Excerpts

However, a few motifs showed highly significant position-specific overrepresentation, with 106 6-mers exhibiting spatial bias at a significance level of P < 1 e –25.

Nevertheless, the highly significant genetic correlation ( p < 1 × 10 –25 ) implies that the genetic association between MetS and CAVS retains biological importance even within this low heritability context.

Furthermore, although enrichment of RNAs with mitochondrial functions among the Leotiomyceta Puf3 targets was highly significant ( Fig 4B , odds-ratio = 3.9, p = 10 −25 by Fisher's exact test), and the overlap with Saccharomycotina Puf3 targets was also significant (13%, odds-ratio = 3.2, p = 10 −6 by Fisher's exact test), the Leotiomyceta Puf3 target set included only 26 of the 202 Saccharomycotina Puf3 targets that have orthologs in N . crassa and included 87 mitochondrial targets not observed in Saccharomycotina.

Gene Ontology (GO) analysis of the upregulated genes by miR-182 deficiency during RANKL-induced osteoclastogenesis revealed highly significant activation of genes involved in defense response, in particular interferon-β response ( p < 10 −25 , Fig. 4b ).

Of note, a recent study reporting a highly significant genetic correlation between endometriosis and migraine (r g =0.38, p=2.30×10 -25 ) also implicated TRIM32 as an overlapping gene between the two disorders. 37 The role of TRIM32 as a potential risk variant in migraine, CTS, and endometriosis is yet unclear and requires further study, though it is intriguing to note its association with three disorders that predominantly affect females. 38 – 40 The notion of migraine as a peripheral nerve disorder remains debatable, as it conflicts with longstanding theories of central generation of migraine.

A z test was carried out and the differences between the population and expected means were highly significant, ranging from p = 2.34 × 10 −25 down to p < 1 × 10 −250 .

The association of rs4803217 with sustained virological response (defined as absence of detectable HCV RNA in serum at least 24 weeks after discontinuation of treatment) was extremely significant (p = 2.48 ×10 −25 ) in the European-American population ( Table 1 ).

All four features showed highly significant differences among classes (duration: H = 143.6, p ≈ 3.0 × 10 −25 ; mean F 0 : H = 220.9, p ≈ 3.4 × 10 −41 ; spectral centroid: H = 255.5, p ≈ 2.0 × 10 −48 ; RMS energy: H = 202.9, p ≈ 1.9 × 10 −37 ), confirming that temporal, spectral, and energy-based parameters all carry strong class-discriminative information.

hypo-methylated DMCs, we observed a highly significant difference in the distribution of hyper- vs. hypo-methylated DMRs with respect to CGIs (Supplementary Fig. 3A, p = 3.22 × 10 − 25 ) and RefSeq genes (Supplementary Fig. 3B, p = 3.22 × 10 − 25 ).

GWAS mapping also detected the QTL on chromosomes 12 (19.3 Mbp) as highly significant (p-value = 3.62E−25).

For the 100 top-ranked exposure-group differentially methylated positions, there was a highly significant negative correlation between exposure-group DNA methylation differences and effect sizes at the same probes for both IQ ( r =−0.82, P =4.48 × 10 −25 , Supplementary Figure 6 ) and ToM ( r =−0.89, P =2.23 × 10 −35 , Figure 3a ).

Omnibus results showed highly significant differences among groups (F > 11) for CSS ( P = 4.549e −25 ), MCS ( P = 6.361e −5 ), SAS ( P = 8.919e −8 ), and SDS ( P = 1.229e −8 ).

Association of FECD grade with TCF4 was highly significant (OR = 6.01 at rs613872; p = 4.8×10 −25 ), and remained significant when adjusted for changes in CCT (OR = 4.84; p = 2.2×10 −16 ).

There was a highly significant overlap of misregulated genes among the datasets as determined by Fisher’s exact test ( p = 4.9e-25 and 5.5e-10, respectively), despite the overall lower number of genes identified by microarray (Fig. 2b ).

The estimated variance of the random intercept was 0.177 (SD = 0.421), and the likelihood-ratio test indicated a highly significant random effect (χ 2 (1) = 106.44, P = 5.9 × 10 −25 ).

CON samples revealed a highly significant global difference in EVA values between CON and DEL progenitors ( n = 94 regulons, 3 sample of each genotype paired t-test p = 5.94×10 -25 ) with EVA( DEL-CON ) values showing a strong bias toward positive values ( Figure 4A ) indicating increased global gene expression variability in DEL compared to CON progenitor populations even in unrelated sets of genes.

We estimated the effect of number of life events on the risk of MDD by logistic regression and obtained a highly significant OR of 1.24 (95% confidence intervals 1.19–1.29, P = 6.49E-25).

With the specialized corpus, however, the paired t-test was highly significant ( p =6.8e-25), demonstrating that the quality of the ‘hybrid topics’ was better than that of the baseline topics.

Although the difference in variance in GC content between HGT and non-HGT trees was highly significant ( P = 7 × 10 -25 by unpaired 2-tailed t-test, n = 100 per sample), the optimal single-variable classifier [ 74 ] gave 21% false positives and 0.5% false negatives.

A contingency table analysis revealed a highly significant difference in genotype frequencies at the MC1R mutation site c.361G > A between the LSB and LSS populations (Fisher’s exact test, P = 8.268 × 10 –25 ).

We detected 16 putatively imprinted genes, of which 8 were also found Baran et al using a much larger sample size, a highly significant enrichment (OR = 4,049; P < 10 −24 ).

Second, genome-wide comparison indicates a highly significant inverse association of human-specific rearrangements with methylation levels (Kolmogorov-Smirnov test, D max = 0.23, p≈10 −24 ) ( Figure 1B ).

Firstly, as the source of this signature, the brown module’s gene set showed a highly significant enrichment in core processes such as the B cell receptor (BCR) signaling pathway (P=1.09e−24) and B cell activation (P=4.07e−17) in detailed pathway analysis.

Both the DLCV error as well as the error on the validation set show a highly significant correlation with the number of artificial datasets that is pooled, Pearson correlation of -0.91 ( p = 1.1 e - 24) and -0.95 ( p = 1.4 e - 31), respectively.

A test of homogeneity for the core matrisome proteins revealed a highly significant difference between native and dECM livers (χ 2 = 109.91, P = 2.76 × 10 −24 ), indicating that the relative abundance of core ECM components was markedly altered following decellularization.