(2024), showed a trend toward infusion in preventing hypotension, but these were limited by significant heterogeneity, a lack of subgroup analyses according to infusion type, and the absence of TSA for testing the conclusiveness of the pooled evidence.[ 9 10 ] In the light of such limitations, the degree of certainty regarding the true superiority of infusion or bolus regimens remains undetermined.
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Although our PK-PD analysis showed a trend for an association between C min or AUC and outcomes, further prospective investigations in properly sized cohorts remain warranted to confirm these results.
The aggrecan and collagen 2 of the DHJSD treatment group were significantly better than those of the model group at the same time point, and the in vivo inflammatory factors IL-5, IL-1β, and TNF-α, as well as MMP13 and MMP2, showed a trend contrary to that of the ECM.
Changes in NOR behavior in the aging models Compared to the 6 M group, mice in the 20 M group showed a trend toward reduced frequency and duration of exploring the new and old objects by the nose tip (2 cm away from the object) in traditional behavioral metrics ( Figures 3A , B ), though this was not statistically significant (all q > 0.05 after Benjamini-Hochberg correction).
UGT1A1∗28 homozygous carriers showed a trend toward increased risk of severe hematological toxicity.
Conclusion Although exploratory analysis showed a trend toward improvement within the pregabalin group, there was no significant difference in QoR-15 scores between groups.
Surgery was associated with significantly worse facial function compared to observation (g = −5.17, SE = 2.60, p = 0.047, 95% CI -10.27 to −0.08), while the comparison with radiotherapy showed a trend but did not reach significance (p = 0.061).
While R-TKA showed a trend toward greater functional improvement in joint-specific measures, it did not demonstrate statistical superiority over conventional methods in this cohort. knee arthroplasty koos-jr mcid proms robotic tka pmc-status-qastatus 0 pmc-status-live yes pmc-status-embargo no pmc-status-released yes pmc-pro
Other ins-V1 combinations were not different from the NT-DT1 group; however, they showed a trend to diminish when containing more insulin (Fig. 3 G).
Cases with LOY clones ≥80% (n = 15) showed a trend towards more frequent progression to MN than cases with LOY clones <80% (n = 38), however not reaching statistical significance due to small sample sizes (60% vs. 40%, not significant).
Therapies targeting IL-17 and IL-12/23 inhibitors also showed a trend toward reduced arthritis risk compared with TNF inhibitors, but these associations did not reach statistical significance (IL-17: HR 0.62; 95% CI 0.37 to 1.04; p=0.073; IL-12/23: HR 0.66; 95% CI 0.36 to 1.24; p=0.196).
Similarly, a two-week multimodal prehabilitation program for patients awaiting CABG improved functional capacity and showed a trend toward reduced length of stay, although the study was not powered for this endpoint [ 35 ].
Co-expression of miR-142-3p and ZFP36L2 showed a trend of enhanced repression compared to cells transfected with miR-142-3p and control plasmid for most, but not all, HSUR1 target mRNAs.
It also showed a trend of determining a lower RFS, although did not reach statistical significance.
Regarding hormonal parameters, 17OHP showed a trend toward higher levels in males, while A4 did not differ between sexes ( Supplementary Table 1 ). 3.3.
Preliminary analysis of TCGA data showed a trend toward poorer prognosis with high HNRNPA2B1 expression (Figure 1F ).
Additionally, ethnic minority status and low baseline CD3 + levels showed a trend toward higher ORR in univariate logistic regression analysis, though without statistical significance, warranting further validation through long-term follow-up.
The transcription of IL1B also showed a trend toward increasing after doxorubicin treatment (Fig. 3D ).
Albumin showed a trend toward higher levels in HCC compared with iCCA (AUROC = 0.60, sensitivity = 60%, specificity = 65%); however, this difference did not reach statistical significance ( p = 0.06; Fig. 2 A).
Four participants showed a trend toward reduced Opiate Withdrawal Checklist (OWC) scores over time, suggesting symptomatic improvement, while the remaining six showed no notable change.
Granzyme B expression showed a trend toward increase in the combination group (Figure 3C,D ).
The combined outcomes of the wound‐healing rate showed a trend toward higher rates in polyherbal formulations although statistical significance was not consistently achieved.
37 In this study, CC genotype carriers showed a trend toward increased susceptibility to periodontitis compared to GC or GG carriers across additive and recessive models.
Further, when normalized to the number of neurons responding to the positive control KCl stimulation, a significantly higher percentage of VSN CART responded to 22.2 mmol/L glucose compared with 2.2 mmol/L glucose, while the response to 4.4 mmol/L glucose showed a trend toward being higher than that observed with 2.2 mmol/L glucose ( Figure 8 B).
Furthermore, they showed a trend toward higher PWV.