Barely Significant
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“showed a trend”

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in the low-concentration group was higher than that of the control group ( p < 0.05), while both the medium and high-concentration groups were significantly higher than the control group ( p < 0.05) throughout the exposure period and showed some degree of fluctuation; the MDA content ( Figure 2 F) showed a trend of increasing and then decreasing in all treatment groups, with the low-concentration group reaching a peak at 3 h and being significantly higher than the control group ( p < 0.05), and the medium-concentration group reaching a peak at 6 h and being significantly higher than the control group ( p < 0.05), the high-concentration group peaked at 12 h, and its MDA content from 6 to 48 h was significantly higher than that of the control group ( p < 0.05). 3.3.
When contextualized against the reported minimal clinically important difference (MCID) for pain in TMD (VAS: 0–1.9), 71 , 72 both DNT and ACT achieved clinically meaningful pain relief, meeting the MCID threshold. Disability Index (10 Studies, n=833) For functional improvement measures, ACT showed a trend toward greater improvement than TAT (MD −0.065, 95% CrI: −0.13 to 0.00023), though the confidence interval crossed zero.