Excerpts

S 1b ), we have mainly considered the conclusion obtained with RT-COV (marginally significant), because both the RT variability and mean RT decreased in this case (see Methods, Data analyses).

In the SP, related to the large interannual variability, none of the three components shows a significant trend, yielding no significant trend in the energy.

Or both annual maximum discharge series derived from the GCM and PRISM have a significant trend, but of opposite sign.

In addition, the mitochondrial compartment length showed a decreasing trend when comparing the 5- and 60-min postphotoactivation periods in VAP KD but not in SNCA and SRGAP2 KD (Supplementary Fig. 4a, b ).

This information may be highly significant for the future design of more effective tumor-targeting NPs.

The bottom line of all these numerical findings is that the same system exhibits a quite significant response to the periodic driving away from thermal equilibrium, but hardly shows any reaction to the same driving as the unperturbed system approaches thermal equilibrium, or if it already started out near thermal equilibrium (stalled response).

The TC intensification rate (IR) also shows an increasing trend; and this trend increases with the quantile of IR (Supplementary Fig. 1c ), contributing to the overall increase in TC intensity.

Furthermore, Cox proportional hazards model analysis 38 indicated that five of the transcriptomic markers ( STMN1, WDR12, AZIN1, MAD2L1 , and MCM4 ) had a significant association with response to Enzalutamide (Wald p value < 0.05, Supplementary Data 5C , see Methods), yet many of them were borderline significant and did not outperform MYC and NME2 (Supplementary Data 7C ).

These had little effects on the relationships found: Chl a emerged consistently as highly significant and the NBSS-temperature relationship remained non-significant.

As expected, the resulting reconstructions showed a clear trend of decreasing resolution as the tilt angle is increased (Fig. 1a ); at 0° stage tilt, the resolution is 2.3 Å, but the resolution drops to 2.8 Å at 30° stage tilt, and 4.0 Å at 60° stage tilt.

We observed a weak trend whereby longer transcripts are better enriched (Fig. 4b and Supplementary Fig. 4c ).

2d ) showed a trend, whereby the intensity increased for the peak at ~1.0 V, while the peak at ~1.4 V lost intensity.

Of importance, there was a strong trend supporting a reverse correlation between DLDA score and CD8 lymphocytic infiltration in posttreatment samples suggesting that viral replication plays an important role in the observed posttreatment remodeling of tumor microenvironment.

5e ) showed a decreasing trend from layer 4 to layer 2/3, and the reduced biases were significant between layer 4 (granular, G) and 2/3 (supragranular, SG) (Fig. 5d , G vs.

Along the ventral pathway from V1 to V4, red bias against green peaked in V1 and then declined, whereas blue bias against yellow showed an increasing trend.

The latter results indicate that while the ecological advantage of genomovars DW07 and CZ05 at high-salt conditions may be significant, it is apparently not strong enough to purge diversity within the species (i.e., completely outcompete remaining genomovars), and genomovars that may be less-adapted to high-salt concentrations (e.g., CZ34 and CM11) appear to survive such (unfavorable) conditions, presumably as (viable) members of the rare biosphere.

As the float moved to the edge of CE 1, the temperature displayed an increasing trend, while nitrate, Chl and POC showed a decreasing trend (Fig.

Ten loci showed nominally significant effects in the HUNT study in accordance with the expected statistical power (Supplementary Data 9 ).

Aβ-induced APEL was characterized through a transwell assay, where a range of concentrations (0 μM–40 μM) were employed, before two concentrations, 20 μM and 40 μM, were selected for further experiments due to their highly significant induction of leakiness (Supplementary Fig. 3 ).

We thus performed downstream analyses on the combined tinnitus GWAS meta-analysis, which had a highly significant h 2 SNP = 0.07 (SE = 0.004, on the liability scale).

TgLC mice with TAM injection fed with fenofibrate diet showed a trend of improved food intake compared with TgLC mice with TAM injection fed with regular chow (Fig.

All five test sets yielded one-sided paired Wilcoxon signed-rank test p values < 2.2E10-16, indicating that the reduction of F-ranks by applying the (M + A) α model in comparison to the ALC baseline model was highly significant (Supplementary Table 1 , Fig. 1A, B ).

The marginally non-significant negative correlation with extinction rates in Coleoptera with the rise of angiosperms during the ATR seems to support this idea.

However, there were two events, one involving aneuploidies and the other involving a homoeologous exchange that, while statistically highly significant and physically very large, could only be explained either by assuming that the individual sequenced underwent a somatic mutation that led to somatic mosaicism for the chromosomal aberration or that the sequenced material derived from at least two genetically heterogeneous individuals differing for the detected aberration.

In this study, using mosquitoes harboring the entire range of salivary gland sporozoite loads observed in the field, we demonstrate a strong and highly significant correlation between mosquito parasite burden and inoculum size.