Excerpts

The study showed five taxa with a decreasing trend from NAG to IM to GC (two Saccharibacteria , two Porphyromonas, and one Neisseria ).

There was no significant difference in pediatric cell migration after treatment with Stx-1, however a clear trend towards a delay in wound healing was visible.

In our study, full-field VEP measurements showed a trend towards attenuation of the VEP signal upon ocular hypertension, yet did not reach statistical significance, perhaps due to limitations in detection.

Thus, rapamycin-injected mice were smaller and weighed less than DMSO-injected mice—an effect that was highly significant ( Figure 4 D).

CMC2.23 at 20 μM showed a trend for reduced TYR and MITF but the levels did not reach statistical significance ( Figure 3 F).

The IFX t1⁄2 substantially decreased with increased platelet count in HR and RR individuals, so the contribution of platelet-mediated elimination became highly significant at high platelet counts in these individuals.

Besides gyrA and parC , which passed our p -value cut off (5.21 × 10 −7 ), we could find mutations in less-studied genes involved in modifying target enzymes, such as gyrB and parE , as well as in the genes involved in alterations of permeation, such as acrB , ompC , mdtK ( norE ), and mdfA , which did not pass our p -value cutoff but were mildly significant ( p -value around 5 × 10 −3 ).

Then, we applied association analysis between variants and antibiotic resistance phenotypes to reduce high-quality to highly significant variants.

Amongst all studied proteins, only the expression levels of NPM1 and phospho-c-Myc (Ser62) showed a trend towards an increase in both BRAF-mutated cell lines ( Figure 3 ), albeit statistically non-significant when compared to other cell lines.

Three genes ( Bcl2l1 , Ilk , Mfsd2a ) showed statistically significant upregulation in DEX-treated mice ( Figure 3 B–D), while Pdk4 and Kyat3 showed a trend toward upregulation in DEX-treated mice ( Figure 3 E; Supplementary File, Figure S2B ).

However, PTEN-expressing T-ALL cell lines also showed a trend for an inverse relationship between GLI1 protein levels and activated AMPK ( Figure 3 G). 2.4.

Interestingly, we found highly significant negative correlations between initial PD-L1 and all of these chemokines, further corroborating the notion that circulating preoperative PD-L1 might have a prognostic function for resectable BTC ( Supplementary Figure S2A–D ). 2.3.

Notably, in this analysis, patients with increasing PD-L1 concentrations after tumor resection demonstrated a clear trend towards an improved survival compared to patients who displayed further decreasing PD-L1 levels after surgery ( Figure 4 D).

Notably, patients with further decreasing PD-L1 concentrations after surgery showed a trend towards an impaired postoperative outcome.

Patients with low PD-L1 levels displayed a strong trend towards an impaired prognosis, and circulating PD-L1 was negatively correlated with experimental markers of promalignant tumor characteristics such as CCL1, CCL21, CCL25 and CCL26.

Adding cell-free 0.2% HA or 0.2% HAL [ 30 ] did clearly diminish recovery rates, while adding 0.4% or 0.7% M-HAL as luminal filler (current study) showed a trend of increasing TA muscle recovery rates over those achieved with empty nerve guides or CNG filled with cell-free 0.2% HA or 0.2% HAL.

However, the incidence of cancer concerning the group of patients with MI but without HF was present and even showed an increasing trend, but it was not as noticeable as in the group with HF.

At both transfers analysed, and as it happened in L1, substitutions that disappeared at later stages (C2452U, U3402C and U3784C; yellow cells in Table 3 and Table 4 showed a trend to be present in genetic backgrounds containing few mutations from those that fixed at transfer 25 (grey cells in Table 3 and Table 4 ).

In an independent study on melanoma biopsies before treatment, a highly significant correlation of CD4, CD8, CD3, PD-1, and LAG-3 expression in tissue lesions with anti-PD-1 treatment response was observed [ 10 ].

HG + HI), cultivation under dynamic flow conditions in the bioreactor system showed a trend towards thickening of the lamina spongiosa under HG + HI cultivation ( Figure 4 B).

TGFβ expression was significantly higher and SPP1 expression was reduced by a slight trend under dynamic cultivation when comparing basal NG conditions to static cultivation ( Figure 2 B,C). 2.2.

At the same time, decreases in proton leak as energetic change were detected following RT and/or metformin treatment as proton leak is a highly significant aspect of mitochondrial energetics and is implicated in oxygen consumption.

We also observed a decreasing trend in the proportion of very budded high-glucose-treated organoids (those with > 3 buds) with respect to control organoids ( Figure 2 D). 2.3.

Colloid Versus Tubular IPMC All of eight studies investigating colloid type and tubular type IPMC for the main pathological characteristics ( Table 2 ) reported significant or almost significant trend towards less nodal metastasis in colloid carcinomas (16–29% versus 37–63% in tubular type).

Raw concentrations and creatinine adjusted values of the two urinary markers however showed highly significant correlations.