Excerpts

In analyses of astroglial/neuronal injury and AD-related blood biomarkers, the Cog-PASC group showed a trend toward higher GFAP levels, although this did not reach statistical significance.

Calculating the relative strength of the TSS hotspot for all disease gene sets listed in the Human Phenotype Ontology 69 , we found highly significant associations ( p adj < 10 −50 ) with over 20 neoplasms and carcinomas (mean Jaccard index JI=0.22), decreased mitochondrial activity (two phenotypes; JI=0.52), seven neurological phenotypes (JI=0.18) and defective limb development (three phenotypes; JI=0.11), Fig. 5 c.

5B ), demonstrating a highly significant and time-dependent reduction in the punctate morphology of sec24D but not sec24A.

Although variability among samples limited definitive conclusions, each mouse showed a trend towards higher levels of laminin-α2 in the injured TA compared to the uninjured TA at 4 DPI, but not at 10 DPI (Fig.

7d ), and the correlation of Log 2 -Fold-Changes of nominally significant genes was low between different brain regions, and modest between 4 and 12 weeks for the same brain region (Supplementary Fig. 7e ).

Consequently, the NRE dom /PRE dom mainly features a decreasing trend in the exposed areas with global silicate rocks.

Consistently, we observed significant translational and post-translational attenuation of eQTL effect across all PhastCons score strata on top of a clear trend of decreased QTL effect size as the evolution conservation scores increase (Fig.

To further reduce the number of false positives, for each potential omics-specific QTL identified at 10% FDR we further test genotype association with the other two omics-types and remove any variant that has nominally significant association.

The FD is of resource economics traits and dominant vegetation type (herbaceous and woody wetlands) had a marginally significant interaction effect on productivity (Supplementary Table 4 and Supplementary Fig. 3a ).

3 ) shows an increasing trend in Δ F net from values below zero after March 2015 to positive values in 2019.

Analysis of cell populations show an increasing trend in the proportion of fibroblast after Mtb infection (Supplementary Fig. 2F ).

A positive trend in tumour-localized CAR T cell mass was observed for mice bearing cytokine-expressing tumours compared with those with unmodified tumours (+37% in SK-N-AS and +18% in SK-N-BE2c), although this did not reach statistical significance.

However, with the widest prior ranges (60 and 80), the relative risk estimates associated with NA and HA stalk were less precise, with credible intervals overlapping 1, suggesting borderline significance.

When the mean incubation period increased from 1 to 2 days, some borderline significant parameters—such as the effect of HA stalk on susceptibility and NA on infectivity—shifted slightly above 1 in the upper value of the 95% credible intervals.

In line with knock-down by siRNA, treatment with the calcium channel blocker drug nicardipine 55 or AOX1 inhibitor drug raloxifene 56 also showed a trend towards increased HDR when combined with M3814 (Fig. 3h ).

Podocalyxin, a negatively charged sialylated glycoprotein involved in polarization 17 and basal organization 18 , exhibited stable protein expression and an increasing trend in the HF group (Fig. 3c, d , Supplementary Fig. 3a ).

Lastly, we emphasize that not all lectins followed the simple rule of preferring higher surface-availability, as lectins such as PHA-L actually showed a trend of preferring their binding motif to be somewhat buried (Supplementary Fig. 10e and f ), potentially indicating additional interactions with distal sequence contexts.

5g ), resulting in a nonsignificant trend towards greater nearest neighbor distances in synapses with ongoing fusion.

However, transcriptomic investigations have consistently identified approximately the same number of genes being up- or down-regulated during seedling or cotyledon de-etiolation, and none have demonstrated a clear trend in gene upregulation 8 – 11 .

While TMX NPs showed a trend of improvement over the free drug (Supplementary Fig. 13B ), the p -value did not reach statistical significance.

1 A shows that the total adoption rate in Washington is around 1.9% in 2022, and the incremental adoption rate presents an increasing trend from 2010 to 2022.

Other inflammatory genes such as Tnf, Il6, Il10, Cxcl2 and Ifnb also showed a trend towards higher expression levels in the lungs of RPC mice at this time point.

We found that the PNS group showed a trend toward lower incidence rates of HAEC and total complications across all subgroups.

Sedimentary archives from the ECS reveal a striking divergence: while δ 13 C org exhibits an increasing trend, 10 of 13 cores show coherent declines in δ 15 N from the early 1900s to present, with an average rate of −1.09 ± 0.48‰ per century (Supplementary Figs. 8 and 9a–b ).

Conversely, a weak trend between MW and toxicity suggests that heavier compounds are less toxic.