“nominally significant”

There was a nominally significant association between endothelial cell loss and APOE ε4 homozygous genotype ( b = −9.6 × 10 −2 , SE = 4.3 × 10 −2 , P = 2.7 × 10 −2 ), which remained when restricting to only controls ( b = −9.9 × 10 −2 , SE = 4.7 × 10 −2 , P = 4.3 × 10 −2 ; n = 511), adjusting for baseline covariates.

MR analyses showed a nominally significant causal effect of WHRadjBMI on pancreatic cancer (OR[95%CI] = 1.00095[1.00011–1.0018], P = 0.027) but not for BMI on pancreatic cancer.

PSC In accordance with the cis-pQTL definition, a nominally significant association was observed between genetically predicted C8G (IVW, OR: 0.832, 95% CI 0.707–0.979; P =0.027) and CFHR5 (IVW, OR: 1.193, 95% CI 1.048–1.357; P =0.007) in relation to the risk of PSC ( Fig. 2 ).

Furthermore, primary lung cancer patients demonstrated a nominally significant increased odds of having made a serious smoking quit attempt compared to both MSC-1 and LSC-1 controls, with odds ratios of 1.44 (p = 0.028) and 1.42 (p = 0.026), respectively.

Age and sex adjusted MaAslin model indicated that Fusobacteria was nominally significant ( p = 0.029 ) with beta 0.685 (se 0.33) but multiple testing corrections turned to null ( q = 0.309 ) (Supplementary Table 5 ).

However, MVMR was suggestive of a nominally significant causal association between genetically susceptible CHB and severe COVID-19 (OR = 1.12, 95% CI 1.01–1.23, P = 0.029) (Table 3 ).

Although 2-component systems did not reach the FDR 0.1 threshold in DINE-CD, it was nominally significant at P = .03.

The treatment effect for 360 mg, every 2 weeks vs placebo was nominally significant (−16.3%; nominal P = .03); however, significance could not be claimed because the hierarchical testing sequence was interrupted.

There was a nominally significant excess of heart failure (HR 1.34, 95% CI:1.03 to 1.75, p=0.03) but no associations with other studied cardiac outcomes.

A nominally significant similar relationship was observed for the right amygdala, though this did not survive multiple comparison correction (Figure 4b ; Table 2 ; t = −2.2; p = .03, q = 0.06).

Of the seven individual mutations observed in more than 2% of tumors, we observed nominally significant higher frequency of the E545K hotspot mutation in PIK3CA (13.7% vs. 7.5%, Fisher exact test P value = 0.03) and a nonsignificant trend toward higher frequency of the splice variant in GATA3 (4.8% vs. 1.9%, Fisher exact test P value = 0.07) in H/L compared with TCGA Whites (Supplementary Table S5).

Type 1 diabetes was nominally significant in IVW analysis in relation to POAG ( p = 0.03) but no statistically significant signals were obtained for this trait by the other MR methods used in this study (weighted median p = 0.07, weighted mode p = 0.10, MR Egger p = 0.19).

There was a nominally significant relationship between TL and preeclampsia (PE) in the IVW model (OR: 0.799; 95% CI: 0.651-0.979; P = 0.031).

11 We only found a nominally significant association of rs10191329 with the yearly change rate of the lateral ventricles ( p = 0.032), but not with any of the other 14 investigated metrics, including yearly change rates of the total brain volume ( p = 0.690), thalamus ( p = 0.953), or putamen ( p = 0.613).

When women with early menopause were added, breast cancer risk remained increased and ovarian cancer was also nominally significant (3.38 [1.15, 8.65]; p=0.032).

RGS4 was significantly expressed in the coronary artery tissue according to GTEx data (median transcripts per million =18.23), although rs10799925, an intergenic lead variant, and RGS4 expression showed only nominally significant eQTL association (normalized effect size =−0.150; p =0.032).

Supplementary data thorax-2023-220856supp002.xlsx Causal estimate for seropositive RA on IPF The primary IVW-FE analysis gave a nominally significant result for a protective causal effect of seropositive RA on IPF (OR 0.93; 95% CI 0.87 to 0.99; p=0.032) ( figure 2A and online supplemental table 6A ).

meta-analysis ( 29 ), only ARRDC3 passed a Bonferroni-corrected P value threshold ( P = 0.00035), while WSCD1 was nominally significant ( P = 0.032); one of the Falconnier et al. genes had been filtered out during quality control processing in Carter et al.

GlycanAge was significantly lower in the active group compared to the inactive group (β = -7.437, p.adj = 7.85E-03), and nominally significant and increased in professional athletes compared to the active group (β = 7.546, p = 3.20E-02).

The association with previous VTE for one SD increase in CFHR5 level in VEBIOS Coagulation was still nominally significant when adjusting for C3 levels (OR 1.36 [CI 1.03-1.82], p = 0.032), although weaker compared to adjusting only for age and sex (OR 1.55 [CI 1.2-2.01], p = 8.85E-04, Table 3 and Supplementary data 1 [Tab_8] ).

Moreover, we found nominally significant effects (uncorrected) of PAE for FA in the ICP-R (p = 0.033) and SS-L (p = 0.021).

A nominally significant (p=0.034) improvement was observed in global alpha AEC-c.

SLE status was significantly associated with reduced XCI-skew in 40–49 years (p=9.4×10 −4 ) and 50–59 years (p=9.8×10 −4 ), after Bonferroni correction (alpha=0.0125), and nominally significant in the over 60 years group (p=0.034; online supplemental figure S1 ).

The set of 37 monogenic obesity genes showed a weaker but also nominally significant enrichment (2.05-fold enrichment, P = 0.034).

The sole exception was Bacillus subtilis strain 3610, for which the interaction between time post-infection and maternal condition was weakly nominally significant ( S2 Table ; p = 0.034).