Barely Significant
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“did not reach statistical significance”

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Thereafter, the plasma levels of mtDNA in the patient group continued to increase compared with those of the control group (t 72 ), but did not reach statistical significance (controls: 65 (28–119) copies/μL; patients: 281 (110–805) at t 0 , 403 (168–1937) at t 24 and 467 (188–952) copies/μL at t 72 ; controls vs. patients: p = 0.02 at t 0 , p = 0.03 at t 24 and p = 0.44 at t 72 ; Figure 1 B).
This outcome, whose individual components did not reach statistical significance, occurred in 35.5% of patients on treatment vs. 38.5% in the placebo group [relative risk (RR), 0.90; 95% confidence interval (CI), 0.82–0.98; P = 0.02]; 16.4% of patients on treatment and 17.5% of patients in the placebo arm died of cardiovascular causes (RR, 0.93; 95% CI, 0.81 to 1.06); 27.4% of patients on treatment and 29.6% in the placebo group were hospitalized for HF (RR, 0.90; 95% CI, 0.81–1.00).
Heart failure therapy: the fifth card.
Eur Heart J Suppl · 2023 · PMC10120986
AdAg85A vaccine i.n and i.m boosting to BCG-immunized animals further significantly enhanced it to 467 and 412 days, respectively although the differences between BCG and BCG/Ad i.m groups did not reach statistical significance ( Fig. 5 ; p = 0.02 BCG/Ad i.n compared to BCG alone; p = 0.12 BCG/Ad i.m compared to BCG alone).
However, the associations for the vmPFC and left anterior insula did not reach statistical significance (pairwise correlations: left striatum, r = − 0.36, p = 0.02; right striatum, r = − 0.35, p = 0.03; left anterior insula, r = − 0.19, p = 0.23; right anterior insula, r = − 0.35, p = 0.02; vmPFC, r = − 0.22, p = 0.12).
The difference between IOP of injected eyes and their contralateral controls averaged over the course of the experiment was an increase of 3.8 +/− 2.81 mm Hg for vehicle-treated and 5.5 +/− 4.21 mm Hg for telmisartan-treated mice (mean +/− SD), but this difference did not reach statistical significance (except at day 14, P = 0.02, Student's t -test).
1 A and graphical abstract), which did not reach statistical significance, but a 19% reduction (RR 0.81; 95% CI: 0.69 – 0.95, p = 0.02) when the analysis was restricted to 14 days from randomisation (5/11 trials, 1329 patients) ( Fig. 1 B).
The analysis revealed significantly elevated levels of IL-6, IL-8, and IL-10 in the infection group, while IL-17A did not reach statistical significance as depicted in the heatmap (21.26 pg/ml vs. 7.63 pg/ml, p = 0.0210; 20.38 pg/ml vs. 13.02 pg/ml, p = 0.0050; 10.99 pg/ml vs. 5.63 pg/ml, p < 0.001, respectively, Figure 5 ).
46 Although the pooled effect size (Hedges’ g=0.07, 95% confidence interval −0.08 to 0.22, P=0.360) was small and did not reach statistical significance, there was notable variation across intervention types—most prominently in dialectical therapy (g=0.361, P=0.021).