Excerpts

Relative gene expression Expression of cannabinoid receptor 1 (CB1R) is increased after ELS and FS Two-way ANOVA analysis revealed no significant main effects for ELS [ F (1,31) = 0.5555, p = 0.4617] or FS [ F (1,31) = 0.2117, p = 0.6487], but a highly significant interaction between these two stressors was found [ F (1,31) = 18.48, p = 0.0002].

Based on statistical analysis, results show a strong highly significant influence effect of the harvesting year ( p = 0.0002) on DON content, which is more than doubled for the harvesting year 2020 (mean of 3746 μg kg −1 vs. 1463 μg kg −1 ).

This difference in nodal metastasis as per subsite was highly significant (Chi-square = 19.410, degrees of freedom/d f = 5, p = 0.0002).

The difference was highly significant ( P = 0.0002, Student t test, 2-tailed).

Interaction terms X1X2 ( p = 0.0285) and X2X3 ( p = 0.0202) were moderately significant, with X2 2 showing a non-linear impact ( p = 0.0002).

The difference was highly significant (P = 0.0002).

The PRC diagram (highly significant, pseudoF = 52.3, p = 0.0002, Fig. 5 ) clearly demonstrated the responses to experimental manipulations.

Surprisingly, there was a U-shaped relationship with increased AF disease status, such that PITX2c expression was higher in subjects with no history of AF, lower in AF/SR subjects, and higher again in AF/AF subjects, with this difference highly significant (p = 2×10 −4 by non-parametric Kruskal-Wallis ANOVA) ( Figure 3A ).

This increase starts already at birth, remains constant throughout childhood s as shown by other groups ( 4 , 9 ) results in relative increase of the memorand adolescence, and is highly significant (linear regression intercept p = 0.0002, slope p = 0.54) (Figure 1 C). cTFHs Are Expanded in DiGeorge Syndrome To correct for the relative increase of memory CD4 + T cells in DiGeorge, we compared the percentages of CXCR5 + memory CD4 + T cells (cTFHs) of all memory CD4 + T cells (gating strategy shown in Figure 2 A).

There is an extremely significant Spearman’s rank correlation with k for age at peak incidence rate, both model-fitted (both: Spearman’s ρ = 0.74, P = 0.0002, n = 21; female: ρ = 0.68, P = 0.0002, n = 25; male: ρ = 0.73, P = 0.0001, n = 23) and from the SEER data (both: ρ = 0.62, P = 0.003, n = 21; female: ρ = 0.66, P = 0.0003, n = 25; male: ρ = 0.47, P = 0.02, n = 23).

In general, the difference in CYP2W1 expression between normal tissue and primary tumours was highly significant (P ≤ 0.0002).

The differences between the populations are highly significant for both Cmax values, as determined by 3-group permutation ANOVA (p < 0.0002 for both) and pairwise Wilcoxon test for sparse vs dense (p = 2e-18 and p = 9e-14 for Cmax = 90 nM and 900 nM, respectively).

The degree of the functional overlap across the six BR-signatures is highly significant (P = 0.0002) under a bootstrapped null distribution.

A highly significant (P = 0.0002) increase in the rate of malsegregation affecting structurally normal chromosomes was observed in association with Robertsonian translocations.

Methodological Quality Methodological quality as assessed by the Jadad score increased significantly over time (P<0.0001); we also reanalyzed the data minus the first period (1948–1953) (where the average Jadad score was much lower) and the increase over time was still highly significant (p = 0.0002) ( Figure 4 ).

Cytotoxic effects of 5′DFUR, and to a lesser extent those of 5FU, were enhanced in TP clones as compared to control cells: there was a highly significant correlation between TP activity and in vitro sensitivity to 5’DFUR (r 2 = 0.91, P = 0.0002, n = 8) and, to a lesser extent, to 5FU (r 2 = 0.49, P = 0.053, n = 8).

SLN status did not impact the prognostic strength of this risk score, since after stratifying by SLN status, the gene signature risk score remained highly significant ( p = 0.0002) ( Figure 3 ).

There was highly significant difference on RI value at day 14 in dogs graded on day 1 of the trial as nonambulatory paraparetic versus paraplegic ( P = .0002), but treatment group remained not significant because of equal distribution of these grades between groups ( P = .73). 3.2.

As shown in Figure 4C , the differences approached significance in the case of isoform B (t = −1.97, p = 0.059) and were highly significant in the case of isoform C (t = −4.31, p = 0.0002).

The correlation between the number of BS and gene transcription levels was markedly significant (Supplementary Fig. 10c , p = 0.0002; Pearson correlation analysis).

The difference between the cells infected with TTSuV1 and cells transfected with the unrelated DNA was highly significant at p = 0.0002 ( Fig. 2 ).

The final model had a highly significant (p = 0.0002) likelihood.

This was a highly significant difference ( p = 0.0002).

This difference is highly significant (p = 0.0002, chi-square test). 4.

Correlations computed within each group further strengthen the distinct AD vs HC responses, showing a clear trend within the former group (Spearman rho < −0.92, p < 0.0002, FDR < 0.003, n = 10) but no statistically significant relationship in the latter (Spearman rho = 0.39, p > 0.38, FDR > 0.38, n = 7).