Barely Significant

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Evaluating the mean FMD according to disease severity, we found a significant trend towards an endothelial function worsening with COVID-19 severity increase ( Figure 1 , Table 2 ), with a significant difference when comparing the mean FMD of “home care” patients with each category of hospitalized patients, as shown in Table 3 .
In fact, two- and three-year survival rates showed a positive trend in the ipilimumab plus nivolumab -> encorafenib plus binimetinib (arm B: 73% and 62%, respectively) sequence and with the sandwich strategy (arm C: 69% and 60%, respectively) compared with encorafenib plus binimetinib -> ipilimumab plus nivolumab (arm A: 65% and 54%, respectively).
It should be noted that, for the power analysis, the Spearman rank order correlations results using Cramer’s V effect size of independence, in the cases with a moderately significant correlation ( p = >0.01 <0.05), it makes sense to increase sample sizes with a 60% chance of obtaining convincing p -values ( Table 6 ).