“nominally significant”

Although with small effects (absolute delta betas < 5%), two CpGs in KTN1 were nominally significant (cg14002714 and cg21059882; p < 0.05).

The MR-Egger (SIMEX) method yielded nominally significant ( P < 0.05) causal effects ( P = 0.032).

The associations supported by more than 1,000 cases and significant effects at a p -value of <0.001 were graded as “recommended.” Nominally significant associations ( p < 0.05) were considered weak evidence.

Analysis limited to the younger group identified 665 nominally significant ( p < 0.05) autosomal genes, with only three genes achieving FDR significance.

After conducting heritability analysis across 139 immune traits, we identified 10 immune traits with significant heritability (FDR p < 0.05), and 23 other traits with nominally significant heritability (p < 0.05) in at least one ancestry group.

Genes with nominally significant ( P < 0.05) estimates of SNP-heritability (cis- \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$h_g^2$$\end{document} h g 2 ), are then put forward for training predictive models.

Similar patterns of results were observed in the parent-offspring trio analyses (eTable 8 in Supplement 2 [ie, 2 nominally significant associations between maternal allele scores and NDDs]) ( P < .05; M1 and SCQ-RRB at 8 years: β = 1.73E-03, SE = 8.08E-04; and M2 and SCQ-SCI at 8 years: β = 3.31E-03, SE = 1.46E-03), and there was evidence for association between offspring scores and NDDs ( P < .05; M1 and SCQ-RRB at 8 years: β = −

Two subtypes showed nominally significant (p < 0.05) heterogeneity over EDs after full adjustment: neural tube defects and specifically spina bifida.

An additional analysis of the current study data suggests that, when compared to placebo with no concomitant use of AHM, tadalafil provides small nominally significant drops ( p ‐value < .05) in BP of less than 1.5 mmHg and often less than 1.0 mmHg.

In our phenome-wide analysis, we identified a total of 179 nominally significant associations ( p < 0.05; Fig. 1 , Supplemental Table 5 ) with respect to TTR Ala81Thr, His90Asn, and Val122Ile mutations (60, 54, and 65 associations, respectively).

Genes with nominally significant differential expression ( p < 0.05) between the chronic and acute time points in untreated or P. gingivalis - or C. pneumoniae -treated ApoE -/- mice are tabulated in Figure 3 .

Out of 27 SNPs, correlation with absolute latitude was nominally significant (p < 0.05) for 13 of them.

Survival Pre-HSCT weight, BMI, fat mass, RAPA-Aerobic activity score, Positive Affect, GCGQ score, and ASAS-Wellness all correlated with longer survival; however, these were nominally significant ( p < 0.05) and did not reach significance at our pre-determined level ( p < 0.01).

Finally, to characterize the functional relevance of genes driving the association between effects of LPS on MR imaging measures and expression of cell-type specific genes, we ran a Gene Ontology analysis using genes that were: (i) nominally significant p < 0.05 (MR imaging measure vs. gene expression correlation), and (ii) within the 10th decile in cell specificity for a given cell type (IT4/5 excitatory, or Parvalbumin inhibitory).

In these analyses, 8 of 28 publicly available GWAS summary statistics displayed nominally significant ( P < .05) genetic correlations with TRS, of which 5 survived multiple testing correction (FDER p < 0.05; Figure 4 ; eTable 4 in Supplement 1 ).

Very little epistasis was apparentin the hotspot regions, with less than 7% of trans methQTL in these hotspots possessing a nominally significant (P<0.05) epistatic interaction, and less than 1%of trans methQTLwith a significant epistatic interaction(see Supplementary Table 3 ).

The associations of 4 cytokines, namely, IL-1ra, beta-nerve growth factor (bNGF), stem cell factor (SCF) and macrophage colony-stimulating factor (MCSF), with sepsis outcome pairs were nominally significant ( P < 0.05) (Figure S1 ).

The cranial base width (14q21.1), intercanthal width (1p13.3) and upper facial depth associations were at least nominally significant (p < 0.05) in both datasets.

In total, 15,803 transcripts, including both coding and non-coding transcripts were measured with sufficient coverage in both samples, of which 503 were found to have nominally significant differential expression (p<0.05), which after correction for multiple hypothesis a total of 35 were considered significantly expressed (p<0.05, Benjamini-Hochberg) ( Sup.

For any nominally significant findings ( P <0.05) in the sex‐specific end points, a post hoc hypothesis test was performed to evaluate whether the MR estimates between the male and female end point were significantly different ( P value <0.05) from each other.

To determine CNV enrichment, we only considered loci that were nominally significant between the comparative groups ( P < 0.05).

The criteria for level of evidence classification criteria convincing evidence (Class I): More than 1,000 cases, significant summary associations ( p < 10 −6 ) per random-effects calculations, no evidence of small-study effects (Egger < 0.1), no evidence of excess of significance bias, prediction intervals not including the null value, largest study nominally significant ( p < 0.05), not large heterogeneity ( I 2 < 50%), and robust results based on sensitivity analysis.

In addition, nominally significant differences (ie, P < 0.05) between groups were obtained in secondary analyses comparing the treatment groups with respect to measures of pain interference with function and sleep using items from the BPI interference question.

Nominally significant positive correlations (p < 0.05) were observed in kidney, liver, lung and muscle (Supplementary Fig. 6D-G).

Using this approach, JoineRML identified 10 proteins with nominally significant association with the disease risk (Wald test p < 0.05), of which two had measurements from at least five individuals in both classes and AUROC >0.75 in at least the two last evaluation points (Figure 4a ).