Excerpts

A platelet count ≥100×10 9 /L, aspartate aminotransferase < 80 U/L, lactate dehydrogenase <500 U/L, and receipt of anti-tumor therapy showed a trend toward better survival but did not reach statistical significance ( P = 0.086, P = 0.075, P = 0.059, and P = 0.080, respectively).

Although adpgk expression showed an increasing trend in trained cells, it was not significantly affected by primary training or secondary stimulation.

However, dnmt1 showed a trend of lower expression in LPS-stimulated groups.

In intestinal supernatants, LCA treatment showed a trend of reduced IL-6 and IL-8 levels after 48 h ( Figures 4E, G ).

Mean fluorescence intensity (MFI) within the segmented E-cadherin network, however, only exhibited a decreasing trend compared to untreated models ( Figure 1H ).

3.75%, P = 0.33), although a numerical trend toward a higher incidence was observed in the dnDSA-positive cohort ( Figure 5C ). 4.

Although the RTX group showed a trend toward a lower 3-year ESRD incidence (42.86% vs. 63.46%), the difference did not reach statistical significance.

Highly significant interactions were also identified for Smoking status (Yes vs No: P-interaction<0.0001), the presence of Brain metastasis (Yes vs No: P-interaction=0.0124), and consistently across TMB subgroups (TMB<10 vs TMB≥10: P-interaction = 0.0330; TMB<20 vs TMB≥20: P-interaction = 0.0192).

Smokers experienced a significant improvement in OS, while non-smokers did not benefit even showed a trend towards deterioration.

on nivolumab combined with sunitinib showed a trend toward superiority over monotherapy in certain subtypes, yet the overall ORR remained far below that observed in common solid tumors ( 10 , 14 ).

Conclusions The relative antiproteinuric effect of telitacicept versus budesonide EC may be modified by baseline proteinuria, with a possible trend toward greater benefit in patients with mild-to-moderate levels.

In non-Asia-enriched trials, the pooled HR was 0.82 (95% CI 0.67-1.00; I2=51%), suggesting a borderline significant survival advantage.

Conversely, a high Treg signature score correlated with a notable trend toward shorter PFS, although no significant difference was observed for OS ( Figures 5E, F ).

Consequently, supplementing randomized controlled trials with large-scale, multi-center studies anchored by objective outcome measures is likely to become an important trend ( 39 ). 4.

However, a minority of studies have reported no significant difference in peripheral blood Treg frequency compared with healthy controls ( 16 ), and some have even suggested an increasing trend, which may be related to heterogeneity in study populations, disease stage, and detection methods ( 17 ).

HFD IRI livers showed a trend toward reduced abundance of phosphatidylcholines, a membrane-stabilizing component, relative to ND IRI, consistent with NAFLD/MAFLD-associated phospholipid dysregulation that sensitizes hepatocytes to metabolic stress ( 27 , 30 , 31 ).

Such findings have suggested that PARP activity above a certain threshold in T lymphocytes has partial significance in the regulation of mucosal immunity in the large intestine.

In the multivariate Cox regression analysis, the five-gene signature (riskScore) showed a trend toward worse prognosis (HR = 1.374, 95% CI: 0.916-2.061), though it did not reach statistical significance (P = 0.125), potentially due to limited sample size ( Supplementary Figure S3B ).

The high-risk group showed a trend toward a higher predicted non-response rate based on the TIDE algorithm, suggesting a potentially poorer response to immunotherapy that warrants further investigation ( Figure 2I ).

The reported immunogenicity data suggest a slight trend toward higher ADA incidence in humanized compared to fully human anti-PD-1 antibodies.

In a clinical trial involving patients with SLE, metformin showed a trend toward reducing disease relapse, however, the difference relative to placebo was not statistically significant ( 73 ).

Only the CD137L–PD-L2 correlation showed borderline significance after FDR correction. 3.6.3.

A P value<0.05 was considered statistically significant, and P < 0.01 was considered highly significant. 3.

For example, although the risk of stroke showed a decreasing trend in recent meta-analyses, the certainty of evidence remains low due to very high heterogeneity and reliance on a mix of observational and randomized evidence.

lactis V9 combined with αPD-1 therapy showed a trend of slowing tumor growth in both tumor models, suggesting that it may enhance the anti-tumor effects of immune checkpoint inhibitors.