In multivariate analysis, ARBs use was independently associated with decreased in-hospital mortality (OR = 0.65, 95%CI (0.44–0.97), p = 0.04) while ACEis use nearly reached significance (OR = 0.66, 95%CI (0.44–1.00), p = 0.06) ( Figure 2 , Panel B). 3.4.
Moreover, H 2 O 2 generation in DTCs showed a trend toward a correlation with extrathyroidal extension ( p = 0.06) ( Figure 3 ). 3.4.
Factors achieving significance ( p < 0.05) or showing a strong trend ( p < 0.06) incorporated in the survival score.
The recurrence rate observed by response type approached significance ( p = 0.06) ( Table 2 ).
However, by separating the glands into two parts with the top composed of pit and isthmus and the bottom composed of neck and base, we observed an almost significant ( p = 0.06) decrease in nuclear positive cells in the neck and base of H. pylori positive tissue compared to non-infected tissue ( Figure 6 B).
After 4 weeks, X-rays and μCT analyses showed a trend of reduction in osteolytic lesion incidence (chi-square test; p = 0.06) ( Figure 2 b and Supplementary Figure S2a ) along with a reduced osteolytic area ( Figure 2 c,d) in the tibias of N-Cadherin High compared to N-Cadherin Low cell-injected mice.
However, LDH levels showed a trend toward increased risk of transformation (hazard ratio [HR] 2.6; 95% confidence interval [CI], 0.95–7.6; p = 0.06).
A nearly significant lower presence of ctDNA DDR gene mutations was found in non-smokers compared with ever-smokers ( p = 0.06) in the 3-gene subset analysis.
We observed a statistically significant genotype-by-sex interaction for MDM4 rs4245739 ( p = 0.01) and a borderline significant interaction for rs1563828 ( p = 0.06).
In univariable analyses, germline variation in GZMB and PDCD1 showed a trend towards associations with OS according to the dominant model (HR 1.811, 95%CI 0.945–3.364, p = 0.060 and HR 2.027, 95%CI 0.998–4.118, p = 0.051, respectively).
Although only approaching significance, DGE and PPH presented a higher frequency in the PPAP population than in the no-PPAP group ( p = 0.06 and 0.08, respectively).
Furthermore, genetic ancestry, specifically African American ancestry, was also significantly associated with CIPN change from baseline (CE = −7.63, SE = 2.43, and p < 0.002) with an overall significance of p = 0.007, while sex was only borderline significant (CE = 3.29, SE = 1.77, and p = 0.06), Table 2 .
The presence of high endothelial venules, assessed by the MECA-79 antibody, was not associated with any of the factors studied; however, it showed a trend ( p = 0.06, χ 2 = 3.4) for a negative association with p62 nuclear expression.
The association of higher NPAD with postoperative mortality was close to significance at univariate analysis ( p = 0.06) but reached significance ( p = 0.026, OR 3.39 [1.15–9.95]) at multivariate analysis (model including age, side, ppoFEV1, CCI, and NPAD), together with right side of pneumonectomy ( p = 0.0074, OR 4.11 [1.46–11.56]) and CCI >5 ( p = 0.0011, OR 5.56 [1.99–15.54]) ( Table 5 ). 3.
The group with favorable responses showed a strong trend for having been treated with higher cumulative total doses of OT101 than the cumulative doses received by the non-responders ( p -Value = 0.06).
Patients holding an SUV max above this value exhibited a statistical trend toward a longer median PFS (52.0 versus 18.7 months; p = 0.06), Figure 4 .
However, patients with NRAS mutations showed a trend towards prolonged distant metastasis-free survival ( Figure 1 d) (Log-rank test, p = 0.06), but no difference in disease specific survival ( Figure 1 e, p = 0.9), while the two groups ( NRAS mutant vs.
The radiomics feature original_shape_Elongation demonstrated a trend towards significance (HR = 0.45, 95% CI: 0.2–1.03, p = 0.06), potentially indicating a protective effect.
24%), and this difference was marginally significant ( p = 0.06).
A higher expression of the NOTCH pathway signature exhibited a strong trend ( p = 0.06) as a negative predictive factor for responses.
CRT significantly reduced local progression rates (32% versus 46%, p = 0.030) and showed a trend towards better median PFS (9.9 versus 8.4 months, p = 0.060) and longer median time without retreatment (6.1 versus 3.7 months, p = 0.020).
did not find a low PMI to be a statistically significant independent risk factor for OS, although a statistical trend was shown (HR 1.59; 95% CI 0.98–2.59; p = 0.06) [ 35 ].
A trend toward significance was observed for four-year PFS (71%, 58%, and 42% for AA, AG, and GG genotypes, respectively; p = 0.06), while four-year OS differed significantly across the three subgroups (78%, 61%, and 45%, respectively; p = 0.04).
Smoking was 16.5% more frequent in the immunotherapy + cannabis (56.9%) group than the immunotherapy-only group (40.4%), but this difference was not quite significant (χ 2 (1) = 3.512, p = 0.0609, Figure 1 B). 3.2.
Adding the loss of expression of CDX2 to the multivariate model showed it to have a tendency toward significance as increased risk of death (HR = 2.74, 95% CI (0.96–7.84), p = 0.061), and it was statistically significant for risk of death or relapse (HR = 2.77, 95% CI (1.06–7.23), p = 0.037). 3.2.