Excerpts

P ‐value was reported as * p < 0.05 considered statistically significant, ** p < 0.01 considered highly significant, and *** p < 0.0001 very highly significant.

The coadministration of LMW-HA with naloxone and HMW-HA with naloxone were highly significant (p<0.0001); see Figure 5B .

Cox regression detected a highly significant constant temperature effect on post-storage germination (Wald χ 2 = 36.69, p < 0.0001).

The differences between groups A and B in the accumulated survival (Kaplan-Meier) were highly significant (log rank P value < 0.0001).

HDL-C Patients that died had a highly significant lower serum HDL-C on day 1 of ICU admission (p < 0.0001, meta-analysis t-distribution) with a pooled mean difference of −7.06 mg/dL (95% CI −9.21 to −4.91 mg/dL) across 17 studies with 1542 participants 17 , 20 , 22 , 31 , 32 , 34 , 36 , 37 , 40 , 41 , 43 , 45 , 46 , 47 , 48 , 50 , 51 ( Fig. 3 ).

All four models were highly significant ( p < 0.0001) with non-significant lack-of-fit tests ( p > 0.05), indicating adequate model fit.

Bonferroni-corrected post hoc pairwise comparisons were all highly significant: 0 vs. 5 wt% (Δ = −7.12 MPa, p < 10 −4 ), 0 vs. 10 wt% (Δ = −9.99 MPa, p < 10 −4 ), and 5 vs. 10 wt% (Δ = −2.87 MPa, p < 10 −4 ).

The difference in the mean distance of short-range connections using this method relative to those obtained using Procedure 1 (i.e., traditional correction) was highly significant ( p < 0.0001).

In both cases, the difference in the distribution of the individual cells among the classes of GFP intensities from the untreated and the Doxy-treated mice is highly significant ( p < 0.0001 by Chi square) ( Figures 3D , E ).

Moreover, a highly significant increase ( P = 0.0001) were found in serum uPAR level in T2DM with CVD as compared to those without CVD.

Remarkably, in this donor, the comparison between Δ C1R and Δ C1R-B51 showed a highly significant difference (*** p < 0.0001, Figure 7 B).

The difference between Control and Supplemented group was overall highly significant (effect of supplement, P < 0.0001), with a significant interaction with time (P < 0.0001) as the effects were mostly measured from d42 and even stronger at d49 and d56 (mean concentration were for Control and Supplemented group respectively, of 2.9 ± 0.2, vs 7.0 ± 0.4 Log 10 copies of 16S rDNA/g of rumen content at d49 and of 2.6 ± 0.3 vs 7.7 ± 0.3 Log 10 copies of 16S rDNA/g of rumen content at d56).

Stimulation of myoblasts with rIL-15 (25 ng/mL) induced a small (1.3-fold) but highly significant (p < 0.0001) increase in the expression of myomaker, a cell membrane protein that is essential for myoblast fusion (Fig. 1e ).

We observed that higher TSC correlated strongly with poorer outcomes and was highly significant with regard to disease progression when dichotomized at the median (median OS: 13 months vs 136, p < 0.0001 and median PFS: 5 months vs 85 months, p < 0.0001) ( Fig. 4 A and 4 B). p16-positive OPSCC have a proportionally smaller tumor stroma contact surface compared with p16-negative OPSCC We observed that the TSC was significantly higher in p16-negative OPSCC as compared to their p16-positive counterparts.

Temporal and Road Type-Based Trends of Raccoon Dog Roadkills Although highly significant (F 5,3229 = 25.0, p < 0.0001), the GLM model explained only 3.6% of the raccoon dog index variance.

A prespecified subgroup analysis (see Supplementary material online , Figure S6 ) demonstrated a highly significant interaction (χ 2 = 19.93; P < 0.0001), with a larger treatment effect in non-China studies (RR 1.30; 95% CI 1.23–1.38; I 2 = 0.0%) compared with China-based studies (RR 1.12; 95% CI 0.96–1.29; I 2 = 0.0%).

Along with expected improvements in clinical and lung function parameters brought by Mepolizumab treatment, FEF2525-75% values showed a highly significant, gradual and persistent increase (from 32.7 ± 18.2% at baseline to 48.6 ± 18.4% after 18 months) and correlated with ACT scores at 18 months (r = 0.566; p ≤ 0.0001).

Furthermore, administration of enteral nutrition led to a significantly shorter delay in peristalsis recovery compared to the unfed group with a mean duration of 2.1 (0.6) days and 3.8 (1.2) days, respectively; this difference was highly significant ( p value < 0.0001).

Statistical analysis revealed the differences in prevalence between breeds were highly significant ( p < 0.0001), indicating a strong breed-associated variation in susceptibility or colonization by S. epidermidis . 3.4.

A highly significant reduction in the expression levels of the target genes, with a p -value of < 0.0001 compared to the control, was detected for both tested isolates C6 and C21.

This difference was statistically highly significant (p = 0.0001) (Figure 5 ).

Effect of nymphal age on the spirochete load of infected nymphs The mean spirochete load of the 1-month-old nymphs ( n = 43, mean: 14,094, 95% confidence interval (CI): 13,508–14,705 spirochetes per nymph) was 7.05 times larger than that of the 4-month-old nymphs ( n = 42, mean: 1999, 95% CI: 1900–2103 spirochetes per nymph) and this difference was highly significant ( t = 12.768, df = 41, P < 0.0001).

When compared to healthy people of the same age, the proportion of peripheral immune T cells in tumor patients in the young, middle-aged, and elderly groups showed a significant trend of decline (P <0.0001), and the proportion of T cells in the tumor group gradually decreased with age (young 48.12%, middle-aged 46.09%, and elderly group 43.16%) ( Fig. 3 A ).

Change in bodyweight, but not epididymal fat mass, had a significant effect on xenograft mass (P = 0.0069), but the effect of treatment was still highly significant (P < 0.0001) and the differences between groups treated with vehicle, HI or IX10 were fully comparable to the effects observed when the effect of bodyweight was not included in the analysis (Supplementary Table S4 ).

A 2x2 Fisher test revealed a highly significant association between reactivity to adduct and to apoptotic cells for Thy A (p<0.0001) and Thy C (p=0.0024).