“highly significant”

At the provincial level, the analysis reveals a highly significant difference in case distribution across months ( χ 2 = 169.82, df = 11, p -value < 2.2e-16).

High phenotypic correlations were observed for both females ( r = 0.98) and males ( r = 0.95), with highly significant p values ( p < 2.2 × 10 −16 ).

Comparison using a paired t-test for R s from the predictive model and their corresponding permutated variant indicated a highly significant difference between both model types ( p -value < 2.2 × 10 −16 across cases), indicating that these model predictions are extremely unlikely to be due to chance.

There was a highly significant effect of orchard on epiphyte species richness per tree ( F 4,607 = 358.17, p < 2.2 × 10 −16 ) and a highly significant effect of cultivar nested within orchard ( F 5,607 = 20.92, p < 2.2 × 10 −16 ; Appendix S2).

We observed a highly significant rate of concordance and overlap between cerebellar expression profiles of Atxn1 −/− and Atxn1 154Q /+ mice (z = 11.9485, P -value<2.2e-16, Kendall-τ test).

Although correlation is less than observed for the H3K4me3 replicates, many H3K4me3-positive loci are bound by TBP and the correlation is highly significant (r = 0.40, p<2.2 * 10 -16 ).

Thus, because there are three possible replacement nucleotides per site, WC sites are ∼66% saturated and nWC sites are ∼90% saturated, and this difference is highly significant ( p <2.20×10 −16 , Binomial test; see Materials and Methods for details).

Comparing the probeset response slopes predicted by our model with the slopes obtained from the Affymetrix tissue panel data, we detected a highly significant correlation both in mouse and human (Pearson correlation coefficient in mouse 0.528, P << 2.2 × 10 −16 , and in human 0.468, P << 2.2 × 10 −16 ).

Despite these differences, δ age and δ PD showed a highly significant positive correlation (r = 0.71, p < 2.2 × 10 −16 , Pearson) ( Figure 4 C), suggesting that the process of decoupling is qualitatively similar and has a comparable genome-wide distribution in HA and PD, although it is more pronounced in the latter.

Finally, we observed a highly significant increase (one-sided Student’s t -test, p = 2.2 × 10 −16 ) in average epistasis values in the winning CR genotypes compared with the overall population, indicating that positive epistasis plays an important role in determining the fittest genotypes in this selection (Fig. 5b ).

The overlap was highly significant (Fisher’s exact test P value <2.2 × 10 −16 ).

A Wilcoxon signed rank test, which compared the ranks based on the two methods, was highly significant ( P < 2.2 × 10 −16 ).

We observed a highly significant gain of methylation with age at the locus in the LBC cohort, validating our approach (Fig. 1 a, T-test, p < 2.2 × 10 −16 ).

Despite the difference in patient population and array platform, the correlation between PLK1 mRNA expression and DNA damage accumulation signature was highly significant in both datasets ( p < 2.2×10 −16 for both the TCGA and REMBRANDT dataset).

Withdrawal of glutamine reduced global translation in both conditions, but there was a highly significant increase in translation driven by MYC compared to that seen in cells transduced with the pM6P vector in the absence of glutamine ( P value = 2.2 × 10 −16 ).

The results indicated highly significant Pearson correlation coefficients of −0.82, −0.68, −0.78, and − 0.71, respectively, with P -values < 2.2e-16 ( Fig. 3B-E ).

Indeed, this overestimation was highly significant (1-tailed t- test, t = 9.66, df = 557.16, p < 2.2 –16 ).

Out of 387 proteins associated with gestational age in human amniotic fluid, 225 (58%) were also associated with gestational age in rhesus and the correlation of effect sizes between the two species in the 225 overlapping false discovery rate (FDR) significant proteins was highly significant (R = 0.75; p < 2.2e–16; Fig. 4 ).

The median Laa value for SCT strain-specific genes (183 aa) was smaller than that for the other genes (280 aa), the difference being highly significant according to a Wilcoxon rank sum test ( p -value < 2.2e-16).

The enrichment for tryptophan-depletion-induced W>F peptides (44 versus 4) is highly significant, considering the globally reduced protein expression ( P < 2.2 × 10 −16 ; Fig. 2b, d ).

The final model was highly significant ( p = 2.2e−16), and for all three cancer types IRF1 was identified as a significant explanatory variable for CD274 expression (Table 1 , left 3 columns).

We observed a highly significant difference in the mean correlation values ( P -value < 2.2e-16, lower-tailed Wilcoxon rank sum test), with a median correlation value of -0.15 for the differentially methylated promoters detected by MethylDriver, more than twice as strong as the average association for all promoters ( Supplementary Figure S4 ).

For both the OE and VNO, the correlation values were highly significant ( P < 2.20 × 10 −16 ), and the correlation coefficients between samples from the same subspecies were higher than those found between samples from different subspecies ( Supplementary Table S5 ).

Actually, there was a highly significant positive correlation between the number of FGs and KOs ( R = 0.71, p < 2.2e −16 ) (Supplementary Fig. 8 ).

The histogram of the distribution of the uncorrected p -values suggested that there was a highly significant excess of low p -values ( p -value < 2.2 × 10 − 16 ; Kolmogorov–Smirnov test; Fig. 2A ).