“highly significant”

The polarity score analysis of all expressed ORFs revealed a small but highly significant shift of ribosomes toward the 5′ end of ORFs when RPLP1/2 were depleted (mean of the differences = 0.013, P = 2.2 × 10 −16 ) ( Supplementary Figure S12A ).

A Cochran–Armitage test for trend confirmed a highly significant positive association between engagement level and success rate (χ 2 = 85.34, df = 1, p < 2.2 × 10 −16 ) ( Figure 3 ). 3.4.

Indeed, by calculating a retention index for each cell type, defined as the Pearson correlation between the two matrices, we observed highly significant retention of pairwise distances for each cell type ( P < 2.2 × 10 −16 ; Extended Data Fig. 10e ).

This reduction was highly significant with a p -value < 2.2 × 10 −16 ( Figure 2 ).

ponticus worker (average of 0.00186, range from 0.0002 to 0.0024) versus all other individuals which have very close to zero γ values (average of 1.86 × 10 −6 , range from 6.598 × 10 −7 to 6.461 × 10 −6 ), with a highly significant difference (two-sided Wilcoxon rank-sum test, P < 2.2 × 10 −16 ).

In addition, CREB1 is the top upstream regulator of the 465 overlapping differentially expressed genes (see previous texts) and there is a highly significant, negative correlation ( r = − 0.91, p value = 2.2E−16) between the fold changes for these genes—including the 58 direct CREB1 target genes—in the two comparisons (Supplementary Fig. 3 ).

Supporting this hypothesis, a comparison of the mean coverage of the nuwt regions to that of the non-nuwt regions showed a small but highly significant difference between them (Wilcoxon rank sum test with continuity correction, p < 2.2×10 -16 for all 13 samples).

The overlap is very highly significant (Fisher’s Exact Test: Odds Ratio: 9.38; p-value < 2.2e-16).

A focused analysis of the TCGA-STAD cohort confirmed a highly significant and robust positive correlation between SOX9 and TRAIP mRNA levels (Fig. 2 B, right panel, R = 0.427, p < 2.2e-16).

In contrast, the overall density distribution of 496 protein kinases in the siRNA screen showed a small but highly significant shift ( p < 2.2 × 10 −16 ) towards synthetic lethality with the peak of the density distribution at 0.95 (Fig. 1 c).

The correlation between ω A MK and DoS was strong and highly significant (ρ = 0.964, P -value < 2.2E-16, n = 10,631, supplementary fig.

Wilcoxon rank sum test with continuity correction revealed highly significant changes for old versus young cortex and hippocampus circRNA TPM values ( P < 2.2 E-16) ( Fig. 2d ).

All correlations are statistically highly significant with a p -value < 2.2e-16.

The overall distribution of average within-pair DNA methylation differences showed a highly significant skew to the right in ASD-discordant twins ( P <2.2e−16, Kolmogorov–Smirnov test), with a higher number of CpG sites demonstrating a larger average difference in DNA methylation.

A Wilcoxon paired test showed that these results are highly significant (both P < 2.2 × 10 −16 ).

These tests were all found to be statistically highly significant, with p < 2.2 × 10 −16 .

We found a highly significant enrichment (Fig. 5 ; P < 2.2e-16) of small GWA P values for LD blocks with a sQTL in the German DCM GWAS (909 cases versus 2120 controls), which was subsequently replicated ( P < 2.2e-16) in the international DCM GWAS (1179 cases versus 1108 controls).

The high proportion of variation among environmental means in Figure 3 is supported by highly significant (p< 2.2e-16) differences among the mean effect of each environment.

The lack of parents’ gender information made the genotype combinations of simulated offspring more complex and the PMS more difficult to find, but regardless of gender, the association between PIC and PE was very strong and both were inversely related to PDI ( Table 2 ), with the correlations between the three being highly significant ( p < 2.2 × 10 −16 ).

At the nucleotide level, the nonrandom distribution among these genomic categories is highly significant ( P < 2.2 × 10 − 16 in a χ 2 test for independence).

These differences are highly significant (X 2 test p-value < 2.2e-16).

This difference is highly significant ( P = 2.21 × 10 −16 ), considering that the mean ARE score for human mRNA transcriptome is 3.8 ( Spasic et al. 2012 ).

In this study, highly significant Pearson’s correlations ( p -value = 2.22 × 10 −16 ) among the mRNA expression of these genes were obtained (r ELOVL5-ELOVL6 = 0.90; r ELOVL5-SCD = 0.84; r ELOVL6-SCD = 0.86), supporting the involvement of common elements regulating their mRNA expression.

Notably, the NecropImmScore strongly correlated with immunophenotype score (IPS), with high-score tumors exhibiting significantly higher IPS across all combinations of CTLA-4 and PD-1/PD-L1 status (all p -values highly significant, e.g., p < 2.22e-16, F i g. 6 F–I), indicating enhanced potential response to immune checkpoint blockade.

RNA-seq showed highly significant overlap in gene expression between acute degradation of RAD21-TEV and genetic cohesin depletion in Rad21 lox/lox Nex Cre neurons (p<2.22e-16, odds ratio = 8.24 for all deregulated genes, odds ratio = 23.81 for downregulated genes; Figure 4a ).