“did not reach statistical significance”

64 – 66 One such study showed a trend toward improvement in insulin sensitivity after CPAP therapy using the hyperinsulinemic–euglycemic clamp; however, the degree of improvement did not reach statistical significance. 67 It is possible that the failure to obtain a statistically significant result was because mean nightly usage of CPAP in that study was only 3.6 hours.

Recently, one study found that the presence of NAFLD showed a favorable trend on survival rates in CRC patients, although the data did not reach statistical significance ( P = 0.079), perhaps in part due to the small number of patients (227 patients) and poor statistical power. 20 Therefore, we aimed to design a large and more statistically robust cohort study to investigate the impact of NAFLD on the prognosis of patients with CRC.

MIG level also showed an increasing trend but did not reach statistical significance (486 ± 1401 vs. 649 ± 1147 pg/mL, P = 0.069).

There was also an increasing trend in left ventricular internal diameter during diastole (LVIDd) from 36.2 ± 2.8 mm prior to infarction to 38.7 ± 2.9 mm and 40.9 ± 5.4 mm following infarction and at 8-weeks respectively (Figure 3 b), though this parameter did not reach statistical significance (p = 0.15).

In addition to an increased occurrence of hypertension, patients with the variant allele in IL8 rs1126647A>T showed a trend towards improved PFS/OS (22 vs 14 months for median PFS and 40 vs 25 months for median OS), although the differences between groups did not reach statistical significance.

Although there was a slight trend towards greater microglial activation in the lesioned striatum of PLP-α-syn as compared to control mice, the difference did not reach statistical significance in terms of OD CD11b .

The DTI score, which quantifies the number of VPs per investigated surface area, showed a trend toward higher mean values in the carriers of FLG mutations compared with FLG wild-type subjects at week 0 (427.0 and 336.2, respectively) and after 6 weeks of therapy (296.6 and 224.3, respectively), although the differences did not reach statistical significance (data not shown).

Age only showed borderline significance in women, and diabetes did not reach statistical significance.

Although MoDCs exposed to bLF showed a trend towards a higher accumulation of CCL1 mRNA at both time points assessed (4.6 and 5.3 fold increase at 2 and 4 h post treatment, respectively), the differences did not reach statistical significance ( Figure 2 B). 2.2. bLF-Mediated Up-Modulation of CCL1 Secretion Requires Different Receptors in Mo and MoDCs LF can interact, specifically or by virtue of its highly cationic nature, with a variety of cell determinants with different grade of specificity, including molecules involved in pathogen recognition such as DC-SIGN, CD14, TLR2 and TLR4 [ 4 , 5 , 27 ].

Sensitivity analysis for unobserved confounding The difference-in-difference analysis showed a trend towards more emergency admissions among intervention patients than controls, but the effect size was smaller than in the primary analysis and did not reach statistical significance (difference 0.10 admissions per head, 95% CI −0.06 to 0.26, p=0.220) (see online supplementary table S1 and figures S1 and S2).

Expression of CD32 on CD141 + DCs showed a decreasing trend already after 8 weeks, but this change did not reach statistical significance (p = 0.0651; S3 Fig ).

The corresponding OR of failure of SLNM showed a trend with 3.8, but Chi-Square test did not reach statistical significance in this subset of patients (p = 0.09).

Though there was a positive trend with increasing cell loss and increased respiratory chain deficiency in remaining cells, this did not reach statistical significance (Spearman's rank correlation coefficient).

Specifically, although AstroEGFR*1, which reached overexpression levels comparable to those in AstroEGFR*2, showed a trend of extended survival that did not reach statistical significance, AstroEGFR*3, despite much stronger Zfp423 overexpression, displayed a shorter survival.

ADC values of these regions showed a positive trend, but did not reach statistical significance.

Notably, Pdgfd -/- mice showed a trend towards smaller islets, although the differences did not reach statistical significance (p = 0.21) due to large standard deviations ( Fig 7J ).

Our results showed a trend towards higher levels of N-glycosylation and trastuzumab resistance, but this did not reach statistical significance ( P = 0.081) ( Fig. 4c ).

Although MER pre-treatment also showed a trend towards decreased activation of all caspases, this did not reach statistical significance compared to the DAU group.

Other aspects measured also showed a trend towards improvement in the PACE group, although this did not reach statistical significance.

At 3 weeks post-irradiation, there was an overall trend towards a lower hemoglobin concentration, lower MCV, lower platelet count, and lower WBC count in the MIWI2 −/− mice ( Figure 4 ), but the differences did not reach statistical significance.

Ail-E43D showed a trend toward reduced binding but did not reach statistical significance (p = 0.08).

Though difference between DML, DMH and DMN groups did not reach statistical significance, nesfatin-1 injected mice showed a trend toward a dose-related decrease in plasma FFA levels (DML 2.57±0.34 mmol/L vs.

Although we observed a strong trend of inhibition, the differences did not reach statistical significance because of variations between experiments.

When we analyzed our results according the number of follicles, we observed a positive trend toward stimulation with r-FSH + r-LH, although these differences did not reach statistical significance.

While xanomeline showed a trend toward improving cognitive function in these patients, this effect did not reach statistical significance.