“nominally significant”

1 Of the 208 unique genes associated with muscle strength in the meta-analysis all were significant in FHS alone (nominal P < 0.05), and 79 (38%) were also “independently” associated with muscle strength in the Illumina meta-analysis (nominally significant, P < 0.05).

The 36 nominally significant miRNAs ( p < 0.05) identified in the PDN/PDD comparison from LIMMA were used to classify disease state (See Figure 2B ), though with more limited accuracy than the PD-control model (absolute error rate = 13.8%, sensitivity = 81.2%, specificity = 88.9%).

In a second approach, we performed an MR using SNPs that were selected as IVs in EUR and that were nominally significant ( P < 0.05) in non-EUR.

In addition, we identified 61 genes that were nominally significant association ( P < 0.05) with both tau and amyloid deposition including APOE , TOMM40 , and COL5A2 ( P < 0.005) with both tau and amyloid pathologies (Supplementary Fig. 4 and Supplementary Table 13 ).

Putative biological impact of differentially methylated genes The DMPs above the inflection point ( p < 0.002; n = 82; Table S 2 ) and nominally significant DMPs ( p < 0.05; n = 1957) were physically and functionally mapped to 66 and 1260 genes, respectively.

The mediating effects of three body fat indexes ( BMI, WHR and body fat percentage ), which were nominally significant in both models ( P < 0.05), were further evaluated for nature indirect effects ( NIE ) and nature direct effects ( NDE ) on the impact of age on diabetes oncome by VanderWeele's mediation approach 25 , 26 , 27 as follows: M B o d y _ f a t _ i n d e x e s = β 0 + β A g e ⋅ A g e + B ⋅ C o v a r i a

We combined all nominally significant (edgeR p < 0.05) DET from both brain regions into a single list.

Five SNPs showed nominally significant p-value (p-value<0.05), indicating that part of candidate SNPs of refractive error are associated with its two major intermediate traits.

To test for parallel patterns of gene expression, we first filtered potential candidate genes based on a nominally significant slope (either positive or negative at P < 0.05) between ornament size and gene expression (normalized transcript counts; Dataset S6 ).

We report nominally significant associations at the P ≤ 0.05 level.

Additionally, we required a relationship to be nominally significant ( P < 0.05) with both measures of the same PUFA (plasma and RBC) and in the case of COVID-19 severity, with different outcome GWAS (study A2, B2, and B1).

The correction was nominally significant ( p < 0.05) for the remaining three structures: pars triangularis (PTR, r = 0.29), rostral middle frontal gyrus (RMFG, r = 0.31), and transverse temporal gyrus (TTG, r = 0.27).

Of the 21 variants, 6 were nominally significant (p < 0.05).

For BMI, after combining results from these three sample sets, we listed all nominally significant association results with meta-analysis P values < 0.05 in supplementary Table S4 .

The associations remained nominally significant ( P <0.05) following an adjustment for intakes of other foods ( Table 2 ).

Among the age-associated sites identified in our study population, 12 sites were nominally significant ( P < 0.05) with Cd exposure group after adjustment ( Table 2 ).

We identified a fully connected cluster of diseases where all pairwise genetic correlations were nominally significant (p ≤ 0.05).

However, the effects reported in Bäumler’s study [ 3 ] were small and nominally significant (two-tailed p < .05) only for bulkiness.

Notably, the SNPs at 11q12.1 also are nominally significant (P<0.05) in the NFD subgroup, which is different from the observation for the SNPs at 6p21.32.

Retesting the nominally significant results ( P < 0.05) of the genetic association analysis with ordered logistic regression using frailty status (robust, pre-frail and frail) phenotype confirmed the previous results.

None of these loci was even nominally significant ( p > 0.05) in the Han Chinese subgroup.

Meta-analysis suggested that genetically proxied statin use was negatively associated with the order Actinomycetales, the family Actinomycetaceae, and the genera Actinomyces , Ruminococcus gnavus group , Eisenbergiella , and Erysipelatoclostridium at a nominally significant level ( P < 0.05) ( Figure 3 A ; Table S4 ).

A total of 35 proteins exhibited exploratory nominally significant causal associations with UC (IVW p < 0.05).

Pathway overrepresentation analyses Significantly enriched gene sets were further interrogated by extracting genes within these gene sets that exhibited nominally significant associations ( P < 0.05) in the TWAS analyses (up to a maximum of 150 genes).

Of note, 8 metabolites such as indole-3-carboxyaldehyde, tyrosine, citrulline, 3-hydroxypyridine, or 4-hydroxybenzaldehyde positively correlated with tibia SOS, although only nominally significant ( P < 0.05, Q < = 1).