Inspection of COVID-19 disease severity outcomes, including admission to intensive care, reveal nominally significant risk associations with A*11:01 (FET p = 0.0078) and C*04:01 (FET p = 0.0087).
Excerpts
When this outlier was no longer considered in the analysis, the ANOVA was highly significant ( p = 0.0078).
In summary, all spines that displayed significant morphological changes upon TEA treatment ( Fig 2A ) also displayed a highly significant increase in dynamics of the short as well as the long actin filaments, τ 1 and τ 2 ( Fig 2C and 2D , p = 0,0078 and 0,0008, respectively), and an increase in the calculated number of long filament, N 2 ( Fig 2F , p = 0,0014).
Comparison of vFh punctate brain activation in sedated (n = 6) and unsedated (n = 5) infants across all ROIs revealed a highly significant effect of sedation upon vFh punctate activation (two-way ANOVA, p = 0.0078).
When we quantified total metastatic burden using luciferase imaging, the differences between the vehicle and BGJ-398 treatment groups were highly significant ( Fig. 5B,C: p = 0.0078).
The correlation between predicted sex ratio and the sex ratio observed is highly significant ( r 2 = 0.931, p = 0.0078).
The mean of BDNF plasma levels had a decreasing trend by playing the scary video game (P=0.007813) ( Figure 4 ).
In addition, the Mann-Whitney test showed a highly significant difference (p-value = 0.00787, 2-sided) in the amount of Pf CSP in the unstained and stained groups.
Since LGD cases showed a much more predominant positive/negative ratio, the overall intergroup differences were highly significant (Fisher’s two-tailed test, p =0.0079).
Most subgroups benefited from nivolumab plus chemotherapy compared with chemotherapy alone, and the interim analysis showed a favorable trend for OS (HR = 0.57; p = 0.0079).
There was also a highly significant negative association of immunologic response among individuals who had baseline CD4+ cell counts between 350 and 500 (AHR = 0.285; 95% CI: 0.1128–0.719; p<0.0079).
The highly significant reduction in uACR in APP/PS1 mice compared to wild-type ( p = 0.0079) is consistent with glomerular microvascular dysfunction.
8 Further analysis revealed that memory T cells (CD45RO + ) were predominantly affected within the CD4 + and the CD8 + T cell population, resulting in a highly significant reduction in CD8 + as well as CD4 + memory T cells ( figure 1B ; 29.90%, p = 0.0079 and 31.13%, p = 0.0002, respectively).
A significant trend for loss of signal was observed in both females and males, p=0.0079 and p=0.0353 respectively.
By applying each risk score to the additional validation series of controls and JMML samples ( Online Supplementary Table S5 ) we confirmed highly significant differences in the discriminatory potential with both models ( P =0.0079 and P =0.0008; Figure 3C ).
The Lassa viral challenge seed used in our study was uniformly lethal in 12 of 12 cynomolgus monkeys challenged by the same route with a comparable dose [ 33 ] and three of three cynomolgus monkeys with the exact same dose (T.W.G., unpublished data); thus, protection of four of four VSVΔG/LVGPC-vaccinated monkeys is highly significant ( p = 0.0079).
We now show that there is a highly significant main effect of virus (n=5 P35 and 3 P115 mCherry cells and 7 P35 and 6 P115 hM4DG i -mCherry cells, 2way ANOVA, F (1,17) =9.069, p=0.0079) but no main effect of age (n=5 P35 and 3 P115 mCherry cells and 7 P35 and 6 P115 hM4D cells, 2-way ANOVA, F (1,17) =0.1391, p=0.7138) nor any interaction of age and virus (n=5 P35 and 3 P115 mCherry cells and 7 P35 and 6 P115 hM4D cells, 2-way ANOVA, F (1,17) =0.9260, p=0.3494).
Conversely, there is a clear trend towards increased glycolytic capacity associated with T cell CD69 expression, including in CD4 + naïve (3.38 versus 38.55%, P = .0079), CD4 + TCM (5.65 versus 37.50%, P = .0317), CD8 + naïve (3.80 versus 34.05%, P = .0159) and CD8 + TEM (10.83 versus 44.11%, P = .0317) populations ( Fig. 7D ).
3E ); this difference in outcomes was highly significant (p=0.0079; Fisher exact test).
In the brain-specific gene set, a highly significant positive correlation ( r = 0.992; P = 0.0079) was observed; that is, genes that are located in close proximity to more human-specific TF-binding sites manifest higher rates of protein evolution ( fig. 4 and supplementary fig.
ERBB2 ‐mutated tumors displayed a strong trend toward concurrent high TMB and high PD‐L1 expression (Fisher exact test, p = .0079; p adj = .056) (Figure 3 ).
But after one week of neuronal differentiation, we could show a highly significant (p = 0,0079) increase of nuclear NF-κB RELA in females only.
For peak 2, however, this effect only showed a strong trend towards significance (p = 0.0079), which failed to remain significant after Bonferroni correction.
Results In rats, analyzed MRI scans showed a significant trend of increase in the % gadolinium in brain tissues as a result of hyperbaric oxygen pressures ( p-value = 0.0079 ).
Highly significant correlations in gene expression were observed between qRT-PCR and RNA-seq ( R 2 = 0.5217 to 0.9479; p = 7.98E-3 to 9.66E-8; n = 12), indicating the RNA-seq data were reliable.