Most of the values were highly significant after correction for multiple tests (a = 0.05, p = .000758) as shown in Table 2 . 3.3 Population structure Factorial correspondence analysis showed the geographical clustering of the 12 sampled meadows (Figure 2 ) into 4 distinct clusters: (NE) north‐eastern Aegean, (N) North Aegean, (NW) north‐western/(CW) central‐western Aegean, and (SE) south‐eastern‐Cyprus.
← all phrases
“highly significant”
Sighted at
p=0.09
In the literature
In relation to the IgM, the highly significant McNemar test p -value = 0.00076 indicates that the FIA and CLIA tests convey different information and are not interchangeable, with a very high significance.
However, when the analyses were restricted to the 115 patients who subsequently received chemotherapy (adjuvant or salvage) using multiple gene sets representing the NF‐κB pathway, we observed a highly significant association ( P = 0.00076) with disease‐specific survival as well as a significant association ( P = 0.017) with overall survival (Fig. 1J,K ).
The difference was found to be highly significant (p = 7.6600e-04), and MiF outperformed the other graph similarity coefficients.
Regarding heat-treated preparations (TH), the Kruskal–Wallis test revealed highly significant differences among bacterial strains for both fungi (M3 M. laxa : χ 2 = 14.3, df = 2, p = 0.000769; VV081 C. fioriniae : χ 2 = 15.4, df = 2, p = 0.000446).
When the comparison was performed within each grade, grades 1 and 2 showed highly significant positive correlations between these losses ( p = 0.00077 and p = 0.0093, respectively), while grade 3 did not show any and grade 4 showed a weak but significant correlation ( p = 0.044) (Fig. 7b and Supplementary Fig. 7 ).
We found a highly significant positive correlation between CGI density and number of chromosome pairs in a genome ( r = 0.88, P = 7.9 × 10 -4 ; Figure 1a ) and a significant correlation between CGI density and number of chromosome arms ( r = 0.62, P = 0.037).
To identify a focused subset of plasticity genes likely to be regulated by LPS (regardless of age or specific brain region) to test in vivo , we investigated a highly significant molecular match between the juvenile plasticity signature and an adult brain-derived LPS transcriptome ( GSE3253 ; rank #14, p = 7.9 × 10 −4 e ; empirical p value calculated using molecular match algorithm; Fig. 3a ; Table 3 ).
However, gamma coherence showed highly significant increases during choice compared to must-touch between mPFC and vCA1 ( Figures 1 G and S3 B; mPFC-vCA1 t(3) = 13.760, p = 0.0008), similar to changes reported from T-maze DNMTS tasks. 18 , 19 In addition we found marginal increases in gamma coherence between nRE and vCA1 ( Figure 1 G; nRE-vCA1 t(2) = 3.272, p = 0.082).
The protection was highly significant, with p = 0.0008 for both treatment groups compared with the controls.
These differences were found to be highly significant ( p = 0.0008) with a Fisher’s Exact test.
Thus, the highly significant ACC time course correlation with LAPC (ACC↔LAPC, Z = 0.2803; P = 0.0008*) makes LAPC’s lack of a correlation with RAPC all the more surprising (RAPC↔LAPC, Z = 0.0109; P = 0.84).
Wilcoxon rank sum test revealed a highly significant shift towards trajectory-reliance from session 1 (median = 0.0076) to session 2 (median = 0.1973; w = 116, p -value = 0.0008, r = 0.5128), from session 1 (median = 0.0076) to session 3 (median = 0.2757; w = 46, p -value < 10 −5 , r = 0.6781), from session 1 (median = 0.0076) to session 6 (median = 1.0241; w = 2, p -value < 10 −8 , r = 0.7385), from session 2 (median = 0.1973) to session 6 (median = 1.0241; w = 16, p -value = 0.0001, r = 0.6953) and from session 3 (median = 0.2757) to session 6 (median = 1.0241; w = 20, p -value = 0.0014, r = 0.6534).
3 explains this behaviour of HAM scores [all p values obtained by paired (red) or unpaired (black) Student’s t tests]: in patients, the difference between pre- and post-treatment values is highly significant ( p = 0.0008), while in controls there is practically no effect of treatment ( p = 0.68).
Another clone (5B3, from pool F, Mm8 Chr16: 91155139–91157882), containing an insert located 57 kb downstream of 5A5, similarly induced expression in the trigeminal ganglion ( Figure 2 ), although in this case the penetrance of the phenotype was lower (41%, n = 22), albeit highly significant (p = 8×10 −4 ).
When considered along a composite axis [2PC1–PC2, Figure 2A ], TGFβ treatment induced significant differences [two-way ANOVA, p = 7.5e-10], and the interaction term, which assessed whether the effect of TGFβ was the same in the presence or absence of VPA, was also highly significant [ p = 0.0008] indicating that VPA did indeed alter the response to TGFβ.
This difference was highly significant ( p = 0.0008).
The model was found to be highly significant ( p = 0.0008), with R 2 = 0.9524 and Adj-R 2 = 0.8913, indicating a good fit to the experimental data and good predictive capabilities.
Patients presenting within six hours of symptom onset had markedly better outcomes (42.4% favourable) compared to those arriving later (10.5% favourable), with this association being highly significant (p = 0.0008) (Table 8 ).
The difference between morphotypes was highly significant (t-test, T 10 = −4.78, P = 0.0008).
Nevertheless, ANOVA across the three biomarkers of neural cell development indicated highly significant differences among the three groups ( p < 0.0008) that depended both upon the specific measure and brain region (treatment × measure × region, p < 0.0002).
NU7441 enhanced the cytotoxicity of doxorubicin 2-fold at the LD 50 concentration (doxorubicin alone: LD 50 = 12–13 nM; doxorubicin with 1 μM NU7441 LD 50 = 6 nM), and for both cell lines this effect was highly significant (2-way ANOVA p = 0.0008 for TC-71, p < 0.0001 for VH-64 cells).
While rs2555639 was the only SNP that was significantly associated with risk of colon cancer in each of the discovery and validation sets independently, several additional SNPs had highly significant association with risk when combining data from the discovery and validation samples ( Table 5 ), including rs1365611 (OR = 1.73, 95%CI:1.26–2.37, p = 0.0008), rs6844282 (OR = 1.42, 95%CI:1.10–1.83, p = 0.0078), and rs2332897 (OR = 1.74, 95%CI:1.27–2.38, p = 0.0006).
On multiple logistic regression, notching remained highly significant at p=0.0008, with an odds ratio of 17.43.
The distribution of hypermethylation and hypomethylation loci among comparison pairs was highly significant (χ 2 (2-df) = 14.17, P = 0.0008).