“nominally significant”

Logistic regression analysis under the additive genetic model (Table S2 ) revealed 3 nominally significant SNPs with p < 0.05 ( PLG /rs4252120, KIAA1462 /rs2505083, and SLC22A3-LPAL2-LPA /rs2048327) and 2 SNPs showing a trend for association with p < 0.10 ( SORT1 /rs602633 and SMG6 /rs2281727) ( Table 2 ).

Notably, the SNPs at 11q12.1 also are nominally significant (P<0.05) in the NFD subgroup, which is different from the observation for the SNPs at 6p21.32.

16 , 18 , 88 We observed a further 30 nominally significant associations (p < 0.05), confirming previous MR findings of an increased risk of CAD, within the UK Biobank population ( Figure 3 , Table S16 ).

We had 80% power to detect nominally significant associations (p = 0.05) with SNPs that account for at least 0.8% of a trait's variance (full sample) or at least 1.0% of variance (individuals with MRIs).

Genes were selected for correlation and PCA analysis if they displayed nominally significant changes in the QuantiGene Plex assay (p ≤ 0.05) as well as nominally-significant changes in either human lymphoblasts exposed to ethanol, mouse NS-5 cells exposed to ethanol, or PBLs from binge-drinking adolescent rats.

We find that all 36 were at least nominally significant and 32 codes have a p -value < 0.05 and, after multiple testing correction, 25 of 36 ICD10 codes are significant in both cohorts, thereby indicating the consistency of our findings.

The remaining nominally significant associations (P <0.05) were considered as having weak evidence .

In addition, we identified 61 genes that were nominally significant association ( P < 0.05) with both tau and amyloid deposition including APOE , TOMM40 , and COL5A2 ( P < 0.005) with both tau and amyloid pathologies (Supplementary Fig. 4 and Supplementary Table 13 ).

Overall, we found nominally significant associations ( P -value < 0.05) with exons common to the intermediate and short transcripts (Table 2 ).

There were only a handful of nominally significant associations (i.e., uncorrected p < 0.05; Fig. 1 ; Table 2 ) .

Of the 21 variants, 6 were nominally significant (p < 0.05).

Results nominally significant at two-sided P < 0.05 were cited.

The mediating effects of three body fat indexes ( BMI, WHR and body fat percentage ), which were nominally significant in both models ( P < 0.05), were further evaluated for nature indirect effects ( NIE ) and nature direct effects ( NDE ) on the impact of age on diabetes oncome by VanderWeele's mediation approach 25 , 26 , 27 as follows: M B o d y _ f a t _ i n d e x e s = β 0 + β A g e ⋅ A g e + B ⋅ C o v a r i a

Pathway analysis performed in Metaboanalyst using all nominally significant metabolite changes ( P ≤ 0.05, FDR < 0.2) after loss of frataxin revealed effects on arginine biosynthesis, alanine metabolism, TCA cycle, taurine metabolism, and glutathione metabolism with many of the changes common among the heart, cerebellum, and mitochondria ( Supplemental Table 2A ).

For the loci that explained a significant proportion (nominally significant SNP heritability estimate, P < 0.05) of the total SNP heritability of F gRI-D and white matter tracts, we proceeded to perform bivariate local genetic correlation.

In the combined three cohorts, four single nucleotide polymorphisms in or near FTO, GNPDA2, NEGR1, and SEC16B loci showed nominally significant interactions with total fried food consumption on BMI (all P<0.05 for interaction).

The associations remained nominally significant ( P <0.05) following an adjustment for intakes of other foods ( Table 2 ).

While only nominally significant at p < 0.05, there was preliminary indication of differential methylation of genes involved in GTPase activity (GO ID:0090630) and cell-cell adhesion (GO ID:0098609) (See Supplementary material).

We combined all nominally significant (edgeR p < 0.05) DET from both brain regions into a single list.

Five SNPs showed nominally significant p-value (p-value<0.05), indicating that part of candidate SNPs of refractive error are associated with its two major intermediate traits.

To test for parallel patterns of gene expression, we first filtered potential candidate genes based on a nominally significant slope (either positive or negative at P < 0.05) between ornament size and gene expression (normalized transcript counts; Dataset S6 ).

The correction was nominally significant ( p < 0.05) for the remaining three structures: pars triangularis (PTR, r = 0.29), rostral middle frontal gyrus (RMFG, r = 0.31), and transverse temporal gyrus (TTG, r = 0.27).

We identified a fully connected cluster of diseases where all pairwise genetic correlations were nominally significant (p ≤ 0.05).

For BMI, after combining results from these three sample sets, we listed all nominally significant association results with meta-analysis P values < 0.05 in supplementary Table S4 .

Meta-analysis suggested that genetically proxied statin use was negatively associated with the order Actinomycetales, the family Actinomycetaceae, and the genera Actinomyces , Ruminococcus gnavus group , Eisenbergiella , and Erysipelatoclostridium at a nominally significant level ( P < 0.05) ( Figure 3 A ; Table S4 ).