Excerpts

Abexinostat increases tumor growth delay when used in triple combination in a borderline significant way (p=0.05) with a clear trend to improved survival (logrank test for trend p= 0.0096) (Figure 6F , Supplementary Figure 2E ).

However, highly significant elevated CM AAb titers were found in our cohort of non-recovered patients (n=6) ( Figure 1B , p=0.0096) compared to normal healthy subjects.

There was a highly significant difference in the gender distribution between the two groups ( P = 0.0096).

The results showed a nominally significant positive causal relationship between COPD and daytime napping (OR = 1.010, 95% CI: 1.002-1.017; p = 0.0096).

Here, a highly significant positive influence of the N gene on the normalized variation rate was identified ( P = 0.0096, estimate: 0.876, standard error [SE]: 0.338), which means that this gene shows a significantly larger number of unique variants compared to the other regions of the SARS-CoV-2 genome.

Localization of HORMADs in pachytene spermatocytes Median HORMAD1/2 signal intensities on synapsed axes decrease slightly as cells progress from zygotene to pachytene ( Figures 5A, 5B ; Mann-Whitney U test, p = 0.08 (marginally significant) for HORMAD1 and p<0.0096 for HORMAD2), while the intensity of SYCP1 signal increases during this time ( Figures 5A, 5B ; p<0.0001).

The difference was determined to be highly significant by a Student t-test (p = 0.00966).

This increase in ED 50 was highly significant across five donors ( P = 0.0097) and was comparable to that seen previously for lymphostatin with a substitution of three alanine residues for a DTD motif in the glycosyltransferase domain (rLifA DTD-AAA ). 12 Our data indicate that the cysteine protease motif is required for the ability of lymphostatin to block mitogen-activated proliferation of bovine T cells, without obvious alteration of its secondary or tertiary structure.

Results Skull base meningioma treatment plans with IMRT: Dose to OAR For plans calculated for a total dose of 54 Gy, in 9 out of 10 patients PET-based target volumes lead to a reduction of brain stem D max which was highly significant at p = 0.0097.

In addition to the 11 significant female-biased pathways, we identified two male-biased pathways with borderline significance: pathways related to programmed cell death protein 1 (PD-1), programmed cell death-ligand1 (PD-L1) cancer immunotherapy (z-score = − 0.82, -log( p ) = 2.01) and p53 signaling (z-score = − 0.45, -log( p ) = 1.64).

This cluster also showed nominally significant enrichment for the two overlapping GO terms "fatty acid metabolic process" (GO:0006631, p = 9.8x10 -3 ) and "lipid metabolic process" (GO:0006629, p = 0.029), which include Abhd5 , Apoe , C3 , Ces1d , Echdc2 , Fabp4 , Fads3 , Gpam , Hsd11b1 , Liph , Lpin2 , Lpl , Pmvk , Ptgs2 , Scd1 , Sftpb , and Vldlr .

Subsequent non-parametric Steel’s multiple comparisons indicated that SP10 significantly increased the measured values relative to the control group ( p = 0.0098, 95% CI [0.80 to 5.70], Cliff’s delta = 1.0), whereas Roxadustat also showed an elevation with a trend toward significance ( p = 0.0098, 95% CI [0.80 to 3.60], Cliff’s delta = 1.0).

4J ), Scn2a +/+ and Scn2a +/− adult mice did not show any significant differences in the time spent immobile, although a tendency to decreased immobility time was observed for Scn2a +/− mice at the end of the 6-min session (two-way repeated measures ANOVA main, F(1, 26) = 3.15, p = 0.0875 for genotype (borderline significance); F(2, 52) = 5.06, p = 0.0098 for time; F(2, 52) = 0.72, p = 0.4892 for the interaction).

Cox models, estimated separately in grade I–II and grade III tumors, indicated a highly significant association between ECM3 and worse survival probability only in grade III tumors (HR = 3.0, 95% CI = 1.3–7.0, p = 0.0098).

Serotonin was positively associated with gut permeability but was of marginal significance (p = 0.0098, q = 0.050007).

We observed a highly significant increase in the absolute number and in the proportion of emergency admissions in 2020 (n = 79; 13%) relative to in 2019 (n = 50; 8%) ( p < 0.0098).

We observed 8 nominally significant associations in the replication cohort, more than would be expected under the null ( p = 0.0098 based on a binomial distribution with 5% chance of success).

Among the other loci with P < 1 × 10 −5 in the discovery set, one (rs10555080, aka rs72397229, on 19q12) showed a nominally significant association with DPN in the validation set ( P = 0.0098), resulting in a P value in the notable range ( P = 2.6 × 10 −7 ) in the two sets combined.

The incinerator was highly significant (p = 0.0098), with an excess relative risk of 6.7 and a very rapid decay moving away from the source.

Expression of the Traf2 gene was up-regulated in the model group, which was highly significant ( P = 0.00984), and DECB could promote the expression of this gene (the ratio of the DECB group/model group was 1.44). 5.

The first negative peak was found to be highly significant with p < 0.0099 and average cluster t-statistic = −101.32.

The difference observed for neuronal MSPs was highly significant and more pronounced than the difference observed for deltaCTEno2 ( p = 9.9 × 10 −3 vs. p = 0.028, Fig. 4 b).

fabae on CMV-infected compared with mock-inoculated plants were highly significant [Pairwise Peto-Peto: p = 0.0099 ( Figure 5B , Supporting Information: Excel File 3 )].

The number of forks was nearly double in basal cuttings compared to terminal cuttings, a difference that is highly significant ( p = 0.0099).

Concerning MNX1 , we report a moderate but highly significant “cross-over” interaction (10.9% of total variance, p = 0.0099) with a positive main effect of microwell width (79% of total variance, p < 0.0001), while the effect of depth (0.73% of total variance, p = 0.35) was not significant.