“showed a trend”

In a curtailed randomized trial of 15 colon cancer patients with resected liver metastases, dendritic cell vaccines loaded with autologous tumor lysates showed a trend toward longer disease-free survival compared to observation, despite the small cohort size ( 117 ).

Differential gene expression analysis of islet tissue revealed downregulation of several inflammation-associated genes (Prss3, Mknk1, P2rx1, Rbpjl), while gene set enrichment analysis showed a trend toward suppression of NF-κB signaling and enrichment of PPAR pathways, although statistical significance was attenuated after multiple-testing correction ( Figures 4K,L ).

While TFAM expression showed a trend toward restoration in the AZEV‐treated groups, the difference did not reach statistical significance compared with the UVB‐induced group (Figure 5F ).

Similarly, Edasalonexent, a dual NF‐κB inhibitor, was well tolerated and showed a trend toward slowing disease progression in younger paediatric DMD patients, although it did not meet its primary efficacy endpoints and further development was discontinued [ 115 ].

Quantification of VWF-positive staining in the dermis showed a trend for all groups of increased VWF presence at days 7 and 14 over days 28 and 63 ( Fig.

low ITF involvement ( p = 0.090), though it showed a trend towards poorer outcomes for the high ITF group (Figure 4 ). 5 Discussion Treating locally advanced OSCC remains a serious challenge to the surgeons, primarily due to the significant associated morbidity and mortality and the high cost of treatment [ 6 ].

In terms of PFS, all drugs showed a trend toward superiority over placebo, though to varying degrees.

TEAD3 also showed a trend toward higher expression in metastatic tumors; however, this difference did not reach statistical significance ( Figure S3D ).

Among the four cell lines studied, Panc354 exhibited a statistically significant increase in the proportion of cells in the G2/M phase relative to control, while Panc185, Panc215, and PancA6L showed a trend toward G2/M accumulation that did not reach statistical significance (Figure S1D).

Despite the transplantation of an equivalent number of cells, bioluminescence imaging (BLI) analysis showed a trend toward lower engraftment of E-CMs at later stages (Supplementary Fig. 2e, f).

1 d, h) activities in both sugarcane varieties showed a trend of increasing and then decreasing.

At day 14, the increase in hair follicle numbers showed a trend positively correlated with wound closure in the control, GelMA, and A‐Gel groups, suggesting that the changes in follicle counts in these groups were largely attributable to wound shrinkage.

Both β‐GP and EGCG‐E7 treatments showed a trend toward increased bone mass relative to the db/db group.

While histological sections showed a trend toward preserved tissue architecture in both iPDP‐treated groups (Figure 5a ), quantitative analysis revealed that only the triple‐programmed release group achieved a statistically significant reduction in infarct size relative to MI controls (Figure 5d ).

Genes with shortened 3'UTR generally showed a trend toward increased expression (Figure 6C ).

Patients with PTDM also showed a trend towards more opportunistic infections, although this observation should be interpreted cautiously given the small number of events.

However, another two patterns showed a trend toward normalization over development.

Across pediatric cancers, ACCs expressed the highest levels of ENPP3 ( figure 2F ), and these showed a trend towards worse survival ( figure 2G ).

Under ABA treatment, the expression of CsDRMH3 showed a trend of “first increase and then decrease”, reaching a peak at 12 h (about 4 times of 0 h), and remained higher than the initial level at 48 h.

The results remained largely the same, but showed a trend for positive social support, which was associated with affective symptoms at age 53 and a lower likelihood of ‘consistently moderate/high’ affective symptoms.

KDM6A mRNA levels showed a trend towards a baseline following LPS + GSK-J4 treatment, while KDM6B mRNA levels were significantly reduced compared to LPS treatment ( p < 0.05) (Fig. 4 K and L).

Similarly, the AA genotype showed a trend towards a protective effect, but the association was not statistically significant (OR = 0.439, 95% CI: 0.221–1.099; P = 0.079).

The MDI versus CSII insulin treatment modality showed a trend towards a higher DEPS‐R score risk, although this difference was not statistically significant.

Regular aspirin use showed a trend towards a protective effect in the removal group.

Male participants showed a trend towards an earlier AODS compared with females, although this association did not reach statistical significance.