Barely Significant

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highly significantP = 0.0060.1× alphaqualifiedgold
Moreover, the interaction between self-reported history of neuropathy/nerve problems and glycemia arm continued to remain highly significant ( P = 0.006) after adjusting for age, sex, waist circumference, smoking, diabetes duration, hypoglycemic agents used, history of retinopathy, history of amputation, and systolic blood pressure.
highly significantP = 0.0060.1× alphaqualifiedgold
The increase was consistent across all three Hoxb regions tested (supplementary Table S2 ) and the difference in modification levels between the VPA-treated and untreated Hox genes was highly significant (H4K8ac, P = 0.006, H3K4me3, P = 0.0008; this and all subsequent comparisons use Student's two-tailed paired t test).
nominally significantp = 0.0060.1× alphagold
We observed several complex interactions, notably suggesting an increased risk of severe neutropenia in patients carrying a homozygous variant CYP3A5 rs776746 genotype (nominally significant OR 5.58, p = 0.006) and a potential pleiotropic protective effect from NFATC2 rs6021191 (OR 0.09, p = 0.001).
highly significantP=0.0060.1× alphaqualifiedgold
Second, stratifying the cohort by the clinical eGFR cut-off of 60 mL/min/1.73 m 2 revealed a clear moderating effect: the GMV reduction in the CI group was not significant in patients with eGFR ≥60 mL/min/1.73 m 2 (P=0.148) but was highly significant in those with eGFR <60 mL/min/1.73 m 2 (P=0.006; Table S3 ).
The absolute difference between QFR and FFR was greater in the RCA than in the Cx ( p = 0.038) and tended to be greater in the Cx than in the LAD, but this did not reach statistical significance, whereas it was smaller in female patients ( p = 0.006) and in patients with aortic stenosis ( p = 0.033), as shown in Figure 5 c.