Excerpts

Following corrections, PCT remained a highly significant predictor for secondary bacterial infection, positive blood (OR = 1.62, CI [1.15, 2.28], p = 5.8E-03) and sputum cultures (OR = 1.44, CI [1.10–1.89], p = 8.7E-03), as well as for ventilation (OR = 1.47, CI [1.22–1.77], p = 0.000039), death (OR = 1.39, CI [1.15–1.69], p = 0.00077), and ICU admission (OR = 1.48 CI [1.23–1.78], p = 0.000036) by day 28.

A one-sided K-S test shows a highly significant reduction in tumor burden in the miRNA-treated mice compared to the water-treated mice ( P = 0.0058).

The peak voxel of this cluster showed a trend towards significance using the pre-established corrected threshold (x = –33, y = –24, z = -14, T = 5.64, p = 0.0058, FWE-corrected).

No relationships were evident for irritability, tension (this approached significance, p = .0058), salivation, or the two affectively positive factors (positive anticipation, positive mood). 3.4.

We found nominally significant subcortical volumetric differences in the bilateral thalami (left Cohen d = −0.29, p = 5.83 × 10 −3 ; right d = −0.24, p = 0.025), bilateral hippocampi (left d = −0.36, p = 8.85 × 10 −4 ; right d = −0.41, p = 1.15 × 10 −4 ), bilateral amygdalae (left d = −0.31, p = 4.02 × 10 −3 ; right d = −0.17, p = 0.014) and right nucleus accumbens ( d = −0.21, p = 0.048) between the patients with schizophrenia and controls ( Figure 2A and Figure 3 ).

4 C) and remained so over 240 min with significant reductions at 120 and 180 min and a trend toward significance at 90 and 240 min ( p = 0.00585, 0.0260, 0.0787 and 0.0787, respectively).

ii) Nominally significant differences were observed in the levels of IL-1RA (p = 0.0059), YKL40 (p = 0.0069), CatS (p = 0.013), sTNFR1 (p = 0.031), and BDNF (p = 0.020), where these factors exhibited higher plasma levels in Cannabis user SCZ patients than in non-users. iii) These differences in systemic levels were not reflected by altered mRNA expression of genes encoding sgp130, IL-1RA, YKL40, CatS, sTNFR1, and BDNF in whole blood.

As shown in Figure 1 C, pre-miR-221 co-transfections resulted in a highly significant reduction of relative Luciferase activity (39.97 ± 4.88 RLU, p = 0.0059) compared to control co-transfections (81.35 ± 13.8 RLU).

In contrast, the PMCA1b mRNA showed a trend to increase with age in jejunum ( P = 0.0059) and ileum ( P = 0.0825) whereas there was a decrease for PMCA1b protein in 12-18 wk ( P ≤ 0.0009).

Overall, a positive trend was observed over time for moderate to severe anxiety and depression, p = 0.0059 and 0.0762, respectively.

The intra-laboratory %CVs presented a decreasing trend with increasing insulin concentration (ANOVA: P =0.0059; 202111 vs. 202113 P =0.0255; 202111 vs. 202115 P =0.0063); however, no distinct trend was observed for C-peptide (ANOVA: P =0.702) ( Fig. 1 ).

An interaction indicative of relatively lower activity during mental illness trait self-evaluation in schizophrenia was of borderline significance ( p < 0.0059) in one area: right inferior parietal lobule (BA40); peak Talairach coordinates, 47, -33, 37 (see Figure 3 ).

The time between U gait and U crit – hereafter classified as ‘time spent bursting’ (TSB) – revealed a decreasing trend with temperature ( P =0.0059), with no apparent P CO 2 effect ( P =0.8760).

The analysis revealed a moderately significant difference between the two blood sources in one direction ( P = 0.0059); parasitaemia levels were slightly higher in capillary blood than venous blood.

Time matching within reciprocated grooming bouts Analyses of all reciprocated grooming bouts suggested that the relationship between the amount of time each initiator spent grooming the recipient and the amount of time the receiver reciprocated was extremely significant (weighted least-squares regression analysis, F 1,102 = 7.91, p = 0.0059).

Permutation tests confirmed that the differences between attention-derived residues and random selection were highly significant for the top 1–12% thresholds ( p = 0.000999), moderately significant at 13% ( p = 0.00599) and 14% ( p = 0.01798), but became statistically insignificant beyond the 15% threshold ( p > 0.05).

A few other associations were borderline significant: rs7117858 ( r -value = 0.054, AA P-value = 0.006) and rs7108738 ( r -value = 0.059, AA P-value = 0.004), both near LUZP2 ; and rs12272917 ( r -value = 0.092, AA P-value = 0.01) in PPP6R3 .

The channel pair Fz−C5 showed the highest test-statistic value across the two nights, which approached significance after correction (Night 1: F-value = 8.2, uncorrected p = 0.006, corrected p = 0.082, Cohen’s d = −0.89; Night 2: F-value = 7.9, uncorrected p = 0.007, corrected p = 0.098, Cohen’s d = −0.87). 3.2.2 Results for fast spindles Panels C and D in Fig. 2 show the topographical distributions of the PLV and the MPD, respectively, between the parietal seed channel Pz and all other channels for fast spindles.

These findings are consistent with those reported by Mersch et al., who observed a significant trend indicating an increased incidence of cervical cancer in BRCA2 carriers relative to the general population (p = 0.006) 22 .

Whether administered at 0, 6 or 9 h, AIG increased survival and overall had a highly significant survival effect ( p = 0.006) ( Figure 6 ).

Subsequent application of NH 4 Cl solution resulted in a rapid depolarization of all bTRPV3 oocytes studied (− 4.0 ± 2.2 mV, p = 0.008) with a highly significant pH i decline to 6.22 ± 0.18 ( p = 0.006).

Similarly, the core spliceosome element Sf3b1 did not show any alterations in brain expression levels either during developmental phases or during ageing, with the exception of a single nominally significant reduction in expression of Sf3b1 in the 13–15-year-old group (beta coefficient: − 0.275; p = 0.006; Supplementary table S6 ).

Fig S1 ), and excluding a single outlying observation (#13) from the NP group with paradoxical large increase in both SUV values and LAT1 relevant AMAs, the negative associations of SUV with LAT1 relevant AMAs were highly significant for both SUVB (− 0.082 per 100 μM, p = 0.006), SUVT mean (− 0.132 per 100 μM, p0.005) and SUVT max (− 0.159 per 100 μM, p = 0.020).

Between-group treatment differences were nominally significant for UPDRS Part II ( p = 0.006) and CGI-C ( p < 0.001) at Week 26 in favor of LCIG; however, statistical significance could not be claimed in light of primary efficacy outcomes.

ACR showed highly significant association with the need for inotropes ( P =0.006) and Multiorgan dysfunction ( P = 0.004).