“reached borderline significance”

If CSF GDF15 is true biomarker of mitochondrial dysfunction of CNS cells, which our data don’t unequivocally support, then idebenone not only did not inhibit mitochondrial dysfunction in PPMS, but may have even slightly exacerbate it based on increase in GDF15 (and albumin quotient) that reached borderline significance in the idebenone group.

Among participants experiencing retirement transition ( n = 2378), only within-person alcohol-to-pain association from Phases 7 to 9 reached borderline significance (β = 0.07, 95% CI: 0.09–0.14), corresponding to a 19.9% increase in above-moderate-pain likelihood per SD increase ( Supplementary Fig.

Among female patients, the association reached borderline significance (HR = 1.07; 95% CI 0.99–1.19), which is consistent with the findings of previous studies [ 38 ].

Still, the effect of actual distance in our study was increased considerably in the fourth model and almost reached borderline significance.

In the RENEW study, both the conventional full-field VEP (which was the primary endpoint of the study) and the mfVEP latency demonstrated a larger improvement in ON eyes of patients treated with opicinumab compared to placebo ( Cadavid et al., 2017 ; Klistorner et al., 2018 ), although this only reached borderline significance.

Clinical Outcomes According to SHR Tertiles Symptomatic ICH was observed in 5.1% of patients at 24 h post-endovascular treatment, with a higher prevalence in the SHR3 group that reached borderline significance across SHR tertiles ( Table 1 ).

This enrichment reached borderline significance in a replication cohort supporting the association of this new candidate gene to NTD .

Our study confirms the findings in the latter study, as high uPAR expression only for the sub-group of well differentiated tumors was associated negatively with OS in the univariate analysis and reached borderline significance in the multivariate analysis.

Gain of 4p has not been previously described in UM, although it was observed in 7 of 80 TCGA study patients (8.8%) and reached borderline significance ( Supplemental Fig 5 A).

In the present study, the multiple logistic regression reached borderline significance for gender which can be due to the sample size.

In the aspect of efficacy, the difference between the two groups in the proportion of good clinical outcomes after the index IVT ( P = 0.054) and in the baseline NIHSS score of the recurrent stroke ( P = 0.056) reached borderline significance.

Three of these five SNPs had been associated with EA ( miR-423 rs6505162, miR-196a-2 rs11614913, and RAN rs14035), while two reached borderline significance ( XPO5 rs11077 and pri-miR-219-1 rs213210).

Using the dominant genetic model, 4 polymorphisms reached statistical significance and 3 reached borderline significance.

After adjustment for multiple testing, the association of c.−436C>A in the logistic regression analysis remained significant for the additive model of inheritance (p empirical = 0.02) and reached borderline significance for the dominant model (p empirical = 0.05) ( Table 1 ).

LPC reached borderline significance with a p -value of 0.07.

Anxiety and arousal reached borderline significance.

In multivariate analysis, AA remained significantly associated with worse survival when adjusted for tumor stage, and reached borderline significance when adjusted for tumor stage and age (Supplementary Fig. 3 ).

The difference compared to “early injection” and “long seizure duration” reached borderline significance (minor overlap of the 83.4%-CI).

A subgroup analysis of seizure recurrence in patients with a calcified lesion reached borderline significance with a pooled CIR of 1.79 CI: (1.00; 3.20) thus favoring 24 months treatment versus 6 months treatment in this particular subgroup ( Fig 7 ).

Patients who had lobectomy ( P = .05) and an open resection via thoracotomy ( P = .06) were at the highest risk of developing new HH, although the difference only reached borderline significance.

For in-hospital mortality, the interaction with primary diagnosis reached borderline significance ( P for interaction = 0.050).

The difference between the H-Y stages of the groups reached borderline significance (slightly higher in the control group).

In our cohort, past users of indinavir had a higher risk of GFR decline that reached borderline significance (PR = 1.7; 95% CI: 1.0–2.8).

They may also include aspects that reached borderline significance rates (e.g. peritraumatic reactions and adaptation difficulties) to investigate whether these turn out to be risk factors in high-quality longitudinal studies.

The adjusted ORs for average MFV and right-sided MFV attained statistical significance and left-sided MFV reached borderline significance.