Using KD data for this gene, we find that there is a highly significant decrease in the cleavage ratio in KD samples compared to controls ( P = 0.00018, one-tailed t -test, mean control ratio = 0.125, mean KD ratio = 0.066, Fig. 3 ), suggesting that RPS19 may be modulating RNA processing at this site.
Excerpts
In contrast, V-SO 2 % showed a stronger and highly significant positive correlation with ST V ( r = 0.70, p = 0.00018).
The relationship between pH and NF-κB p65 expression was explored by linear regression and a highly significant effect observed [ F (1,5) = 98.3; p = 0.00018; Figure 4 B].
The Breusch–Pagan test was highly significant (BP = 13.978, df = 1, p = .0001849), rejecting homoscedasticity (Figure 3b ).
As demonstrated in the table, patients requiring both pre- and postoperative transfusions have a significantly higher risk of mortality compared to those without transfusions (HR = 5.97, p = 0.00019, highly significant).
Log-rank analysis showed a highly significant difference between the two groups ( P = 0.00019), indicating that the CPVI + PLUS strategy was more effective in reducing AF recurrence ( Figure 2K ).
This showed a highly significant positive relationship ( r = 0.83, p = 0.00019) between the two variables.
Reassuringly, the association with a clinical diagnosis of “vitamin D deficiency” (ICD-10 E55; N cases = 3150, N noncases = 344,619) was negative and nominally significant (i.e., higher DBP associated with a reduced risk of a clinical diagnosis of vitamin D deficiency; beta = −0.07, standard error = 0.02, P value < 1.9 × 10 −4 ).
Linear regression analysis showed that the slope of the line was not significantly different from zero for normal Aβ degradation when the threshold is four but it was highly significant ( p = 0.00019) for the AD degradation rate (Figure 4 A, B).
The interaction between MLEC and TMEM59 was highly significant ( p = 0.00019, β = 2.469), with higher expression of both genes correlating with increased predicted probabilities ( Figure 10I ).
When we considered PI, however, categorized at the cutoff of 2.4, the statistical association was highly significant (p = 0.00019), and we observed discrete values of sensitivity (29.41%) without losing too much in specificity (88.19%).
Cluster 35 shows a highly significant enrichment for genes associated with gene ontology (GO) terms involving neurogenesis (Additional file 8 : Table S2, P = 1.91 × 10 −4 ) consistent with the peak and decline of neurogenesis from E12.5 to 16.5.
The dose and response exhibit a significant trend (at the 0.05 level) for both datasets (one-tailed Cochran-Armitage test 31 , n = 6 and P value = 1.91 × 10 −4 for DS1, n = 11 and P value = 1.11 × 10 −5 for DS2).
The results were conclusive: only IL-18R1 maintained a highly significant direct causal effect on AD (β = 0.023, P = 1.92 × 10 −4 ), whereas the direct effects of both PA-GPC ( P = .074) and IL-18 ( P = .084) became non-significant.
borderline significance-Log 10 P -value=3.71
In contrast, rs4304220 on chromosome 7 (6,243 SNPs) showed borderline significance: it was significant for RSB ( RSB =3.55, -Log 10 P -value=3.71) and near-significant for XP-EHH ( XP-EHH =1.33, -Log 10 P -value=1.04), also with positive values pointing to recent positive selection in the HC group ( Fig. 3 B).
A t-test was also performed to validate significant enrichment of repetitive elements in the intergenic regions which gave a highly significant p-value for the enrichment of repetitive elements in the intergenic regions (p-value = 0.0001957 in S . tuberosum and p-value = 6.018e-11 in S . lycopersicum ).
These correlations were highly significant ( p < 1.96 × 10 − 4 ).
approached significance-Log(p-value) = 3.7
The false negative chemical mefenamic acid approached significance (-Log(p-value) = 3.7) and exhibited a pattern in which all but one of the 11 altered genes were directionally consistent with the biomarker.
close to significance− log10 p = 3.7
In this case, however, another SNP (JHI-Hv50k-2016-151,847 “4.6 cM”) in a close location was close to significance (− log10 p = 3.7) for variety age in the same region (Figs.
Smaller but highly significant increases in IL‐6 (32.2 pg/mL vs. 21.9 pg/mL, p = 0.0002), IL‐8 (55.6 pg/mL vs. 41.7 pg/mL, p = 0.007), and IP‐10 (1.2 ng/mL vs. 1.0 ng/mL, p = 0.04) were detected in cachectic patients.
In Model 2 (NB Regression with Region), only episodes remained highly significant (β = 0.00505, SE = 0.00137, z = 3.69, p = 0.0002), while latitude became marginally significant ( p = 0.096); area lost significance ( p = 0.119).
In addition, a weak yet highly significant positive correlation (rho = 0.49, p -value = 0.0002) was found between the overall metabolite load and the cell size during the growth phase ( Figure 5B ).
Biological process annotations of these genes showed highly significant enrichment for lipid metabolism genes (P = 0.0002).
The final model had a highly significant (p = 0.0002) likelihood.
In general, the difference in CYP2W1 expression between normal tissue and primary tumours was highly significant (P ≤ 0.0002).