Excerpts

Survival analysis confirmed the highly significant impact of IL-6 (P = 8.56e−23) on the survival of COVID-19 patients and also identified a nominally significant effect of IL-2R on survival (P = 0.0003, Figure S1 , Table S1 ).

The genetic principal component PC4 was highly significant log(HR) = 3.4 × 10 −2 , p = 9.2 × 10 −23 .

Moreover, as anticipated, differences between the mean pH values of the n = 6 participants included in this phase of the study were indeed very highly significant ( p = 9.42 × 10 −23 ), with ranges in their mean values being 5.49–6.37.

This difference was highly significant (Wilcoxon rank-sum test, p = 9.46 × 10^-23).

This difference is highly significant ( t -test, p -value < 10 −22 ) and clearly demonstrates the improvement of the pop-out recombination step or the counterselection step with 6-MP. 3.5.

Both effects remained highly significant after spike rate equalization ( Supplementary Fig. 3b,d online; P < 10 −22 , Wilcoxon signed-rank test, n = 166 neurons from 19 experiments).

Cuzick’s test for linear trend showed that these median LRS values were linearly related to the T2D status and highly significant ( p < 1.0x10 −22 ).

Strikingly, we found that 41.9% (1328 out of 3173 sites) were edited at significantly higher levels in the brain than in non-brain tissues ( P < 0.05, Wilcoxon test), which represented a highly significant enrichment for brain-specific editing compared to various negative controls (see ‘Materials and Methods’ section) ( P < 1 × 10 −22 , Fisher’s test) (Figure 5H and Supplementary File S1 ).

The enrichment for suspected translationally repressed transcripts among the dysregulated proteins of the P clag - cdpk1-gfp was highly significant (p < 10 −22 ).

Statistical validation of these compositional shifts using chi-squared tests revealed highly significant alterations across all comparisons ( p < 10–22), with effect sizes ranging from moderate to very strong (Cramér’s V = 0.29–0.56).

In the final combined analysis, there was highly significant evidence for association with MS in this region ( p = 1.1e− 22).

Friedman tests consistently ranked FW-CAGIN first (mean rank = 1.0 across all features and datasets; Appendix B , Table B6), with highly significant differences (χ 2 = 73.73–105.21, p < 1.18e−22; Appendix B , Tabke B4).

First, an analysis of expression levels using RNA-seq data from the Maize Gene Atlas [30] reveals a small (∼20%) but highly significant depletion of low-expressed genes (p = 1.30×10 −22 by Mann-Whitney test and ≈0 by Kolmogorov-Smirnov test) ( Fig. 6 ).

Correlation analysis using TCGA database (N = 1,082) across all breast cancer subtypes revealed a highly significant association between ErbB2 and BLVRB expression (ρ = 0.291, p = 1.30 × 10 −22 , Fig. 6 L).

The significant association between assessment patterns with readiness to feed was demonstrated by a highly significant χ 2 test result, which was 95.68 and p < 1.35 e − 22 for 2 clusters (ready to feed vs. not ready).

To validate our networks, we determined whether our NBIA-containing modules are composed of the same genes as those in publicly available caudate nucleus networks ( Oldham et al., 2008 ) and identified a highly significant overlap between these two basal ganglia networks (e.g. our brown module vs their M16C module: p = 1.38 × 10 − 22 ; our green module vs their M9C module: p = 2.69 × 10 − 166 ).

This revealed a highly significant relationship between the level of methylation of the CASP1 promoter and CASP1 mRNA expression in ALL cells (p = 1.4 × 10 −22 ; Fig. 1F , Supplementary Fig. 2 panels A–C ).

The upstream regions of 17 mid-meiotic internal TSS were found to contain MSE sites ( Table 3 ), an extremely significant enrichment (p<1.5x10 -22 , Fisher's exact test).

This overlap is still highly significant, although less striking than in SAT (p = 1.6 × 10 -22 ; Fisher's exact test assuming that 20,000 different genes were tested).

The DML overlap between the two cohorts was highly significant ( p = 1.71 × 10 −22 , 8.17 × 10 −33 and 3.13 × 10 −44 in B cell, memory T cell and Naïve T cells, respectively, by hypergeometric tests).

Among the IFN -inducible genes, HLA-DPA1 , PSMB8 , PSMB9 , TAP1 and TAP2 were proximal to rs3129750, a highly significant genetic variant associated with TB ( P = 2.51e-22), providing genetic support for these genes as potential host targets.

Educational Resources also presented a highly significant effect ( p = 2.8 × 10 −22 ), with a moderate degree of association between categories ( φ c = 0.439), and the same was true for ESAR Facets ( p = 5.15 × 10 −16 ; φ c = 0.366).

Restricting to individuals with Asian or European ancestry, we confirmed a highly significant increase in EGFR mutation rate in tumors from individuals with Asian ancestry (18% in samples of European ancestry; 57% in samples of Asian ancestry; p = 3 × 10 −22 by logistic regression).

Firstly, there is a highly significant correlation between the measured binding data and the predicted homophilic binding strength (Pearson’s r = 0.86, p ≅ 0 and Spearman’s r = 0.81, p = 3.03e-22, Additional file 2 : Table S3).

Analyzing the same brain regions from another group of mice using our custom array platform revealed another highly significant CpG to be hypomethylated in the Q175 group (probe cg12389415 on the custom array, mouse chr5:34795955) also within the Htt locus (meta-analysis p = 3.2 × 10 −22 ; Supplementary Fig. 25 ).