Excerpts

Furthermore, with the addition levels of TB in feed, the relative expression of CAT, protein kinase B (Akt), heme oxygenase 1 (HO-1), phosphoinositide 3-kinase (PI3K) and GPx were increased with increasing dietary TB supplementation level up to 0.06% ( P<0.05 ), and thereafter showed a decreasing trend, while, the highest expression levels of copper and zinc superoxide dismutase (Cu/Zn-SOD) was observed in 0.09% TB supplementation in feed ( P<0.05 ) ( Figure 4 ).

The overall effect was borderline significant (p = 0.05).

We selected eight pathways from each database that reflected macrophage function and may be related to OA pathogenesis with the most highly significant p-values (p<0.05) from each database..

Interestingly, the only significant predictor of inflammation as diagnosed by pathology was the tCRM score (OR: 1.90, 95% CI: 1.40–2.68, p < 0.001), while having a male donor to female recipient was protective with borderline significance (OR: 0.27, 95% CI: 0.07–0.98, p = 0.05).

The PMN-MDSC levels correlated negatively at C Malaria with the subsequent lymphocyte circulating values at C Treat2 and reached borderline significance at C Treat3 (Spearman's rank correlation p < 0.05 and p = 0.056, respectively, Figures 5B,C ), but did not correlate with the lymphocyte levels at C Malaria ( p = 0.09, data not shown).

While rhPRG4 treatment showed a trend towards a reduction in PL IL-1β at 24h in Prg4 GT/GT animals, this trend was not statistically significant ( p>0.05 ), due to a high degree of variability in calculated IL-1β concentrations in specimens from the same experimental group.

A correlation of borderline significance was found between FPW and age at biopsy ( r = 0.43; P = 0.05).

p < 0.05 was considered to indicate a significant difference, p < 0.01 an extremely significant difference, and p > 0.05 no significant difference. 3.

The DeLong test confirmed that the combined model’s AUC was significantly higher than that of HDL ( P = 0.006) and showed a trend toward being higher than SIR max ( P = 0.050).

Compared with the FLIPI model for OS prediction, FLIPI-SII showed improved reclassification and discrimination at 3 years (NRI = 0.245, p = 0.034; IDI = 0.013, p = 0.028), and maintained a favorable trend at 5 years (NRI = 0.247, p = 0.050; IDI = 0.018, p = 0.096).

An increasing trend was seen for anti-NP antibodies, Mw-HNM inducing highest anti-NP titers ( p < 0.05).

This finding was consistent in sensitivity analysis (SMD ranged from 0.09 to 0.29), although exclusion of the UC subgroup from the Patel study ( 42 ) resulted in a borderline significant difference favoring higher sVCAM-1 levels in the active disease group (SMD 0.29, 95% CI –0.001 to 0.58, p=0.050).

After 48 hours of gemcitabine treatment, we observed an increasing trend in the protein expression of E-cadherin, whereas the protein expression of Snail was increased and the protein expression of Slug was decreased ( p < 0.05).

Levels of sPD-1, sPD-L1, sLAG-3, sICOS, sGITR and sCD86 were significantly higher in mismatch repair deficient tumors (p<0.05, Mann-Whitney U test) and difference in sGITRL was marginally significant (p=0.050, Mann-Whitney U test).

RT-qPCR analysis revealed that CXCL-8 mRNA expression was significantly downregulated in Ninj1-silenced HUVECs compared to control cells (p=0.016), while TNFAIP3 and CXCL-1 mRNA levels showed a decreasing trend without statistical significance (p>0.05) ( Figures 4A–C ).

In the same way, the intensity of TNFA protein expression was highly significant after PAM2 treatment in comparing to sperm and control (P < 0.05) particular in uterine gland of the endometrium compared to the control ( Figure 5B ).

However, the GG haplotype (rs1800797/rs1818879) was associated with the susceptibility to RA (OR = 1.34, 95% CI, 1.01–1.79, p = 0.03), while the GGG haplotype showed a trend toward RA susceptibility without reaching significance (OR = 1.34, 95% CI, 0.99–1.80, p = 0.05) ( Table 3 ).

The association between TB and rs721917 genotypes was marginally significant ( P = 0.050), and this significance was reduced after adjusting for age and gender (Table 2 ).

However, anti-EA IgM ( Figure 5D ), and anti-EBNA6 IgM ( Figure 5E ) showed a trend to react differently in ME/CFS samples versus BD control samples ( p > 0.05, Fisher exact test) but did not reach statistical significance.

Of these AABs, three of them—ANGPT2, SELE, and CAV2—are detected in ARDS+ patients with a highly significant difference ( Figure 4A and Figure S4 ) (Wilcoxon test p-value <0.05) over ARDS− patients.

This result in PMN-MDSC was in contrast to M-MDSC cell numbers, where mice that were vaped and challenged with LPS had a slightly significant (p<0.05) lower levels of M-MDSC compared to mice that only received the LPS challenge.

An increasing trend of proinflammatory factors was observed in the MOD group ( p < 0.05).

Anti-asexual stage IgG antibody levels post infection were not statistically different between infection routes SPZ Gct and BS Gct (p=0.22), and borderline significant between SPZ Control and BS Control (p=0.050).

The data were considered significant and highly significant for P -values <0.05 and <0.01, respectively.

RA-risk, but were still not significantly changed in the RA/RA-risk comparison, usually showed a change in the same direction, but did not reach statistical significance according to our cut-offs ( p < 0.05, fold change ± 0.5, and expression >50 in all measured samples).