PECAM-1 showed a trend toward increased expression under reversed low-flow conditions (1.99-fold; 95% CI: 1.2–2.8), although this was not statistically significant.
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Alterations in DNA damage response pathways and apoptosis/immune regulatory mechanisms also showed a trend toward enrichment in SS, with the latter observed only in SS tumors (4% vs. 0%), albeit at low frequency.
Although combination showed a trend of relative better efficacy, we did not detect a significant difference in reducing PNF volume percentage change compared to single-reagent PD0325901 or CB-5083 treatment ( Figure 6 A).
With respect to DFS, the later cohort showed a trend toward improvement, although the difference was not statistically significant (log-rank p = 0.176).
Conversely, everolimus and TMZ significantly reduced uptake, and cisplatin showed a trend towards decreased uptake ( Figure 3 ). 4.
Inflammatory cytokines Ifn-γ , Tnf-α , and Il1-β showed a trend toward higher levels in Camp −/− mice compared with both Camp + / + and control groups ( Fig. 2B ).
The antioxidant activity assessed by the ABTS assay showed a trend consistent with the DPPH result, with the highest Trolox equivalent antioxidant capacity observed on day 7.
Both development time and peak time showed a trend of initial increase followed by a decrease, reaching their maximum values at 2%.
Serum creatinine levels also showed a trend toward partial attenuation following omega-3 FA treatment.
The POD activity of wheat in all groups showed a trend of initial increase followed by a decrease, with the peak value appearing on days 2–4 of storage ( Figure 5 H).
Intermediate leaves showed a trend toward increased CAT activity, not reaching statistical significance, along with minimal damage, suggesting effective detoxification, whereas adult leaves accumulated higher levels of Fe, Ni, and Pb, but displayed moderate stress responses.
While cisplatin reduced SOD and TAS levels, NAS treatment showed a trend toward biochemical recovery without reaching statistical significance in oxidative markers.
Meanwhile, the expression of SOCS3 showed a trend of feedback elevation in the high-activity subgroup.
The results showed a trend toward partial recovery of associative learning ability following gene therapy, though it did not reach statistical significance, likely due to inter‐animal variability and a limited sample size compared to rodent behavioral studies (Figure S10 , Supporting Information).
While some studies did not reach statistical significance, all showed a trend towards an increased risk.
Under scotopic conditions, compared with the AAV group, eyes treated with AAV-CoG4 showed a trend toward increases of 130.3 ± 25.6% and 158.2 ± 33.3% in a-wave and b-wave amplitudes, respectively, at the highest flash intensity ( Fig. 7, B, D and E ), suggesting that gene therapy restored normal rod cell sensitivity.
We also note that in PPT1-KO mice, GAP43 hyperpalmitoylation was most pronounced at 1 to 3 months and showed a trend of decrease at 6 months ( Fig. 1, H and I ).
Fear of falling showed a trend toward a 0.7-point reduction in the FES-I.
In the de novo group, TP53 and STK11 mutation statuses were not associated with significant differences in PFS and OS, while KEAP1 mutation showed a trend toward longer OS and PFS, approaching statistical significance (P = 0.06) ( Figs. 4a and 5a ).
Similarly, QoL scores showed a trend toward greater impairment in the MACS group.
Both groups showed a trend that the abnormal rate of nerve action potentials (CMAP/SNAP) was higher than that of the corresponding nerve conduction velocity (MCV/SCV): In the SMN group, the abnormal rate of CMAP (92.3%) was higher than that of MCV (61.5%), and the abnormal rate of SNAP (84.6%) was higher than that of SCV (76.9%).
The cell composition showed a trend change during aging, such as the decrease of neurons and the increase of glial cells (Figure 2G ).
In HFpEF, both excessively low and widened PP showed a trend toward increased risk of cardiac mortality, which echoes previous observations ( 7 , 8 , 22 ).
Conclusion Containment surgery performed during the reossification stage of LCPD was associated with significantly better acetabular morphology and coverage and showed a trend toward improved femoral head sphericity.
Regarding KPS scores, mean age showed a trend toward a negative association with improvement, explaining 26.9% of heterogeneity.