Excerpts

Apart from the loci mentioned above, numerous other loci were identified that may be significant ( p < 0.05, but higher than the significance threshold currently used for GWAS, which is 5 × 10 −8 ).

Bacteroidota and Spirochaetota decreased initially and then increased ( p > 0.05), while Proteobacteria displayed a significant trend of decreasing first and then increasing ( p < 0.05) ( Figure 7 A).

When we assessed glycolytic ECAR flux, non-glycolytic flux (NG-ECAR) was reduced in hypoxia treated astrocytes but just failed to reach significance ( p = 0.0502, unpaired t-test) ( Figure 8 D).

The result of the Chi -square test didn’t support the dependency of Pinb2-7D or Pinb2-7B on kernel hardness, although the association results of Pinb2-7D approached significance ( P = 0.0503).

A strong trend for an increase in this measure was found in non-stressed C57BL/6 mice compared to non-stressed CBA mice ( p = 0.0507).

Tetranor-PGEM levels were also slightly increased (1.18-fold) after 4 weeks of tranilast administration with borderline significance ( p = 0.0507).

Interestingly, expression of TGM2, COL1A1, COL1A22 were not induced in the ex vivo experiments but significantly (in the case of COL1A1 with p = 0.0507 almost significantly) induced in the in vivo situation.

The BV in the MD was marginally insignificant compared to the LD group ( p = 0.051). 2.3.

Males reached borderline significance, with the TC genotype being more highly represented in the CD subtype ( p = 0.051), despite reaching overall model significance ( p = 0.007).

When analyzed independently of the control group, pooled samples from the two groups receiving malonate showed a trend of having higher succinate concentrations than those receiving RIC alone (repeated measures ANOVA, p = 0.051 for interaction), and significantly reduced levels of fumarate (repeated measures ANOVA, p = 0.014 for interaction and p < 0.001 for group allocation) and malate (repeated measures ANOVA, p = 0.019 for group allocation).

The zinc finger transcription factor early growth response 1 (Egr1) was also downregulated in the old HCR and old LCR ( Figure 1 B), but downregulation in old LCR compared to young LCR just missed significance after Bonferroni–Holm correction ( p = 0.051).

Compared to SSc-NCFS patients (0.47), SSc-CFS patients showed a trend of reduced expression of ND4 (0.34, p = 0.051) ( Figure 1 A).

Women in PG had significantly higher triglycerides levels in the second trimester ( p < 0.05), while triglycerides concentrations in the third trimester were also higher in the PG but of borderline significance ( p = 0.051) ( Table 1 ).

Interestingly the co-culture group showed a trend of upregulation of the basal-specific epidermal marker KRT14 with 0.4 folds over the 100% group ( p -value = 0.051; Figure 2 g) while it kept the same upregulation pattern in comparison to the 0% group ( p -value = 0.0005; Figure 2 g).

However, after the inclusion of NT-proBNP (Model B), the association of GDF15 with all-cause mortality was attenuated, reaching borderline significance (HR 2.61; 95% CI: (0.99–6.87), p = 0.051), whereas NT-proBNP retained significance (HR 1.11; 95% CI: (1–1.22), p = 0.044) ( Table S2 ). 2.4.

Most importantly, a significant association of methylated PCDH8 level to tumor maximal diameter at diagnosis (R s = 0.35; p = 0.028) as well as borderline significance to tumor volume (R s = 0.32; p = 0.051) at diagnosis was identified ( Figure 3 A,B).

unfavorable) showed a trend toward the independent association of MALAT1 expression with TTFT in U-CLL (hazard ratio (HR) = 0.581, 95% CI = 0.337−1.002, p = 0.051).

This difference was significantly different in the proliferative phase (post hoc analysis p = 0.045) and borderline significant in the secretory phase ( p = 0.051).

While only a few genes were enriched in ILC1, pericytes and epithelial cells showed only a positive trend towards the induction of CD risk genes in CRC ( p = 0.051 and p = 0.0599, respectively; Figure 5 A).

The inverse non-linear relation of OxPhos plotted as a function of the adrenaline levels narrowly missed statistical significance (r = −0.57, p = 0.051).

We also observed an interaction effect between “comorbid anxiety disorder” and “sex” on 20:4 LPA [F(1,82) = 4.75; p = 0.032], and this was also marginally significant for total LPA [F(1,88) = 3.92; p = 0.051].

Similarly, α-smooth muscle actin (ACTA2) expression displayed a strong trend toward downregulation in the LV ( p = 0.051; Figure 5 E), with numerically lower values also observed in the RV (though not reaching statistical significance).

Immunoglobulin T membrane-bound form ( igt-m ) exhibited the same trend in the 48 h post-feeding sampling time, although not strictly significant ( p = 0.051).

However, after 12 months, the active group showed a trend toward a reduction in TRACP-5b levels compared to the placebo group ( p = 0.051, Figure 2 B).

TMEV-infected Mmp12 −/− mice showed transiently reduced astrogliosis in association with a strong trend ( p = 0.051) for a reduced density of activated/reactive microglia/macrophages compared with wild-type mice at 28 dpi.