Barely Significant

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marginal significancep -value = 0.0541.1× alphagold
In the recessive genetic model, we found a marginal significance only for the association between smoking and IL-27- T4730C (Chi-square test, p -value = 0.054), the frequency of the variant CC genotype being higher in smokers (52.6%) than in non-smokers (30.4 %).
a trend toward significancep = 0.0541.1× alpha
Diastolic blood pressure (DBP) also showed favorable trends, with a significant reduction in the combination therapy group (from 81.6 mmHg to 73.0 mmHg, p = 0.040), a trend toward significance in the SGLT2i group (from 76.0 mmHg to 73.3 mmHg, p = 0.054), and a non-significant reduction in the GLP-1 RA group (from 74.8 mmHg to 70.4 mmHg, p = 0.335).
marginally non-significantp = 0.0541.1× alpha
In the prespecified primary multivariable model, RF positivity was marginally non-significant (aOR 3.44, 95% CI 0.98–12.11, p = 0.054), but became significant in the PFT analysis, but became non-significant after adding dyspnea/Velcro crackles and in the matched analysis, suggesting that any RF signal was not solely explained by symptom-driven ascertainment.