“nominally significant”

Of the seven individual mutations observed in more than 2% of tumors, we observed nominally significant higher frequency of the E545K hotspot mutation in PIK3CA (13.7% vs. 7.5%, Fisher exact test P value = 0.03) and a nonsignificant trend toward higher frequency of the splice variant in GATA3 (4.8% vs. 1.9%, Fisher exact test P value = 0.07) in H/L compared with TCGA Whites (Supplementary Table S5).

When adjusting for clinical risk factors, 6 proteins were significantly associated with either MACE or HHF (FDR-adjusted p -value < 0.05), while for the time to DECLARE’s composite renal outcome, IGFBP6 was nominally significant ( p -value = 0.03; Fig. 4C–E ).

There was a nominally significant relationship between TL and preeclampsia (PE) in the IVW model (OR: 0.799; 95% CI: 0.651-0.979; P = 0.031).

Similarly, leveraging a depression GWAS that includes up to 1,999,601 EUR individuals ( 26 ), depression showed only a nominally significant genetic correlation with GlycA ( r g = 0.138, SE = 0.064, p = .032), with an estimate that was about half of the one observed for PTSD.

meta-analysis ( 29 ), only ARRDC3 passed a Bonferroni-corrected P value threshold ( P = 0.00035), while WSCD1 was nominally significant ( P = 0.032); one of the Falconnier et al. genes had been filtered out during quality control processing in Carter et al.

When women with early menopause were added, breast cancer risk remained increased and ovarian cancer was also nominally significant (3.38 [1.15, 8.65]; p=0.032).

RGS4 was significantly expressed in the coronary artery tissue according to GTEx data (median transcripts per million =18.23), although rs10799925, an intergenic lead variant, and RGS4 expression showed only nominally significant eQTL association (normalized effect size =−0.150; p =0.032).

Supplementary data thorax-2023-220856supp002.xlsx Causal estimate for seropositive RA on IPF The primary IVW-FE analysis gave a nominally significant result for a protective causal effect of seropositive RA on IPF (OR 0.93; 95% CI 0.87 to 0.99; p=0.032) ( figure 2A and online supplemental table 6A ).

11 We only found a nominally significant association of rs10191329 with the yearly change rate of the lateral ventricles ( p = 0.032), but not with any of the other 14 investigated metrics, including yearly change rates of the total brain volume ( p = 0.690), thalamus ( p = 0.953), or putamen ( p = 0.613).

GlycanAge was significantly lower in the active group compared to the inactive group (β = -7.437, p.adj = 7.85E-03), and nominally significant and increased in professional athletes compared to the active group (β = 7.546, p = 3.20E-02).

The association with previous VTE for one SD increase in CFHR5 level in VEBIOS Coagulation was still nominally significant when adjusting for C3 levels (OR 1.36 [CI 1.03-1.82], p = 0.032), although weaker compared to adjusting only for age and sex (OR 1.55 [CI 1.2-2.01], p = 8.85E-04, Table 3 and Supplementary data 1 [Tab_8] ).

Moreover, we found nominally significant effects (uncorrected) of PAE for FA in the ICP-R (p = 0.033) and SS-L (p = 0.021).

A nominally significant (p=0.034) improvement was observed in global alpha AEC-c.

SLE status was significantly associated with reduced XCI-skew in 40–49 years (p=9.4×10 −4 ) and 50–59 years (p=9.8×10 −4 ), after Bonferroni correction (alpha=0.0125), and nominally significant in the over 60 years group (p=0.034; online supplemental figure S1 ).

The sole exception was Bacillus subtilis strain 3610, for which the interaction between time post-infection and maternal condition was weakly nominally significant ( S2 Table ; p = 0.034).

The set of 37 monogenic obesity genes showed a weaker but also nominally significant enrichment (2.05-fold enrichment, P = 0.034).

Cross‐fostering had a nominally significant effect on the DNA methylation pattern for Pde4d (Fline: F 1,37 = 4.81; p = 0.035) but significantly interacted with genetic line (Line × Fline: F 1,37 = 9.22; p = 0.004; Figure 1A ).

At 1000 kHz, aged animals exhibited nominally significantly increased resistance (217.5 ± 20.5 versus 151.6 ± 12.9 ohms; p = 0.035, not FDR significant), while phase angle and reactance did not change as compared to young animals (Fig. 3 J–L).

The difference in the proportions of patients with ≥1 TEAE (10.3%; 95% confidence interval, −0.3% to −21.0%) was nominally significant ( P = .0355).

Furthermore, a positive correlation between the 5-year mean IGF-1 SDS and the duration of GHRT was nominally significant (r = 0.421, p = 0.036).

An initial synthesis of the volume data from the left and right habenula using a paired samples t ‐test also supported this point: no significant interhemispheric differences for either the healthy samples ( t (24) = 1.443, p = .162, Cohen d = 0.289), or the patients with SCZ ( t (4) = −0.550, p = .612, d = −0.246); there appeared to be a nominally significant difference in MDD subgroup ( t (10) = 2.403, p = .037, d = 0.725), but it did not survive correction of multiple testing.

Additional sensitivity analyses showed that the cML-MA-BIC-DP method (OR 0.60, 95% CI 0.53–0.69, p = 3.85 × 10 −11 ) yielded a similar result to IVW and weighted median methods ( Table 5 ), while the association from MR-APSS method was nominally significant (OR 0.20, 95% CI 0.05–0.92, p = 0.038) ( Table 5 ; Supplementary Figure S2 ).

Longitudinal stratification of the CIPN phenotypes to examine links for neuropathy, identified nominally significant protective associations with the GSTM* null allele ( p -value = 0.038, OR = 0.55) and the presence of pain at month 2 of treatment, as well as a risk factor for pain related month 2 of treatment for individuals with the GSTT1* null allele ( p -value = 0.030, OR = 1.64).

When tested individually, both di- and tetranucleotides showed at least nominally significant signals (two-sided z -proportion test P = 0.038 and P = 3.7 × 10 –38 , respectively), but trinucleotides did not ( P = 0.95).

Nominally significant positive associations were observed between the weighted PGS and maternal alcohol consumption at week 30 (ST17; beta = 0.067, se = 0.032, p = 0.039).