Excerpts

In the same way, the intensity of TNFA protein expression was highly significant after PAM2 treatment in comparing to sperm and control (P < 0.05) particular in uterine gland of the endometrium compared to the control ( Figure 5B ).

However, the GG haplotype (rs1800797/rs1818879) was associated with the susceptibility to RA (OR = 1.34, 95% CI, 1.01–1.79, p = 0.03), while the GGG haplotype showed a trend toward RA susceptibility without reaching significance (OR = 1.34, 95% CI, 0.99–1.80, p = 0.05) ( Table 3 ).

The data were considered significant and highly significant for P -values <0.05 and <0.01, respectively.

Compared to middle-aged ad libitum fed male mice ( Supplementary Figure 2 ), CR3 induced a significant reduction in the frequency of spontaneous Ca 2 + transients ( p < 0.01, Mann-Whitney test) and an almost significant reduction in T-half ( p = 0.05, Mann-Whitney test), thus counteracting all aging-related changes observed in this age group (compare to Figure 3 ).

An increasing trend was seen for anti-NP antibodies, Mw-HNM inducing highest anti-NP titers ( p < 0.05).

The anti-VHSV antibody titer in serum demonstrated an increasing trend from 48 hpiv in the immersion group, which remained significantly ( p < 0.05) higher than that of the NVC control group throughout the immunization period, with further enhancement of the titer at 48 hpc with VHSV.

neonatal T cells CD8 + T cells RNA-sequencing IL-12 T cell activation neonatal immunity Institut National de la Santé et de la Recherche Médicale 10.13039/501100001677 Ligue Contre le Cancer 10.13039/501100004099 Agence Nationale de la Recherche 10.13039/501100001665 Next, we analyzed the patterns of gene expression changes after TCR or TCR-IL12 stimulation, considering only highly significant differential genes (adjusted p < 0.05 and log 2 fold change ≥ 2) after TCR or TCR-IL12 stimulation ( Figure 2A ).

However, our analysis did not reveal a significant trend toward a lower CIR for patients with Tel- or Cen-Bx grafts compared with Cen- or Tel-AA donors (p > 0.05) ( Table 2 ).

Non-hematological disorders showed a trend toward a better OS (77.9 vs. 62.9%; p = 0.05).

Relative Expression of Genes in the Intestine With regard to antioxidant genes, the relative expression of nuclear factor erythroid 2-related factor 2 (Nrf2) showed a trend of increasing first and then decreasing with the addition levels of TB in feed, and the highest levels was observed in 0.06% TB supplementation in feed ( P<0.05 ), however, the relative expression of Kelch-like ECH-associated protein 1 (Keap1) showed an opposite trend with Nrf2.

Our results revealed that three genes ( MTHFD2, PPP1R15A , and WNT5B ) exhibited significant differences in expression ( p < 0.001), whereas SLC2A4 demonstrated a moderately significant difference ( p < 0.05, Figure 7A ).

Compared with the FLIPI model for OS prediction, FLIPI-SII showed improved reclassification and discrimination at 3 years (NRI = 0.245, p = 0.034; IDI = 0.013, p = 0.028), and maintained a favorable trend at 5 years (NRI = 0.247, p = 0.050; IDI = 0.018, p = 0.096).

There was a trend toward significance with the conditioning regimen ( p = 0.05) and intensity of conditioning (myeloablative versus. reduced intensity; p = 0.07).

As shown in Figure 6C , RA-treated DCs showed a trend ( P = 0.05) for increased spreading on E-cadherin.

Additionally, the LF-EA group exhibited an increasing trend in spleen index ( P > 0.05), whereas the HF-EA group showed a significant increase in spleen index compared to the LF-EA group ( P < 0.01).

Compared to the model group, the LF-EA group showed a decreasing trend in uterine mass ( P > 0.05), while the HF-EA group demonstrated reductions in uterine mass ( P < 0.05), both the LF-EA group and the HF-EA group showed a trend towards reduced uterine index, transverse diameter of the uterine horns, kidney index, and ovary index ( P > 0.05).

FEJ treatment showed a trend towards enhancing body weight gain and thymus coefficient and improving the swelling of spleen and liver ( p < 0.05).

However, the association between detectable properdin and graft failure became borderline significant after further adjustment for proteinuria (HR, 1.47; 95% CI 0.85–2.54; P = 0.05).

As shown in Supplementary Figure S4 , we observed an increasing trend in the risk score in patients with pathological stage IV, and it was higher in the M1 stage compared to the M0 stage (p<0.05), suggesting that the risk score effectively reflects the severity of the disease, particularly in relation to features associated with distant metastasis.

After calculating Spearman’s correlation coefficients and correcting for the effect of study center, we identify 30 species and 49 pathways with nominally significant association to the BPDAI score (p < 0.05) ( Figure S3 ).

A correlation of borderline significance was found between FPW and age at biopsy ( r = 0.43; P = 0.05).

Statistical analysis revealed significantly elevated plasma sICOSL levels in patients with early AE compared to those with early VE, demonstrating a highly significant intergroup difference (P<0.05).

Comparison of the mean expression levels between T1D and MA groups revealed highly significant differences for six proteins (sTNFR1, sTNFR2, sIL2Rα, MMP2, sIL6R, and sgp130; P < 1 × 10 −5 ) and moderately significant differences for four proteins (CRP, SAA, sICAM1, and sVCAM1; P < 0.05) (Table S1 in Supplementary Material).

The mucus pH showed a decreasing trend as gestation progressed, and the mucus pH in early pregnancy (5.97 ± 1.07) was significantly higher compared to that during late pregnancy (4.98 ± 1.09; p < 0.05) ( Figure 1 ; Table 2 ).

The p -value was two-tailed and considered statistically significant or highly significant when p <0.05 or p <0.01, respectively.