Excerpts

The proportion of PCs showed a trend from increasing to decreasing which peaked on days 14 (Fig. 5b, c ).

The sea-surface salinity reconstructed for the eastern subpolar North Atlantic (MD95-2002 Core) indeed exhibits an increasing trend during the AHP2 termination (Supplementary Figs. 2 , 15e ).

This FcRn-dependent recycling of anti-biotin IgG1-was blocked in a concentration-dependent manner by both MST-HN molecules, whereas the WT-IgG1 or -Fc fragments showed a trend (not significant) towards blockade when used at 500 nM.

We determined that the data met assumptions for sphericity using Mauchly’s test, though this value was close to significance in some cases.

30 days after 131 I, ROS production also showed a decreasing trend in TC patients after stimulation with zymosan (Fig. 4D ).

Furthermore, all groups showed an increase in IL-6 after stimulation, which was highly significant in the MNG group (Fig. 3D , third graph).

The Cauchy combination test is a computationally efficient p -value combination method that provides an accurate p -value approximation for highly significant results (which are of interest) and does not require the correlation structure among the combined p -values to be estimated.

Both blue and green food webs showed a trend of decreasing nestedness with increasing elevation (Fig. 5 ).

Regarding direct effects, elevation positively influenced modularity (standardised coefficient: 0.49) and negatively influenced niche overlap (−0.53) in green food webs, while the opposite (−0.38 and marginally significant 0.10, respectively) was observed in blue ones (Fig. 3c ; Supplementary Table 7 ).

Most significant pairwise differences among vegetation types include comparisons to either barren or boreal peat bog and differences among prostrate-shrub tundra, erect-shrub tundra and wetlands are not or only marginally significant (Table 1 ; Supplementary Table 4 ).

Fourier-transformed EXAFS analyses showed a clear trend that the intensity of Pt-Cl/Pt-S bonds gradually decreased as the annealing temperature rising, accompanied by the increased intensity of Pt-Pt/Pt-Co bonds (Supplementary Fig. 13 ), demonstrating the decomposition of coordination structures and the formation of alloys.

We have previously shown that although only Ag85A-specific IgG on Day 28 were associated with a significantly reduced risk of TB disease, Ag85A-specific IgG on Day −7 also showed a trend towards an association with reduced risk of TB disease that did not reach statistical significance 6 .

The evidence presented in this paper suggests that the outcomes of the listing are consistent with the protection of human health and the environment, as chemical properties associated with both CMR (carcinogenicity, mutagenicity, and reproductive toxicity) and environmental harm are highly significant in explaining the inclusion on the Candidate List.

Mice subsequently treated with Abatacept and IgG-(IL-2) 2 showed a trend towards retention of more functional beta cell mass as judged by glucose tolerance tests (Supplementary Fig. 8 ).

A significant positive correlation of the HAI and the MN titers was found for the H1N1 and H3N2 strains contained in the vaccine formulation, as well as a clear trend for the B strain.

When investigating the GM volume changes across sessions, we observed a symmetrical pattern of highly significant group differences (Fig. 1 , Supplementary Table 1 ), and post hoc analyses revealed that each of these clusters reflected reductions in regional GM in the women who were pregnant between the time points (Supplementary Table 2 ).

A nonsignificant trend was seen toward lower prevalence of diabetes (0.96 [0.90, 1.01]).

In addition, when censoring deaths at 85+ years, the association of i.FCS with CMD-specific mortality became marginally significant (0.92 [0.85, 1.00]).

The presence of these traits suggests an increase in carbohydrate intake within the LN/CA periods, and fits with the data recorded by isotopic analyses, reporting a decreasing trend in animal protein intake and an increase in vegetal protein consumption from EN to LN and CA, along with an intensification of the agricultural practices in South-Italian farming communities at the end of the Neolithic period 25 , 53 .

The only other TTLL enzyme for which we found a clear trend was TTLL13 which is significantly overexpressed in the majority of tumors (Supplementary Fig. 6f ).

By comparing the relative abundance of these cell types across conditions, we found that silencing of circCsnk1g3 was associated with a decreasing trend for regulatory T cells (Treg) and exhausted CD8+ T cells; conversely, cytotoxic CD8+ T cells showed the opposite trend (Fig. 4e ).

As a result of greenhouse warming, the observed OTEC power potential in the EEZ exhibits a positive trend during 1955–2021 with a slope of 0.80 ± 0.09 TW century −1 (Fig. 1e ).

High incidence rates of EV-A71 infection were observed before 5 years of age, which showed an increasing trend before 6 months of age and then declined, but remained very high in children aged 3–5 years old (Fig. 2b ).

In arctic Siberia, time-series δ 13 C values show a decreasing trend from near +6‰ in the Maastakh and basal Khatyspyt formations, and then an oscillation between −5 and +4‰ through the overlying reaches of the interval 25 , 26 , 35 before stabilizing near 0‰ in dolostones of the lower Turkut Formation.

Although activation was highly significant on RGD-12pN surfaces, the density of activated integrin β1 molecules was greater on RGD-23pN and still greater on RGD-33pN surfaces.