“highly significant”

This finding of 50% sensitivity (considering only the peaks that strictly overlap a site) is highly significant (Fisher’s exact test; P < 2.2 e –16) and is a strong indication of the quality of the results, all the more so as the literature derived studies were performed in a variety of species and cell types.

This correlation is also highly significant when averaging polymorphism and divergence within 10-bp adjacent windows ( ρ = 0.50; P < 2.2 × 10 −16 ; fig. 1 ).

Consistent with previous research [4] , a highly significant correlation occurred between the average DDE score of each bin and the enrichment fold of hits for known DDIs ( R 2 = 0.75, P = 2.2E − 16; Fig. 3 B), indicating a high likelihood that a drug will successfully treat a disease if the drug is capable of strongly perturbing the local module of master genes in the interactome.

The lack of parents’ gender information made the genotype combinations of simulated offspring more complex and the PMS more difficult to find, but regardless of gender, the association between PIC and PE was very strong and both were inversely related to PDI ( Table 2 ), with the correlations between the three being highly significant ( p < 2.2 × 10 −16 ).

A total of 190,678 gene pairs had at least one TSG, and the difference in p -values between pairs with TSGs and with no TSGs was highly significant ( Figure 3 , Wilcox rank-sum test p -value < 2.2 × 10 –16 ).

The degree of compartmental conservation is highly significant ( P < 2.2e-16), as ~80% of the genome shows consistent compartmental labeling in at least 16 samples and ~40% is invariant in all 21 samples, in contrast to 7% and 0% to be expected by chance, respectively (Supplementary information, Fig.

The high proportion of variation among environmental means in Figure 3 is supported by highly significant (p< 2.2e-16) differences among the mean effect of each environment.

Conversely, IL-6 exhibited highly significant positive correlations with the other 11 states, including EMT ( P < 2.2 × 10 − 16 ), inflammation ( P < 2.2 × 10 − 16 ), invasion ( P < 2.2 × 10 − 16 ) and metastasis ( P < 2.2 × 10 − 16 ).

Similarly, the prevalence of typhoid was notably elevated in Bumbu (91.3%) compared to Bandal (77.4%), with a highly significant X 2 result ( p < 2.2 × 10 −16 ).

Wilcoxon rank sum test with continuity correction revealed highly significant changes for old versus young cortex and hippocampus circRNA TPM values ( P < 2.2 E-16) ( Fig. 2d ).

The difference between the nuclear area of cells from infected and uninfected plants was highly significant (based on the Brown–Mood median test, p = 2.2e-16), and the nuclear area of cells from P. brassicae -infected plants was 2.8 times bigger based on the median size.

In contrast, the overall density distribution of 496 protein kinases in the siRNA screen showed a small but highly significant shift ( p < 2.2 × 10 −16 ) towards synthetic lethality with the peak of the density distribution at 0.95 (Fig. 1 c).

Before this correction, this correlation was strong and highly significant for the 800 μM HFF-TerT sample (Figure 6B , Spearman's ρ = 0.29, P < 2.2 × 10 −16 , asymptotic t test).

Strikingly, as in human cells, we found a highly significant correlation between 8-oxodG and γH2AX signals within the mouse genes (Pearson correlation test, r = 0.9; P < 2.2e–16) (Figure 4F ).

For each month, the differences between soil and soil + root for COS and CO 2 were highly significant (Kruskal-Wallis rank sum test – p < 2.2e −16 ), with higher CO 2 and lower COS emissions in the soil + root chambers (except for February) (Fig. 3 ).

2008 ) of LMNA-associated genes identified by ChIP is highly significant ( P = 2.2 × 10 −16 , Pearson's χ 2 test).

However, the correlation for the estimated allele frequency differences (|AFD|) between humic and clear‐water lakes for both datasets was weaker ( r = 0.27), although highly significant ( p < 2.2 −16 ). 3.2 Genetic Diversity, Differentiation and Population Structure The evaluation of genetic diversity in the pool‐seq dataset revealed higher levels of genetic diversity in clear‐water lake populations than in humic lake populations (Table S2 ).

This difference was highly significant ( P < 2.2 × 10 −16 ).

Interestingly, pairwise comparisons of the data from each analysis yielded highly significant positive correlations (Pearson’s test, P < 2.2 × 10 −16 ) ( Figure 3 ; Supplementary Table 3 , available online).

A Chi-square test comparing the observed and expected frequencies of different types of AA combinations gave a highly significant result for data pooled across phyla (X 2 = 255.35, df = 2, P < 2.2×10 −16 , Table 1 ).

Based on the comparison of intact to degraded cartilage, the log-fold-changes in RNA expression and the differences in mean promoter region methylation values demonstrated a small but highly significant correlation (Pearson’s r = −0.08, p < 2.2 × 10 −16 , Fig. 2b , Supplementary Table S7 ).

This difference is highly significant ( P = 2.21 × 10 −16 ), considering that the mean ARE score for human mRNA transcriptome is 3.8 ( Spasic et al. 2012 ).

The spatial autoregressive parameter had a positive value and was highly significant ( p < 2.22 × 10 −16 ), indicating that endemism in a given area tends to increase with increasing endemism in surrounding grid cells (independent of the other parameters in the model).

Pagel’s λ test indicated a very strong and highly significant phylogenetic signal (λ=0.99, P <2.22e-16), indicating that attC abundance is strongly structured by evolutionary history.

Knocking out miR-983 caused a highly significant decrease in sperm length in D. melanogaster ( D. mel KO vs., D. mel WT: 1.724 ± 0.065 mm vs., 1.825 ± 0.047 mm; Wilcoxon rank-sum test, P < 2.22 × 10 −16 ; fig. 5 A ).