Excerpts

We found 92 (53 increased and 39 decreased) nominally significant DEGs of KRAS mut with a p -value < 0.05, which FREM1 , ERMP1 (up-regulated), and CCL8 (down-regulated) were significant after multiple test corrections (FDR < 0.05).

The PFS results according to high-risk status were borderline significant ( p = 0.05) ( Figure 4 ).

In the evaluation of T2 sequences in IDH positive patients, we found a significant difference between ultra-early and early MRI ( p = 0.008) and a borderline significance between iMRI and early T2 volume ( p = 0.05).

Overall treatment time (OTT) ≥45 days showed a trend for a lower PFS ( p = 0.050) and was significantly associated with lower EFS ( p = 0.030) and histological grade 3 with a lower LC ( p = 0.025).

In the final month, the difference in chemotherapy use is borderline significant (8.5% in males and 6.6% in females; p = 0.05). 3.4.

Lastly, all fixed effects that proved at least borderline significant (p ≤ 0.05) were incorporated into a final LMM for FEV 1s and VC.

When histotype was stratified by tumour stage, Kaplan–Meier analysis revealed a borderline significant difference in survival between patients with homologous and heterologous histotypes (log-rank p = 0.050).

Combined features: The pairing of UCI with EV and GLMB achieved the highest performance overall, with a mean C-index of 0.80 ± 0.11 and demonstrated an extremely significant difference from other methods ( p < 0.05).

Experiencing TRAEs of grade 3 or higher showed a trend towards worsening OS (HR 1.79, 95% CI 1.00–3.21, p = 0.05) and PFS (HR 1.53, 95% CI 0.90–2.59, p = 0.12).

ADC Values and Progression-Free Survival There was a marginally significant association between nADC min and progression free survival (PFS) ( p = 0.05, HR = 0.602, 95%CI = 0.344–1.053).

nucleatum ( p = 0.0026), with a trend towards significance for total cultivable bacterial count ( p = 0.0502).

Additionally, nearly significant differences ( p = 0.0503) were seen in the probability of the age of tumor onset between PALB2 P/LP carriers and patients with normal genotypes.

For example, patients with musculoskeletal irAEs showed a trend towards an improved median PFS of 12 months (95% CI: 5-NA) compared to 5 months (95% CI: 4–8) ( p = 0.0505) in patients with any other irAE and a statistically significant higher PFS compared to patients without irAE (2 months, 95% CI: 1–8) ( p = 0.0068).

The pooled analysis showed a trend toward improved OS with chemo-immunotherapy (pooled HR 0.78, 95% CI 0.61–1.00; p = 0.0505), although the result missed conventional statistical significance and moderate heterogeneity was observed (I 2 = 50.2%) ( Supplementary Table S1 ).

We observed that G9a protein expression levels showed a trend of correlating with cirrhosis ( p = 0.0507), but with no other clinical characteristics in our recruited HCC cohort.

PRS was shorter in the LI group regardless of the recurrence risk, although the p -values were marginally significant (LR, 34.04 ± 25.12 vs. 41.62 ± 21.95, p = 0.051; HR, 26.50 ± 22.48 vs. 32.42 ± 22.64, p = 0.033).

When TMB score was added to the adjusted variables above, the 2tPD-L1 more accurately could predict survival; however, this, too, did not quite reach significance ( p = 0.051) ( Table 4 ). 3.6.

While no statistically significant differences were identified between arms, p -values for time-by-arm interactions approached significance (e.g., p = 0.051). 3.7.

All six lung cancer patients had positive aCL antibodies, and colon cancer patients had a borderline significant association ( p = 0.051).

Although the median time from first-cycle LDT to first-cycle follow-up imaging approached significance ( p = 0.051), and the greatest impact on TTP was HCC imaging delay.

Body weight loss in the C26 hosts ( Figure 1 A) was slightly, but with borderline significance ( p = 0.051), attenuated by exercise ( Figure 1 A,B), while no differences could be observed between sedentary and exercised controls ( Figure 1 A).

Patients with betel quid chewing had a clear trend of adverse prognosis ( p = 0.051). 2.5.

Consistently, the recessive model approached but did not reach significance (OR = 1.606, p = 0.051).

When stratified by cell-of-origin, the association between rs822336 and RFS was borderline significant in ABC-DLBCL (Kaplan–Meier, p = 0.051), whereas no association was observed in the GCB subtype ( p = 0.300).

No prognostic factors were significantly associated with early or late PCS complications, with thrombosis approaching significance ( p = 0.051).