute Carrier Family 22 Member 18 Antisense, encodes a long non-coding RNA, involved in epigenetic regulation of the gene SLC22A18) revealed highly significant biological processes (adjusted p = 0.0043, fold enrichment = 100), including: L-glutamine import across the plasma membrane (GO:1903803), positive regulation of the vitamin D receptor signaling pathway (GO:0070564), L-aspartate import across the plasma membrane (GO:0140409), L-serine transport (GO:0015825), and glutamine transport (GO:0006868).

The results indicated that the second model was well-suited for the prediction of experimental data, supported by a highly significant model F value of 8.92 and a low p value of p = 0.0043.

Random Forest showed highly significant differences (χ2 = 8.12, p = 0.0044), with CATBoost achieving 7 fewer misclassifications on 2,000 test samples.

After normalizing for the difference in sequence context between the datatypes, we found a difference in the proportion of a 5′ CCG 3′ → 5′CTG 3′ mutational signature that was nominally significant in our South Asian ancestry study compared to those from the European studies (ratio 1.35, p = 0.0044) (Fig. 3b ).

From the regression analysis of PBD in Table 3 , the fitting model for PCPS production was highly significant ( p = 0.0044).

For cooperation streaks, 16 Hz Sync significantly differed from the control ( P = 2 × 10 −3 , corrected), while 16 Hz Rand failed to reach significance ( P = 4.4 × 10 −3 , corrected).

Regarding the 1000 Genomes Project global subjects, the SDS-identified top SNPs in ADH clusters and BRAP-ALDH2 showed nominally significant excess of DAF heterogeneity ( P < 0.0044 for DAF heterogeneity enrichment test; Table 1 and Fig. 4a ).

Association with Clinicopathological Parameters EGFR , FLT4 and FIGF show highly significant differences in their expression levels between the four investigated tumor entities (p=0.0044, p=0.0054 and p=0.0096, respectively).