Excerpts

2d ), miR-204 and miR-148a were confirmed by quantitative PCR (qPCR), with a strong trend for miR-9 ( Supplementary Fig. 2e ).

Immunofluorescence staining indicated that mediastinal FALCs of naive Il1rl1 −/− mice are smaller than their BALB/c counterparts, flow cytometric analysis of digested pericardial FALCs showed a trend for fewer cells in the mediastinal adipose but this did not reach significance ( Fig. 3b ).

Thus, our 3C–PCR studies showed a nonsignificant trend towards increased interaction frequencies for Gad1-Myo3a/Gad2 and a significant decrease in Gad1 -TSS (−55kb) Loop in PFC of ‘TIME B' mice previously exposed to MK-801 ( Fig. 4c ).

A highly significant correlation (Pearson's correlation coefficient >0.84) between these two parameters was observed ( Fig. 9d,e ).

Although in this simulation a fully equilibrated final state is not achieved within the very long simulation time span, due to the slowness of folding kinetics, we find clear evidence of a partially folded state, with only about 20% of fully unfolded duplexes remaining and with nematic order parameter S ≈0.5, which shows a clear trend towards greater values as the system evolves toward full equilibration.

Cox regression analysis of WHO grade IV (GBM) patients divided into BRCA1 low (<14.5%) and BRCA1 high (>14.5%) or RRM2 negative and positive groups showed a trend toward worse survival of BRCA1 high and RRM2 positive patients (251 days for BRCA1 low versus 159 days for BRCA1 high and 320 days for RRM2 negat. versus 148 for RRM2 posit.; Fig. 6d,g , respectively).

And there is a clear trend that both E g and A 1g peak frequencies move to the higher wavenumber region, when the thickness of sheets decreases.

Nevertheless, the circulating insulin levels in diabetic IL-1r −/− were significantly decreased compared with non-diabetic counterparts, while a strong trend towards decreased levels was found in diabetic Tlr2 −/− and Casp1 −/− mice, even though it was not statically different.

The four cases, labelled F 10.7 =200, 170, 120 and 80, indicate a clear trend of the Ly α radiances varying with solar activity.

Energy gaps of Mg 3 Sb 2− x Bi x show a decreasing trend from 0.43 to 0.08 eV as x increases from 0.5 to 1.5 ( Fig. 3b ), suggesting that the bipolar effect will be obvious when x >1.

This suggests that the fairly significant temperature difference between these sites ultimately does not influence their metabolic responses to elevated P CO2 , adding weight to the idea that the use of 15 °C did not cause bias by stressing the northernmost population.

Further below, at depth >300 m, the transition scale reverses to a decreasing trend with depth and this decrease in L t appears to be largely due to the weakening in internal wave KE level with depth ( Fig. 6h ).

A trend of less body weight loss was noted in KO chimeric mice, although no statistical difference was apparent between the KO and WT groups ( Fig. 7c ).

Promoter enrichment was borderline significant, but not to the degree of recurrent or highly recurrent gained VELs.

In particular, we used a three-site class model, because we found a highly significant difference when compared with a discrete two-site class model, indicating heterogeneous levels of purifying selection within the protein domains.

We chose K =5 for our analyses because its cross-validation errors: (1) are relative low, (2) do not overlap much with the range of the previous K and (3) have highly significant difference compared with the previous K but not so much with the next K value ( Supplementary Fig. 9a ).

For species for which information is available, the number of levels across species indeed follows an increasing trend as a function of the effective population size, ranging from n =5 in humans with relatively small effective population size of ∼10 4 and correspondingly less efficient selection, n =8 in macaque with intermediate effective population size of the order of 10 5 , and n =10 in mice with the largest effective population size of ∼5 × 10 5 (refs 48 , 49 ).

We note that this implementation allows mood both to change gradually due to the aggregated effect of multiple outcomes as is considered typical for mood, or more rapidly, in response to a single highly significant outcome (as is more characteristic of emotions 31 ).

Likewise cells expressing IGF1R/IR showed a strong trend toward increase in IGF-1-induced glycolysis rate (1.6-fold) and maximal glycolytic capacity (1.5-fold) compared to cells expressing IGF1R ( Fig. 1f,g ).

From each region we chose two or more SNPs for replication: the most significant SNP plus one or more additional SNPs and, where available, highly significant exonic variants.

The acute hazard quotient has remained relatively steady in spring wheat, although a decreasing trend is apparent since 1998 ( Fig. 4 ).

The CMIP5 multi-model ensemble mean forced response in HT BSO does show a positive trend (∼8 TW per 37 years, Fig. 4 ).

9e ) mRNA levels of collagen I and III showed a strong trend towards increased expression ( Supplementary Fig. 9f–g ).

11 , reveals an increasing trend, indicating that bias-modulated performance of the device was not responsible for the obtained signals.

WT CHCHD10 transfected cells showed a nonsignificant trend toward increased mitochondrial length compared to vector control transfected cells both at basal and carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone (FCCP) conditions ( Fig. 3i–k ).