Barely Significant
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a numerical trend

709 sentences · 709 papers · 1,651 search hits before verification · confirmed specimen

Sighted at

p=0.09

Listed by Hankins (2013) · Otte et al. (2022)

In the literature

Notably, a numerical trend towards inferior outcomes was observed in highly immunogenic brain metastases characterized by combined adenosine pathway activation and high PD-L1 expression (adenosine high/PD-L1 high), which may indicate a clinically relevant high-risk phenotype and further underscore the unmet medical need for an expansion of immunotherapeutic strategies in brain metastases.
Furthermore, within lysis time Q4 (2940 to 11 302 s), there was a numerical trend towards higher rates of cardiovascular events with increasing lysis time on adjusted analysis ( Figure 3 ) that was consistent with previous findings in ACS patients and warrants future scrutiny of those with very high lysis times.