8 , 9 The strongest and most highly significant associations have been reported with early-onset, persistent eczema 10 , 11 (odds ratio 5·6, 95% confidence interval 4·1–7·8, P = 1·3 × 10 −28 ) and asthma occurring in individuals with atopic eczema 12 – 14 (odds ratio 3·49, 95% confidence interval 2·00–6·08, P = 1·0 × 10 −5 ).
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The rs334 SNP, when directly genotyped, was highly significant ( P = 1.3 × 10 −28 ), whilst the best marker in the GWAS SNPs ( P = 3.9 × 10 −7 ) did not reach genome-wide significance.
Using the complete variant dataset, we found a highly significant difference in the distribution of distances between intra-individual and inter-individual samples (Wilcoxon test, HaplotypeCaller: p = 1.31 × 10 –28 , Mutect2: p = 1.51 × 10 –28 ) ( Figure 5B ).
Comparison of Models 1 ( α = β 1 = β 2 = 0) and 2 ( α = 0) in Table 2 reveals a highly significant offspring SE allelic effect on RA risk ( χ 2 2 = 128.1, p = 1.5 × 10 -28 ).
The scores only explained 3% of the variance in schizophrenia case-control status, but the large sample sizes ensured that this was highly significant (up to P = 2 × 10 −28 ).
However, only for HNF1β (HNF1B_MOUSE.H11MO.0.A, [ 14 ]) we found the extremely significant asymmetry within predicted CEs toward the partner motif ( p < 2 × 10 −28 and p < 4 × 10 −17 for CEs with an overlap of motifs and with a spacer, respectively).
Instead, we observe that an increase in STAT3 binding is correlated with an increase in expression in most of these pairs (83%, n = 686), an association that is highly significant at P = 2.3 × 10 −28 ( Table 4 ).
The type of incubation fluid exhibits a highly significant impact on the sorption ability, as indicated by an exceptionally low p -value ( p = 2.45 × 10 −28 ), suggesting that the fluid type strongly influences the swelling behavior of hydrogels.
However, although the difference in terms of percent variation explained in RBC by SSCCA vs SSMCCA methylomics CV1 is highly significant (p-value = 3E-28), the absolute difference (4.27E-8 percent variance explained) is tiny, suggesting the difference between the performance of two methods is negligible.
An Amino Acid Permease gene, CsAAP2A (gene ID: Csa4M573860), was selected as a promising candidate gene based on the finding that this gene was down‐regulated by a factor of 100 in NIL DM4.1.3 compared to HS279, which was highly significant (Benjamini–Hochberg corrected p value = 3.1 × 10 −28 ). 2.2 Lack of CsAAP2A expression is due to the insertion of a CUMULE transposon To investigate the reason why CsAAP2A was very poorly expressed in NIL DM4.1.3, we resequenced the whole genomes of genotype NIL DM4.1 (an NIL with an introgression spanning subQTL DM4.1.1, DM4.1.2, and DM4.1.3) as well as susceptible parent HS279.
We found highly significant negative genetic correlations between sociability and ASDs ( r g = −0.27, p = 3.6e−28), MDD ( r g = −0.67, p = 4.5e−249), and SCZ ( r g = −0.15, p = 7.5e−23).
Sex-related tissue specificity One network specific to histologically normal tissue (Normal: lavenderblush3) featured a highly significant relationship with biological sex (bicor 0.82 P = 3.72 × 10 –28 , n Obs = 113, see Supplementary Fig.
As shown in Table 2 , the DEGs from the Rat in vitro model (Rat-DEGs) exhibited a high correlation with those from the Human in vitro model (Human-DEGs), sharing a highly significant gene overlap ( P = 4.02E-28).
rs13038305 in Relation to Cystatin C At baseline each copy of the major allele of rs13038305 was associated with a highly significant approximately 0.30 standard deviation (SD) higher plasma concentration of cystatin C both in model 1 (β = 0.33, p = 4.2E-28) and model 2 (β = 0.33, p = 1.7E-29).
In PRAD, the correlation between DRD1 expression and immune purity was highly significant (correlation = 0.502, p = 4.93e−28), and a similar pattern was noted for immune cells (Fig. 7 c) .
Although the MHC association is highly significant in both OLP and non-OLP, it is dramatically stronger in non-OLP ( p = 5.6 × 10 −28 for difference in effect), and the association in non-OLP near CLEC16A does not even reach nominal significance in OLP.
Results Broad depression phenotype with self-reported MDD The genetic correlation ( r g ± SE) between the broad depression phenotype and self-reported MDD in the 23andMe data, calculated using the LD Score regression method, was 0.79 ± 0.07 and highly significant ( p = 5.70 × 10 –28 ).
Expectedly, a highly significant naming deficit became obvious for LIP in comparison to HIP (p=7.0×10 -28 ) and healthy controls (p=9.1×10 -29 ) (Figure 2 C).
In the offspring cohort, the spouse correlations were lower but still highly significant for PC1 (r = 0.38, P = 7x10 -28 ) and for PC2 (r = 0.45, P = 2x10 -39 ).
In general a highly significant correlation between miR-122 expression levels and target gene perturbation was observed in HCC samples ( p = 8.1 × 10 −28 ).
Inception-v4 consistently ranked last, with an accuracy of 87.42% and an AUC of 94.24%, and exhibited highly significant disadvantages compared with all other models ( p < 10 − 27).
However, only the primary angiosarcoma specimen, AS1, exhibited a prominent and highly significant ( P <10 −27 ) expression transition ( Figure 2A ), with the predicted breakpoint corresponding to known rearrangements of ROS1 in other malignancies.
The results with GENECONV (Table 1 ) were highly significant (p values < 10 -27 -10 -66 ) between the paralogues of the same species in groups 1, 2 and 3 providing evidence of gene conversion between ancestral sequences of paralogues.
This 14-fold increase of gene numbers regulated by HPV E7 in addition to E6 among pocket protein target genes is highly significant ( P < 10 −27 ) and thus substantiates the model that p53 can directly activate its target genes while p53-dependent repression largely occurs via the p53-p21-DREAM/RB pathway.
Above all, in all GO analyses there was a highly significant enrichment in the term ‘testis’ for the tissue category (p < 10 −27 ), indicating that most DE coding genes that are co-expressed with lncRNAs along spermatogenesis are testis-specific.