Excerpts

In contrast, TP53 mutations demonstrated a strong trend toward increased recurrence risk (OR = 7.0, 95% CI 1.16–135.12; p = 0.077), although this did not reach statistical significance ( Figure 4 B).

Knowing that DQI showed a trend toward direct association with SII ( p = 0.077) and was independently related to GI symptom scores, we also tested its potential confounding effect.

Although breast non-pCR as a risk predictor for ypN+ did not reach statistical significance in the multivariate analysis, it still showed a trend of correlation (OR = 13.896; 95% CI, 0.752–256.837; p = 0.077).

There was a marginally significant association between increasing proportion of PD-L1 expression on immune cells and intratumoral CD8+ T cell densities ( p = 0.0773).

A clinically observed association between tumor reduction and the number of injections (on the borderline of significance, p < 0.0775, correlation coefficient = 0.66).

In both cohorts of survival from diagnosis and from symptom onset, the comparison showed a trend favoring biopsy + PET + MRI + EMG-NCS over biopsy + PET + MRI + ultrasound ( p = 0.0779 and p = 0.0962, respectively).

Patients in the pembrolizumab group showed a trend toward longer PFS (median not reached vs. 20.2 months, p = 0.078; see Figure 2 A) and OS (median not reached vs. 26.8 months, p = 0.027; see Figure 2 B) compared to patients in the chemotherapy group.

Liver metastasis approached significance with an HR of 1.89 (95% CI: 0.93–3.87, p = 0.078) [ Table 4 ]. 4.

Univariate Kaplan–Meyer analysis by BTCs subgroups indicated borderline non-significant survival benefits in favor of the observation group in iCCA ( p = 0.0784) and in favor of chemotherapy in eCCA ( p = 0.0781).

The selected treatment schedule (SBRT and 3D-CRT) did not statistically significantly influence the risk of local progression ( Figure 2 C, log-rank test p = 0.55), while GTV and PTV showed a statistical trend (log-rank: GTV > median: p = 0.079; PTV > median p = 0.060).

Baseline ALBI grade 1 patients also showed a trend for less REILD after second SIRT (2/26 = 8%) than ALBI grade 2 or 3 patients (8/28 = 29%, p = 0.079).

HLA-A*24:02 + HLA-A*202:01 − patients showed a strong trend for improved OS than HLA-A*24:02−HLA-A*02:01 + patients (zero vs. seven deaths at four years postdiagnosis, respectively; Gehan-Breslow, p = 0.0794) ( Figure 2 c). 2.3.

They reported a statistical trend ( p = 0.08) towards longer operative times in SGAP cases.

Patients treated with ablative dose are less likely to develop recurrence (adjusted HR 0.54, p = 0.01) and ablative dose showed a trend towards better CR at six months significant (adjusted OR 0.49, p = 0.08).

The D1-TX and pre-TX mean IFV values exhibited a borderline significant difference ( p = 0.08).

Multivariate analysis revealed a statistically significant impact of extrathyroidal extension on RAI-R TC at initial diagnosis ( p = 0.016; hazard ratio (95% confidence interval): 5.2 (1.3–19.8)), while primary tumor size >40 mm was barely not statistically significant ( p = 0.08).

Multivariate survival analysis, limited by small numbers, demonstrated a trend towards significance for cytotoxic chemotherapy as an independent predictor of mortality with a HR 1.93 (95% CI: 0.93–4.00, p = 0.08), while the other individual treatment modalities were not associated with significant differences in COVID-19 mortality ( Table 2 ).

Of the seven selected genes, LAMC2, FPPS, TNC, RAN and STC2 had significantly higher mRNA levels in PDAC samples compared to the normal adjacent pancreatic tissues, and PTX3 showed a trend approaching significance ( p = 0.08), while RNA levels of UCHL-1 were not significantly increased in tumor tissues.

However, when we evaluated MMP-9 and MMP-2 activity in EDL homogenate (EDL muscles have a similar fiber type composition to TA muscles) via gelatin zymography, we found a strong trend for IRI+BGP treatment to increase MMP-9 activity relative to VEH ( p = 0.08; Figure 4 J,N) whilst also significantly reducing MMP-2 activity compared to VEH and IRI treatments ( p < 0.05; Figure 4 K,N).

When the cfDNA characteristics were correlated with the circulating Chromogranin A levels at the time of analysis, a weak but significant correlation was found for cfDNA concentration (r = 0.356; p = 0.011) and Alu hypomethylation (r = 0.310; p = 0.029), and a nonsignificant trend for LINE-1 integrity (r= −0.250; p = 0.08), as analyzed by Spearman correlation analysis.

Mean f values showed a trend towards the difference between the groups ( p = 0.08).

As reported in the REGOMA trial, the subgroup of patients taking steroids at baseline showed a trend for a shorter survival compared to patients without steroid treatment, despite it not being statistically significant ( p = 0.08); indeed, the hazard ratio for patients receiving regorafenib and steroid was 0.75 versus 0.34 for patients treated with regorafenib alone.

While the global comparison showed a trend toward inferior survival that did not reach statistical significance (log-rank p = 0.080), subgroup-specific analyses revealed significantly worse overall survival for STAS-positive patients after radical anatomical resection ( p = 0.034).

This combined parameter showed a trend of potentially acting as an independent negative prognosticator ( p = 0.08) ( Table S1 ). 3.

However, there was noticeable variability in the degree of plasma concentration changes for our study, indicated by a high standard deviation in the immediate post-exercise plasma OSM concentrations with only marginal significance ( p = 0.080).