Notably, a numerical trend towards inferior outcomes was observed in highly immunogenic brain metastases characterized by combined adenosine pathway activation and high PD-L1 expression (adenosine high/PD-L1 high), which may indicate a clinically relevant high-risk phenotype and further underscore the unmet medical need for an expansion of immunotherapeutic strategies in brain metastases.
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“a numerical trend”
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In the current study, statistical differences were not recorded for organ weights of the heart ( p = 0.0739), liver ( p = 0.0614), kidney ( p = 0.3179), or spleen ( p = 0.1892) measured during goat harvest ( Table 3 ), although a numerical trend occurred for heart and liver weights as supplementation of biochar increased.
Although a numerical trend toward shorter PFS was observed with worsening LIPI categories in our cohort, this difference did not reach statistical significance.
Additionally, a numerical trend was also observed for domain 2 (OR: 1.56, 95% CrI: 0.97 to 2.54).
Discussion In this randomised controlled trial, adjunctive silodosin after ESWL did not achieve a statistically significant improvement in the primary endpoint of overall SFR compared with standard care, although a numerical trend towards higher clearance was observed.
The retrospective analysis reveals a significant reduction in treatment burden that was previously described only as a numerical trend.
While both groups engaged in the phonemic fluency task, children with HFA showed a numerical trend toward reduced verbal output ( Table 1 ).
While diet did not significantly influence microbial diversity ( p > 0.05), a numerical trend was observed, with the MS:100 diet showing the highest Shannon diversity index (1.66 ± 0.11) and the commercial concentrate exhibiting the lowest (1.13 ± 0.40) numerical diversity.
No significant interaction was observed by device type, although a numerical trend favored Impella support in women.
Interestingly, although PTS changes did not differ significantly, both OWDTO groups showed a numerical trend toward greater slope increases.
After propensity score matching, the association was attenuated and did not reach statistical significance (β = 0.26 [95% CI, −0.01–0.52]; p = 0.061), although a numerical trend toward longer procedural duration in the GA group persisted.
Nonetheless, adjusted means indicated a numerical trend toward higher Pparg expression in NW-MSCs compared to OW/OB-MSCs by day 14 of differentiation ( Figure 1E ).
There was a numerical trend in favor of PFB 0.01% in terms of presence of conjunctival hyperemia and CFS at Week 6 and Week 12.
However, a numerical trend toward higher rates of mycological eradication was observed in the rezafungin group both on day 5 and day 14.
Furthermore, within lysis time Q4 (2940 to 11 302 s), there was a numerical trend towards higher rates of cardiovascular events with increasing lysis time on adjusted analysis ( Figure 3 ) that was consistent with previous findings in ACS patients and warrants future scrutiny of those with very high lysis times.
Pre-conception recurrence occurred in 17.8% of medical therapy patients versus 8.2% of LNG-IUS patients (SHR 0.42, 95% CI 0.13–1.38, p=0.15), demonstrating a numerical trend toward lower recurrence with LNG-IUS that did not achieve statistical significance in our sample size.
Although this difference did not reach statistical significance, a numerical trend toward improved outcomes in PNH-positive patients was observed.
In terms of lying postures, heat-stressed buffaloes showed a numerical trend toward more frequent vertical lying compared with animals under thermoneutral conditions.
Although bergapten was not significant, it still showed a numerical trend of activating AHR and NRF2, and is a potential dual agonist.
22.1 months, respectively; p = 0.3865), although a numerical trend toward lower relapse rates was observed in subjects with late (33.3%) or early and late dose reduction (37.5%) compared to those who had dose adjustment only at the first re-evaluation (75%) ( p = 0.3014).
Moreover, a numerical trend towards fewer DOCE events was observed when comparing the hybrid vs. full-DCB groups; however, this finding should be interpreted with caution given the low number of events and the limited statistical power of the study.
Although MinPf showed a numerical trend toward a between-group difference, this difference did not reach statistical significance ( Table 3 ). 3.2.
Conclusion In this retrospective cohort, hook fixation was associated with a lower incidence of PJF, while vertebroplasty showed a numerical trend toward reduction that did not reach statistical significance.
reported a complication rate of 5.3% in individuals with BMI ≥ 60 kg/m2, with no significant difference between LSG and LRYGB, although a numerical trend favored LSG [ 41 ].
Similarly, it is possible to observe a numerical trend in favor of the prepectoral position regarding the CC rate, even if the data did not reach statistical significance.