“did not reach statistical significance”

However, in the multivariate analysis, the association between ADAPT and functional outcomes did not reach statistical significance, although a near-significant trend was observed.

Aggressive ROP (A-ROP) (OR = 3.009, p = 0.106) and a history of systemic surgery (OR = 2.293, p = 0.095) showed a trend being associated with increased risk but did not reach statistical significance in this study.

Kp10 treatment showed a trend toward preventing this reduction in female neonates, though the difference did not reach statistical significance ( p = 0.0692).

Trends in Mortality In-hospital mortality showed a decreasing trend over 2009–2024 based on meta-regression analysis; however, the reduction did not reach statistical significance (β = -0.012, p = 0.055).

A positive trend was observed for folic acid intake, although it did not reach statistical significance ( p = 0.061).

Although the probiotic group showed a trend towards reduced plasma CRP-levels, this effect did not reach statistical significance.

Additionally, SKCM patients with low GPR37 expression showed a trend toward longer overall survival following immunotherapy, though this difference did not reach statistical significance ( P = .061; hazard ratio [HR] = 1.77, 95% CI 0.92–3.02; Fig. 7 A).

Concentration was inversely related to pollution levels (SMD ‐0.14; 95% CI ‐0.21 to ‐0.06; P < .001), while sperm count showed a trend toward reduction but did not reach statistical significance (SMD ‐0.12; 95% CI ‐0.26 to 0.01; P = .06).

For menstrual pain duration, the intervention group showed a trend toward fewer pain days compared with the control group; however, this difference did not reach statistical significance in adjusted analyses.

In Ad.GFP-infected cells, the mitochondrial fission protein Drp1 showed a trend toward reduced levels; however, this change did not reach statistical significance.

Fecal moisture content showed an increasing trend in the JCJ-HYD, NF-HYD, FNF-HYD, and FNF/2-HYD groups; however, these changes did not reach statistical significance ( Figure 4 H).

In contrast, the Shannon diversity index exhibited a decreasing trend in the F group, although this change did not reach statistical significance ( p > 0.05).

Western blot analysis showed that although the phosphorylation of AMPK (p-AMPK) exhibited an increasing trend in the MG5012- and MG741-treated groups compared to the HFD group, this difference did not reach statistical significance ( Figure 4 F,I).

An increasing trend was observed in the number of junctions and nodes and the total length of the network, although it did not reach statistical significance.

A small trend for the worst OS in patients with CMV+ was observed for the patients of the old cohort treated by NAC, but did not reach statistical significance, probably because of the small number ( n = 71) of patients in this category ( Figure 6 B).

In our study, A549 sEVs showed a trend toward increased fucosylation compared with BEAS-2B sEVs, although this difference did not reach statistical significance.

Although the change over time in the bedinvetmab group did not reach statistical significance (p-value approaching significance), a similar downward trend was observed.

Although this group also exhibited a positive trend towards promoting cell proliferation and migration in the colony formation and Transwell assays, respectively, these effects did not reach statistical significance.

The landmark analysis starting 6 months post-procedure indicated that patients with an increased age gap post-CABG showed a trend towards higher mortality risk compared with those with a decreased age gap, though this did not reach statistical significance (HR 1.51, 95% CI 0.94–2.41; P = 0.09).

Female sex showed a trend toward a lower relapse risk but did not reach statistical significance (HR: 0.63, 95% CI: 0.16–2.52, P = 0.071).

A history of hypertension showed a trend toward a negative association that approached, but did not reach statistical significance (adjusted OR = 0.424, 95% CI: 0.178–1.009; p = 0.052).

QoL outcomes showed a positive trend favoring TCM combination therapy (SMD: 0.82, 95% CI: -0.17 to 1.81), although this did not reach statistical significance.

Β cell mass showed an increasing trend with LNP-induced PD-L1 expression, but did not reach statistical significance ( Figures 4 G and 4H): however, eGLP-LNP+ CD274 -treated islets displayed a decrease in severe insulitis compared to PBS, empty LNP, and unconjugated LNP+ CD274 conditions ( Figure 4 I).

Gender showed a trend toward lower odds of failure among males compared to females (OR 0.65, 95% CI: 0.4–1.2), although this did not reach statistical significance ( P = 0.068).

While the primary analysis for superiority showed a trend toward benefit, it did not reach statistical significance.