Barely Significant

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highly significantp < 0.00010.0× alphaqualifiedgold
However, when we transiently expressed a constitutively active form of Rab8a, using the same promoter (t aCP:mCherry-Rab8aCA ), we observed highly significant rescue of OS development in the mutant PRs expressing this transgene (Fig. 6D–D’ and red circles in E, p < 0.0001, Student’s t -test), with a majority of expressing PRs now displaying a nicely elongated OS.
highly significantp < 0.00010.0× alphaqualifiedgold
After 120 days of therapy, pitting edema score increased significantly in racemic amlodipine group compared to (S)-amlodipine ( p = 0.038) and increment of score was highly significant ( p < 0.0001) with amlodipine compared with baseline value (Table 2 ).
highly significantp < 0.00010.0× alphaqualifiedgold
Key Findings • The mean percent decrease from baseline in ulcer area over the treatment period was highly significant for both the collagenase ( p < 0.0001) and for the silver ( p < 0.0001) treatment groups. • Ulcers treated with clostridial collagenase had a 55% greater mean reduction in area from baseline when compared with the silver control group at the end of treatment ( p = 0.071). • Silver treatment provide
highly significantp < 0.00010.0× alphaqualifiedgold
Statistical analysis revealed that signal differences between Lipo‐21 and Lipo‐R were not significant at 10 0 particles/mL (noting that this nominal concentration does not literally correspond to a single vesicle per mL due to inherent variability in NTA‐based quantification), but became significant at 10 2 particles/mL ( ** p < 0.01) and highly significant at higher EV concentrations ( **** p < 0.0001).
highly significantp < 0.00010.0× alphaqualifiedgold
In the dentate gyrus (DG), a highly significant interaction was found (F(1,8) = 883.0, p < 0.0001), reflecting a differential upregulation where β-catenin increased more profoundly (mean difference = 53.31%, 95% CI [52.31%–54.31%], Cohen’s d = 106.2) than Wnt7a (mean difference = 38.03%, 95% CI [37.03%–39.03%], Cohen’s d = 99.9).
highly significantp -value < 0.00010.0× alphaqualifiedgold
After statistical analysis, the F -value of the APS of the lignin nanoparticles model is 230.57, all of which are highly significant ( p -value < 0.0001), and the p -value of the lack-of-fit term is not significant ( p > 0.05), suggesting that the model is accurate and reliable.
highly significantp < 0.00010.0× alphaqualifiedgold
Analysis of GMFI revealed parallel results, with highly significant MOI effects in MDA-MB-231 (F(2,6) = 427.7, p < 0.0001) and MDA-MB-468 (F(2,6) = 297.6, p < 0.0001), confirming robust dose-dependent increases in bacterial load, whereas MDA-MB-453 exhibited negligible changes.