5A ) and showed a trend toward higher AT8 tau pathology ( Fig. 5B ).
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In the literature
Notably, metformin treatment showed a trend toward increased expression of cell cycle regulators, such as p21 and Cdkn1b (not statistically significant), while significantly reducing the expression of the angiogenesis-related gene Mmp9 and showing decreasing trends in Mmp2 and the inflammation-associated gene Nos2 ( Fig. 4D and E ).
In addition, the difference in change from baseline between the groups (Extended Data Table 1a ) showed a trend toward a reduction in arterial inflammation in the low-dose IL-2 group compared to placebo, but did not reach statistical significance (−0.103, 95% CI −0.22 to 0.02, P = 0.086).
At the subcohort level, pS6RP staining was significantly higher or showed a trend toward being elevated in p21-high samples (Supplementary Fig. 11d–f ).
The results demonstrated that the AB-Flu group significantly improved tumor hypoxia, and ME group also showed a trend toward improving tumor hypoxia.
Women showed a trend of lower success rates, but oncological versus non-oncological disease had no impact on outcomes.
In small sample trials and case series of RA patients with severe periodontitis, some patients showed a trend of accompanying reduction in RA disease activity after receiving such intensified treatment, in addition to the improvement of periodontal parameters ( 83 ).
Aortic dissection showed a trend towards higher mortality during FU (OR 2.60; 95% CI 0.13–19).
LIV delivered by piezoelectric disks showed a trend of accelerating wound closure on day 10 post-injury, as assessed by external measurements, compared to sham controls ( Figure 5 ).
As shown in Figure 7C , treatment of cells with the A 2A R agonist CGS21680 significantly reduced IL-8 release triggered by M5 stimulation, whereas cells treated with BAY606583 showed a trend toward reduced IL-8 levels.
Compared to the Control group, mice in the Antibiotics-only group showed a trend toward increased levels of albumin and MMP9 in the hippocampus, although these changes did not reach statistical significance (Supplementary Fig. 1H ).
It also showed a trend to reduce systemic inflammatory markers, such as TNF-α and IL-1β.
Parkin levels showed a trend toward increased levels in Rot-treated neurons (Figs. 3 Q–R), consistent with the recruitment of the mitophagy machinery.
Frequent lifting of heavy objects showed a trend towards higher odds (aOR = 1.38; 95% CI: 0.96–1.99; p -trend = 0.058).
Interestingly, OCY‐EVs showed a trend of higher particle concentration as determined by NTA compared to MSC‐EVs and OB‐EVs (Figure 4D ).
In the primary model adjusted for age, duration of surgery, and urgency of procedure (elective vs emergency), the SAS showed a trend toward association with major postoperative complications, although this did not reach statistical significance.
The results showed a trend toward better outcomes with particle therapy, but this was based only on a small amount of literature and registry data.
In contrast, our cohort showed a trend toward decreased E. coli and more prominent changes in amino acid and lipid metabolism after just 1 week of KD.
An important finding from this review is that GSTP1 rs1695 consistently showed a trend toward a protective association against Hg retention.
The same study showed a trend towards reduced time in bed, increased subjective total sleep time, and improved sleep efficiency, suggesting a reduction in insomnia severity.
6 H) and showed a trend towards decreased proton leak (Fig. 6 J) compared to the vehicle group.
For rs67941642, cells with the T/T genotype (associated with higher TAF4 expression) showed a trend toward reduced proliferation compared to C/C cells, aligning with the tumor-suppressive role of TAF4 .
Patients treated with RT+PD-1 showed a trend toward improved OS compared with those receiving RT alone.
In the USP cohort, patients showed a trend toward later clinical presentation with a higher frequency of visual deficits, growth deficiency, and larger tumour cyst size on volumetric analysis.
Bone marrow transplantation showed a trend towards better survival at two years [ 9 ].