Excerpts

A highly significant association was found between the two tests ( p = 6.09 × 10 −41 ).

Sets of DEGs between treatments were partially overlapping and we observed that the intersection of genes that differed between PMD and controls regardless of LCL treatment was highly significant (probability density p<6.49e −41 , Figure 2A ).

When normalized, manual analysis accuracy for N-T tissues increased from 0.75 to 0.91, which was highly significant (p=7,72x10 -41 ).

(A) motifs that are highly significant (Benjamini-Hochberg corrected p < 10 −40 , odds ratio > 10) are listed here.

mikatae analyses were highly significant, with hypergeometric p -values < 10 -40 .

Notably, dipeptides, such as Val-Glu and Met-Gln, showed highly significant values in AP ( p -value > 10 −40 ) ( Figure 3 ).

In Family A, SNPs on chr-4 at physical locations 62,076,809 bp and 62,076,876 bp exhibited the strongest association; additional highly significant SNPs (−log 10 p >40) clustered between 60,613,763 bp and the end of chr-4.

The SEA output includes an output ranking the proposed target/query interaction by probability (significant, p ≤ 10 –15 ; highly significant, p ≤ 10 –40 ) and by similarity score to an annotated compound/drug (Tanimoto coefficient, max Tc ≥ 0.40, max Tc 1.0 = exact match). 14 The SEA output ( Fig. 5 ) for our hit compounds was potentially informative in identifying additional potential targets for our most potent hit, niclosamide (KCNMA1 and TMPRSS4), as well as GSK-650394 (CAMKK2, AXL, RIPK1).

Other miRNAs were not ranked at the top 30 of comparative activity mode (Methods), however they show highly significant differential activity (corrected WRS p -value < 1 e −40) and substantial activity in at least one of the populations (activity p -values below 1 e − 4 among at least third of cells in at least one population).

The 6 most highly significant smoking CpGs were also the most highly associated with bladder cancer (smoking p -value < 10 - 40 , bladder cancer p -value < 10 - 10 ).

All differences in the prevalence of deafness between each endpoint were highly significant with all p < 10 −40 .

All correlations are highly significant (p < 1.0E-40).

The difference among three genotypes was highly significant both in males (p < 1E-40) and females (p = 1E-33).

(2016) , with a highly significant overlap in the composition of each defect group between cohorts (minimal P -value <1 × 10 −40 ; Fisher's exact test) ( Supplemental Fig.

The sequence alignment between the TYR residues 1–510 and the corresponding intramelanosomal domain sequence from the crystallographic structure of TYRP1 (residues 25–471) was calculated to have highly significant 3D structural similarity [sequence identity 45%, p = 10 −40 ( Abagyan and Batalov, 1997 ), Figure 1 ].

The PSs for TG (30 SNPs), LDL-C (28 SNPs), and HDL-C (60 SNPs) explained a relatively small, but highly significant, proportion of the variance (5.6 % [F = 157, P = 1.7 × 10 −40 ], 3.1 % [F = 99, P = 6.2 × 10 −27 ] and 5.1 % [F = 164, P = 1.1 × 10 −36 ]; Additional file 6 ) and were not associated with confounders (Additional file 7 ) with the exception of the HDL-C PS, which was associated with confounder neutrophil counts ( P value = 1.8 × 10 −2 ).

Category II SNPs (SNPs with less functional evidence than Category I) also showed highly significant enrichment for low P-values (fold enrichment 1.42; P = 2.60e-40) ( Table 3 ).

We found a large (n = 98) and highly significant (p = 2.8e−40) overlap between the splicing events regulated by QKI and RBFOX2 ( Figure 4 D).

When we compared the expression of all genes located within regions with significantly altered compartment scores, we observed a highly significant trend towards an increase in expression of genes with an increased compartment score and vice versa (Fig. 7a , top right; p = 2.99e-40).

The difference in the average number of trabeculae/embryo between mild and severe mutants was extraordinarily significant as determined via Student’s t -test ( P =4×10 −40 ).

Intima-Media Thickness and Genetic OAG Risk First, we validated the association between the OAG-GRS and OAG, which was highly significant ( P = 4.8 * 10 −40 ), with an OR of 2.44 (95% CI = 2.13–2.78) for each standard deviation increase in OAG-GRS.

This positive association is highly significant when compared to the whole population ( P = 7e‐40).

The difference in fit of the 13 models was highly significant ( p = 8 × 10 −40 , ANOVA), but there was no significant difference in the fits of the five top models, all of which incorporated a perseverative learning mechanism: Perseveration/Reward-learning model (PR model, ref. 36 ); differential forgetting Q -learning 33 ; ideal observer with perseveration (see Methods); ideal-observer Bayesian filters with perseveration for either a generic probabilistic reversal-learning task (see Methods), or a generic drifting reward probability task 37 .

Moreover, the SII demonstrated a consistent annual increase, with regression results indicating extremely significant statistical relevance (P = 9.3E−40).

The mean Pearson correlation between speed and HθWP after SAL and CNO injection were 0.44 ± 0.04 and 0.36 ± 0.07, respectively, reflecting a highly significant correlation in both cases (mean p < 10 −39 ).