“highly significant”

For the TCGA data set, the correlation was decreased somewhat (Pearson r = 0.25 compared to 0.36 for the full data set) but still highly significant ( P = 6 × 10 -5 ), demonstrating that the correlation with age is only partially explained by IDH1 status.

The cross‐tabulation between PAP and hr‐HPV outcome has demonstrated a highly significant association ( p < 0.00006; Table 2 ).

Associations of the TIRAP gene haplotypes with ALI risk We next carried out haplotype analysis on the basis of these two associated SNPs and found that a two-allele model of risk provided the strongest predictor of risk, which was highly significant (P = 0.00006 in ALI group vs control group and P = 0.00003 in ALI group vs sepsis alone group).

All seven SNPs of the CEP68 gene showed linkage disequilibrium (LD), and the haplotype of CEP68_ht4 (T-G-A-A-A-C-G) showed a highly significant association with aspirin intolerance (OR = 2.63; 95% CI = 1.64–4.21; P = 6.0×10 −5 ).

In comparison to the most common haplotype 1112, fasting insulin levels and HOMA-IR values of haplotypes 1221 and 2221 were significantly higher and lower, respectively ( Table 1 ), and the difference between 1221 and 2221 was highly significant ( P = 0.00006).

Our study indicates that ffEVs influenced the expression of various genes related to the MAPK pathway (GO:0032873, GO:1900744) in the Cp COCs group, which was also characterized by a highly significant increase in expansion during IVM ( p = 0.00006).

In addition, a highly significant (p=0.00006) 1.6-fold elevation was seen in lactoylglutathione lyase (glyoxalase I, GLO-1) in Alkbh7 -/- vs.

Similarly, highly significant diabetes cis- and trans-acting eQTL-SNPs were identified ( p < 6.0 × 10 −5 and p < 6.0 × 10 −5 , respectively; Supplementary Spreadsheet 2 doi: 10.17608/k6.auckland.5285041 ).

Further, an alternative χ 2 test comparing the null expectation of no association between head-to-head competitions and ranked attraction index revealed this association was highly significant ( P = 0.00006).

We identified altogether five such positions (with P < 6 × 10 −5 , binomial distribution; i.e., highly significant) all of them occurring in the metazoan 18S rRNAs.

Cited2 −/− embryos showed a modest yet highly significant decrease in levels of Lmo4 mRNA when compared with wild-type littermates (1.35-fold decrease; P = 0.00006, n = 12 Cited2 +/+ vs. n = 12 Cited2 −/− embryos), but Lmo4 −/− embryos did not show any difference in Cited2 levels (n = 12 Lmo4 +/+ vs. n = 12 Lmo4 −/− embryos; Fig. 5 a,b), indicating that Lmo4 is downstream of Cited2 .

Specifically, the differentially expressed genes found between T10 and T20 in the pituitary only included 1 enriched GO term “neurohypophyseal hormone activity”, while the biological process of “response to steroid hormone” was highly significant ( p = 0.00006) before FDR correction but not after (FDR = 0.16181).

In recording events with extra-food added ( N = 23 nests), it increased to 30.02% (95% CI = 18.72–41.32), which resulted in a highly significant effect of food supply in experimental nests (RMA, F = 24.32, df = 1, 22, P = 0.00006).

The increased accuracy of the microbiome classifier was highly significant by bootstrap analysis ( p =6×10 −5 and p =.0001 compared to the clinical/demographic and combined brain classifiers, respectively; there was no significant difference between the clinical/demographic and brain classifiers) (Fig. 2 A).

Predictive value of biomarkers and clinical variables on cumulative ICU survival ICU survival at 28-day was associated with highly significant values of IL-1RA serum levels ( P = 0.00006, HR 1.31, 95% CI 1.15–1.50) and SOFA score ( P = 0.001, HR 1.18, 95% CI 1.07–1.30) in septic patients.

The combined data ( Tables 7 and 8 ) reveal a highly significant association ( P =0.00006) with an OR of 3.06 (95% CI: 1.74–5.3) for patients carrying at least one variant allele (CT or TT) compared with the homozygous wild-type CC genotype, and therefore this increased risk applies to ∼56% (132/236) of breast cancer patients.

Three such modules (red, ivory, and light yellow) showed highly significant correlation with the MeJA treatment (Pearson r = 0.75—0.88; p = 6.04E−05–2.03E−09; Fig. 6 A; Supplementary Table S7 ).

However, after controlling for the single-gene effect, the partial correlation between TCL and cancer risk is still highly significant (Spearman’s ρ = −0.69, P = 6.10 × 10 −5 ; fig.

Deleting or duplicating sleep risk genes is associated with autism risk Pooling the MSSNG and SSC datasets yielded highly significant enrichment of insomnia risk (OR = 1.7, 95% CI = 1.5–2.0, p = 6.1 –05 ) and circadian pathway deletions (OR = 4.0, 95% CI = 3.4–4.6, p = 1.3 –05 ), and circadian duplications (OR = 1.8, 95% CI = 1.5–2.1, p = 4.4 –05 ), in ASD compared to controls (see Fig. 3 and Table S6 ). 95% CI of these ORs obtained by bootstrapping confirmed these results (Table S6 ).

This led the authors to assign scores of very low quality despite highly significant indications of efficacy of LOLA (RR 0.70, 95% CI 0.59, 0.83, Z = 4.01, p < 0.000061).

Highly significant MTAs (P < 0.000061) under heat stress conditions were identified for flag leaf area ( xwmc336 ), spikelet per spike ( xwmc553 ), grains per spike ( cxfa2147 , xwmc418 and xwmc121 ), biomass ( xbarc7 ) and grain yield ( xcfa2147 and xwmc671 ).

The improvement from geno2pheno-C Sanger to geno2pheno-C NGS–Sanger + was highly significant ( p -value = 6.22e – 05), while it was only significant at significance level α = 0.11 or higher for the improvement from geno2pheno-C Sanger + to geno2pheno-C NGS–Sanger + ( p -value = 0.11).

The proportion of direct target genes misregulated in fd-3 seedlings is highly significant according to the one-sided Fisher’s exact test (p = 6.257 × 10 −5 ).

The results obtained show that the differences are highly significant for genes ORF1ab ( p = 6.291 × 10 −5 ) and N ( p = 0.00329), while for gene E differences are only close to significance ( p = 0.0672).

Our analyses show that the linear relationship between the two variables is highly significant (b 1 = 4.65; F (1,10) = 43.2; P = 6.3 × 10 -5 ), with a determination coefficient for b 1 of R 2 = 0.78.