Excerpts

When all absolute raw ITVs (900) were correlated with respective area values a highly significant inverse relationship was observed ( r = - 0.125, p = 0.000169).

The results from the linear regression model, adjusted for age and sex covariates, yielded several nominally significant variants in the PTPN2 region including the top finding of rs78943928 ( p = 1.69E−04) which resides approximately 29 and 22 kbp 3′ of PTPN2 isoform 1 and isoform 2, respectively.

Further, the purple module showed a highly significant positive correlation with POD ( r = 0.77, p = 0.00017), indicating that the accumulation of purple module transcripts was associated with an increase in POD activity.

Disease had a highly significant ( p = 0.00017) impact on cell composition and steroid use was marginally significant ( p = 0.04680).

This established a statistically highly significant association between hyponatremia and hypertriglyceridemia in our ALL cohort (p = 0.00017, Table 2 ).

This analysis revealed a highly significant 8-fold reduction in the LacZpositive surface area in mutant samples (Sox9Δ/+-LacZ: 6.65 ± 1.77%; Sox9Δ/Δ-LacZ: 0.85 ± 0.85%; paired t-test, p = 0.00017; Figs. 6E and F; Table S12).

Results The results of the rt-PCR analysis showed significant differences in the RNE (Relative Normalized Expression) level of the Firmicutes phylum ( p = 0.048) and highly significant in the level of the Lactobacillaceae family ( p = 0.00017) between the lambs and bulls.

Furthermore, among these 2137 samples previously assessed, we confirmed a highly significant association between ddPCR-estimated AMY1A copy number and lower BMI (β = –0.0043 ± 0.0011 kg/m 2 per AMY1A copy, P = 1.7 × 10 −4 ; Additional files 9 and 10 ).

When data of lepidosaurs, turtles and crocodylians are combined, a weak but statistically highly significant correlation emerges (area: adjusted R 2 = 0.104, p -value = 0.00017, df=120; length: adjusted R 2 = 0.3373, p -value <0.00001, df = 178; Fig. 4 ).

The Pearson correlation of log-transformed variables was weak but statistically highly significant (0.348, p < 0.000171).

These loci were only nominally significant in the analysis including the svPPA patients ( LRP1B : P = 1.72 × 10 −4 ; OR = 4.66, COL22A1 : P = 0.03; OR = 5.32; TMEM135 : P = 1.68 × 10 −3 ; OR = 2.19, and TRPC4 P = 1.25 × 10 −4 ; OR = 2.91).

It is interesting to note, however, that H3 tSNPs approached significance for protection against degeneration of the macula and the posterior pole of the retina ( p = 1.76E−4–9.49E−4, OR = 0.91; Table S19 ).

This finding was highly significant (P=1.78×10 −4 ) in the combined meta-analysis with a 3.05-fold increase in risk of esophagitis (95% CI=1.70–5.57).

Combined analysis of all samples investigated (2,966 cases, 10,556 comparison subjects) produced highly significant evidence that duplications at 15q13.3 are associated with ADHD (p=0.000178; odds ratio=2.22, 95% confidence interval=1.46–3.38).

This preference was highly significant (binomial test, p = 0.00018).

Fisher’s Exact test (two-tailed) on the frequency of LOF and nonsynonymous variants associated with 46,XX DSD observed in our cohort, compared with rare (Minor Allelic Frequency [MAF] < 0.01%) LOF and nonsynonymous variants in the WT1 gene from control individuals, shows a highly significant enrichment of these WT1 variants in the patient cohort ( P < 1.8 × 10 −4 ).

The relationship between pH and NF-κB p65 expression was explored by linear regression and a highly significant effect observed [ F (1,5) = 98.3; p = 0.00018; Figure 4 B].

A one-way ANOVA analysis showed a highly significant effect of origin on CI at the end of the winter conditioning (week 9) (F = 15.95, p = 0.00018).

Control comparison, M6 showed highly significant elevation (FDR-adjusted p = 0.00018), followed by A2BG1S1 (FDR-adjusted p = 0.0062) and M5 (FDR-adjusted p = 0.0296).

In contrast, V-SO 2 % showed a stronger and highly significant positive correlation with ST V ( r = 0.70, p = 0.00018).

Additionally, though not quite statistically significant after correcting for multiple testing, HLA‐DPB1*06:01 was associated with a lower middle frontal LB count (Multiplicative effect = 0.40, p = 1.80 × 10 −4 , Supplementary Fig. 1 ), HLA‐DRB1*11:01 was linked to a lower Thal amyloid phase (≥3: 44.7% vs 74.8%, OR 0.34, p = 1.56 × 10 −4 ), HLA‐DPB1*06:01 was associated with a lower inferior parietal LB count (multiplicative effect = 0.41, p = 6.33 × 10 −4 , Supplementary Fig. 1 ), and HLA‐B*15:01 was linked to an increased risk of diffuse LBD (85.7% vs 67.2%, OR 3.43, p = 7.58 × 10 −4 ).

Using the mean coverage rate of CLIP-identified mRNA targets (including the flanking 15 nt) as the expected probability to perform a binomial test, we found that the coincidence of 193 predicted piRNA target sites relative to CLIP-identified targets within 169 genes was highly significant ( P = 0.00018).

This difference was highly significant ( Figure S5 B, Wilcoxon signed-rank test, p = 0.00018, n = 18 sessions in 2 monkeys), suggesting that the eyes were very stable in the time interval of interest.

Those associations proved to be highly significant ( p = 0.00018).

In a Δ mutS strain, the protection is stronger and highly significant ( p = 1.8 × 10 −4 , U = 124.0, corresponding to 72% of mutations that are avoided): this is qualitatively consistent with our theoretical prediction that the protection is higher when the mutation spectrum is biased towards frameshifts ( Fig 2 ).