“a near-significant trend”

The exposure of endothelial cells to monodansylcadaverine did not reduce the uptake rate of ApoExos or ApoBodies but did reduced transferrin, a protein known to enter cells through clathrin-dependent endocytosis, and ExoN to a near-significant trend (Fig. 3A ).

In all statistical analyses, differences were considered significant at p < 0.05; p < 0.1 was considered to indicate a near-significant trend. 3.

Differences were considered significant when P < 0.05, whereas P < 0.10 were considered a near-significant trend.

Differences were regarded as significant at p ≤ 0.05, while 0.05 < p ≤ 0.10 was considered a near-significant trend.

A T-probability of p ≤ 0.05 was considered statistically significant, while 0.05 < p ≤ 0.10 indicated a near-significant trend.

Differences were considered significant at P < 0.05; P < 0.1 was taken to indicate a near-significant trend.

We also observed a near-significant trend in cold-induced changes in supraclavicular skin temperature (η 2 = 0.113, P interaction = 0.086; Fig. 5 j).

Probabilities of p ≤ 0.05 were significant and 0.05 < p ≤ 0.10 were a near-significant trend.

However, we did find a near-significant trend of decreasing APTT, which may hint that despite the neutral findings in the TEG-measurements, the intrinsic cascade may be affected, which is in alignment with earlier research [ 26 , 27 ].

However, post-hoc analyses demonstrated (1) a significant improvement in true local recurrence rates with pre-operative RT; (2) a potential loss of statistical power to detect abdominal recurrence free survival (ARFS) benefit due to poor RT protocol compliance; (3) a near-significant trend towards ARFS benefit for patients with well-differentiated liposarcomas and other low-grade histologies, a trend which achieved statistical significance on inclusion of an expansion cohort [ 11 – 13 ].

A near-significant trend for female sex was also noted.

Probabilities ( P ) of ≤ 0.05 were considered statistically significant, whereas values of 0.05 < P < 0.10 were declared a near-significant trend.

Significance was declared at p (probability) < 0.05, and 0.05 ≤ p < 0.10 was considered a near-significant trend. 3.

Although this suggests a near-significant trend, the result is not statistically significant.

In the present study, however, UKA only showed significantly higher walking speed and range of motion in the early acute phase, with a near-significant trend favoring UKA in overall walking speed trajectory.