Excerpts

Nodal involvement showed borderline significance in univariable analysis, with N1 staging having an HR of 1.81 (95% CI, 1.01–3.24; p = 0.047).

In the initial multivariate Cox regression model including all variables significant in univariate analysis, residential area size remained borderline significant ( p = 0.047; HR 1.61, 95% CI: 1.01–2.56; see Table 3 ).

When looking at the Karnofsky performance status of the entire cohort, a weakly significant reduction was observed during the follow-up ( p = 0.047).

Moderately significant differences emerged in the skewness of K based on the CD3/20 prominence, which indicated a decrease in the skewness when CD20 was predominant over CD3 ( p = 0.048); an increase in the energy of K trans was also observed when CD8 was predominant over CD4 ( p = 0.019).

Strong demethylation exhibited a borderline significant correlation with wild-type KRAS ( p = 0.048).

Although age showed a borderline significant association in the multivariate analysis before matching (HR, 1.039; 95% CI, 1.000–1.079; p = 0.048), it was not significant after matching.

Finally, the variation in Clavien–Dindo classification was at the limit of significance ( p = 0.048), with the greatest fluctuations in group I, group II, and group IVa ( Table 1 ).

The symptom “pain during nutrition” was marginally significant compared to PEG placement before the start of therapy ( p = 0.048).

The NSABP B-42 trial, which randomized patients after five years of tamoxifen or AI to another five years of letrozole or placebo, showed a trend toward improved DFS at seven years (84.7% vs. 81.3%, HR 0.85, p = 0.048).

The 5-year overall survival (OS) showed a positive trend in the treated group (PORT group: 67% vs. non-PORT group: 58%, p = 0.048) [ 22 ].

We observed a correlation between FNTB-173 6G > 5G and the histopathological grading at borderline significance ( p = 0.048).

Overall, a modest correlation was found between tumor concentrations and plasma trough levels of pazopanib ( ρ = 0.41), which was borderline significant ( p = 0.049); see Figure 2 .

41.1+ months for C/C genotype; univariate HR 2.18, 95% CI 0.98–4.85), though with borderline significance ( p = 0.049).

The duodenal V33 Gy showed a marginally significant difference ( p -value = 0.049) between ground truth and plan recalculation.

Furthermore, when dividing the age at diagnosis in quartiles (≤43 yrs, 44–54 yrs, 55–63 yrs and ≥64 yrs), the Kaplan-Meier survival curves continued to show a slightly significant difference among the groups ( p = 0.049) ( Figure 2 ).

As seen in Figure 3 A, patients treated with doses between 30 and 40 Gy had a better outcome than non-irradiated patients (HR 0.5, 95% CI 0.25–1.0), with borderline significance ( p = 0.049).

Other borderline significant parameters included the absence ATG in conditioning (HR: 1.52; 95% CI: 1–2.3; p = 0.049), patient CMV seropositive status (HR: 1.41; 95% CI: 1–2; p = 0.041), and HLA-mismatched unrelated donor transplant (HR: 1.68; 95% CI: 1–2.8; p = 0.044) ( Supplementary Tables S5 and S6, Supplementary Figure S9 ).

There was a significant difference in the pre- and postoperative changes in anxiety and borderline significant ( p = 0.0499) changes in pain scores across the three surgical modalities.

In contrast, excessive fluid overload was only associated with significantly decreased pretransplant levels of phosphatidylinositols, and this difference reached only borderline significance ( p = 0.0499, r = 0.6958).

Our analysis reported also a significant trend towards ORR for anti-VEGF combinations (RR 1.46, 95% CI 1.00–2.12; p = 0.05).

The study reported the relative risk of PCa when seropositive for HPV18 as 2.59 (CI 95% = 1.17–5.75) and found the association between HPV18 and PCa to be highly significant ( p < 0.05) [ 81 ].

Healthy nonsmokers exhibited the highest cumulative number of unique reads among all study groups ( Figure 1 D), with a borderline significance ( p = 0.05) compared to healthy smokers.

A comparison between the immunohistochemical factors studied ( Table 3 , χ 2 test confirmed by Fisher’s exact test) showed a positive correlation between CD8 and CD20 cells ( p = 0.01) and a strong trend ( p = 0.05) for positive CD8 and CD163 correlation.

Second, there are genes (seen in green) that show a moderately significant change in expression ( p -value < 0.05) and an absolute value of log 2 FoldChange > 2.

A meta-analysis incorporating these two RCTs demonstrated that LC-CRT significantly improved pCR compared with SC-RT (risk ratio [RR] = 0.15, 95% CI 0.08–0.28; p < 0.00001) and showed a favorable trend toward greater tumor down-staging (RR = 0.61, 95% CI 0.37–1.01; p = 0.05) [ 56 ].