Barely Significant
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“showed a trend”

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In the literature

Descriptive subgroup analyses showed a trend towards higher rates of RBC-TI ≥ 1.5 years with luspatercept compared with epoetin alfa across prespecified patient subgroups (Fig. 2 ), including patients with baseline serum erythropoietin ≤ 200 U/L (35.9% vs. 15.3%, odds ratio [OR] 3.10, 95% CI 1.76–5.47), non-mutated SF3B1 (21.5% vs. 13.9%, OR 1.70, 95% CI 0.70–4.15), and RS− status [24.5% vs. 16.0%, OR 1.70, 95% CI 0.63–4.62].
Comparison between response groups showed that most cell types had no statistical significance, although cytotoxic CD56 dim NK cells and Effector CD8 T cells demonstrated a trend toward higher levels in Responders, while Naïve and Central Memory CD4 T cells showed a trend toward higher levels in Non-Responders.
Stratification by age groups (Q1 < 40 years; 40 ≤ Q2 < 59 years; Q3 ≥ 59 years) showed a trend of enhanced potential association between LAP and depression in the elderly population (Q3 group), although the interaction did not reach statistical significance (P for interaction = 0.068).